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Clinical Characteristics of Anti-TIF-1γ Antibody-Positive Dermatomyositis Associated with Malignancy

We retrospectively analyzed the clinical and laboratory data of patients diagnosed with anti-transcriptional intermediary factor 1 (TIF-1γ) antibody-positive polymyositis (PM)/dermatomyositis (DM) to clarify the characteristics of this disease. We identified 14 patients with TIF-1γ antibody-positive...

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Autores principales: Harada, Yumi, Tominaga, Masaki, Iitoh, Eriko, Kaieda, Shinjiro, Koga, Takuma, Fujimoto, Kiminori, Chikasue, Tomonori, Obara, Hitoshi, Kakuma, Tatsuyuki, Ida, Hiroaki, Kawayama, Tomotaka, Hoshino, Tomoaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8999723/
https://www.ncbi.nlm.nih.gov/pubmed/35407533
http://dx.doi.org/10.3390/jcm11071925
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author Harada, Yumi
Tominaga, Masaki
Iitoh, Eriko
Kaieda, Shinjiro
Koga, Takuma
Fujimoto, Kiminori
Chikasue, Tomonori
Obara, Hitoshi
Kakuma, Tatsuyuki
Ida, Hiroaki
Kawayama, Tomotaka
Hoshino, Tomoaki
author_facet Harada, Yumi
Tominaga, Masaki
Iitoh, Eriko
Kaieda, Shinjiro
Koga, Takuma
Fujimoto, Kiminori
Chikasue, Tomonori
Obara, Hitoshi
Kakuma, Tatsuyuki
Ida, Hiroaki
Kawayama, Tomotaka
Hoshino, Tomoaki
author_sort Harada, Yumi
collection PubMed
description We retrospectively analyzed the clinical and laboratory data of patients diagnosed with anti-transcriptional intermediary factor 1 (TIF-1γ) antibody-positive polymyositis (PM)/dermatomyositis (DM) to clarify the characteristics of this disease. We identified 14 patients with TIF-1γ antibody-positive DM (TIF-1γ DM), 47 with anti-aminoacyl-tRNA synthetase antibody (ARS)-positive PM/DM, and 24 with anti-melanoma differentiation-associated gene 5 antibody (MDA-5)-positive PM/DM treated at the Kurume University Hospital between 2002 and 2020. Patients with TIF-1γ DM were significantly older than the other two groups. Nine patients with TIF-1γ DM were female, thirteen patients had DM, and one had clinically amyopathic DM. Primary malignant lesions were lung (3), uterus (2), colon (2), breast (2), ovary (1), lymphoma (1), and unknown (2). Cutaneous manifestation and dysphagia were the most common symptoms in TIF-1γ DM. Erythema (9/14), the V-neck sign (8/14), heliotrope (9/14), and nailfold telangiectasia (14/14) were significantly more common in TIF-1γ DM. Furthermore, no patients with TIF-1γ DM had interstitial lung abnormality on high-resolution CT. In patients with TIF-1γ DM, the frequency of dysphagia and unusual erythema, particularly that which spreads from the trunk, and nailfold telangiectasia, were characteristic findings. In most patients with TIF-1γ DM, it is necessary to administer other immunosuppressive drugs along with glucocorticoids.
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spelling pubmed-89997232022-04-12 Clinical Characteristics of Anti-TIF-1γ Antibody-Positive Dermatomyositis Associated with Malignancy Harada, Yumi Tominaga, Masaki Iitoh, Eriko Kaieda, Shinjiro Koga, Takuma Fujimoto, Kiminori Chikasue, Tomonori Obara, Hitoshi Kakuma, Tatsuyuki Ida, Hiroaki Kawayama, Tomotaka Hoshino, Tomoaki J Clin Med Article We retrospectively analyzed the clinical and laboratory data of patients diagnosed with anti-transcriptional intermediary factor 1 (TIF-1γ) antibody-positive polymyositis (PM)/dermatomyositis (DM) to clarify the characteristics of this disease. We identified 14 patients with TIF-1γ antibody-positive DM (TIF-1γ DM), 47 with anti-aminoacyl-tRNA synthetase antibody (ARS)-positive PM/DM, and 24 with anti-melanoma differentiation-associated gene 5 antibody (MDA-5)-positive PM/DM treated at the Kurume University Hospital between 2002 and 2020. Patients with TIF-1γ DM were significantly older than the other two groups. Nine patients with TIF-1γ DM were female, thirteen patients had DM, and one had clinically amyopathic DM. Primary malignant lesions were lung (3), uterus (2), colon (2), breast (2), ovary (1), lymphoma (1), and unknown (2). Cutaneous manifestation and dysphagia were the most common symptoms in TIF-1γ DM. Erythema (9/14), the V-neck sign (8/14), heliotrope (9/14), and nailfold telangiectasia (14/14) were significantly more common in TIF-1γ DM. Furthermore, no patients with TIF-1γ DM had interstitial lung abnormality on high-resolution CT. In patients with TIF-1γ DM, the frequency of dysphagia and unusual erythema, particularly that which spreads from the trunk, and nailfold telangiectasia, were characteristic findings. In most patients with TIF-1γ DM, it is necessary to administer other immunosuppressive drugs along with glucocorticoids. MDPI 2022-03-30 /pmc/articles/PMC8999723/ /pubmed/35407533 http://dx.doi.org/10.3390/jcm11071925 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Harada, Yumi
Tominaga, Masaki
Iitoh, Eriko
Kaieda, Shinjiro
Koga, Takuma
Fujimoto, Kiminori
Chikasue, Tomonori
Obara, Hitoshi
Kakuma, Tatsuyuki
Ida, Hiroaki
Kawayama, Tomotaka
Hoshino, Tomoaki
Clinical Characteristics of Anti-TIF-1γ Antibody-Positive Dermatomyositis Associated with Malignancy
title Clinical Characteristics of Anti-TIF-1γ Antibody-Positive Dermatomyositis Associated with Malignancy
title_full Clinical Characteristics of Anti-TIF-1γ Antibody-Positive Dermatomyositis Associated with Malignancy
title_fullStr Clinical Characteristics of Anti-TIF-1γ Antibody-Positive Dermatomyositis Associated with Malignancy
title_full_unstemmed Clinical Characteristics of Anti-TIF-1γ Antibody-Positive Dermatomyositis Associated with Malignancy
title_short Clinical Characteristics of Anti-TIF-1γ Antibody-Positive Dermatomyositis Associated with Malignancy
title_sort clinical characteristics of anti-tif-1γ antibody-positive dermatomyositis associated with malignancy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8999723/
https://www.ncbi.nlm.nih.gov/pubmed/35407533
http://dx.doi.org/10.3390/jcm11071925
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