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Maternal, Perinatal and Neonatal Outcomes of Triplet Pregnancies According to Chorionicity: A Systematic Review of the Literature and Meta-Analysis

Triplet pregnancies are rare events that affect approximately 93 in 100,000 deliveries in the world, especially due to the increased use of assisted reproductive techniques and older maternal age. Triplet pregnancies are associated with a higher risk of fetal and maternal morbidity and mortality com...

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Autores principales: Bernal Claverol, Mireia, Ruiz Minaya, María, Aracil Moreno, Irene, Tizón, Santiago García, Pintado Recarte, Pilar, Alvarez-Mon, Melchor, Arribas, Coral Bravo, Ortega, Miguel A., De Leon-Luis, Juan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8999732/
https://www.ncbi.nlm.nih.gov/pubmed/35407479
http://dx.doi.org/10.3390/jcm11071871
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author Bernal Claverol, Mireia
Ruiz Minaya, María
Aracil Moreno, Irene
Tizón, Santiago García
Pintado Recarte, Pilar
Alvarez-Mon, Melchor
Arribas, Coral Bravo
Ortega, Miguel A.
De Leon-Luis, Juan A.
author_facet Bernal Claverol, Mireia
Ruiz Minaya, María
Aracil Moreno, Irene
Tizón, Santiago García
Pintado Recarte, Pilar
Alvarez-Mon, Melchor
Arribas, Coral Bravo
Ortega, Miguel A.
De Leon-Luis, Juan A.
author_sort Bernal Claverol, Mireia
collection PubMed
description Triplet pregnancies are rare events that affect approximately 93 in 100,000 deliveries in the world, especially due to the increased use of assisted reproductive techniques and older maternal age. Triplet pregnancies are associated with a higher risk of fetal and maternal morbidity and mortality compared to twins and singletons. Chorionicity has been proposed as a major determinant of perinatal and maternal outcomes in triplet pregnancies, although further evidence is needed to clarify the extent and real influence of this factor. Thus, the aim of this study was to conduct a systematic review of the literature and a meta-analysis of the maternal and perinatal outcomes of triplet pregnancies, evaluating how chorionicity may influence these results. A total of 46 studies with 43,653 triplet pregnancies and 128,145 live births were included. Among the main results of our study, we found a broad spectrum of fetal and maternal complications, especially in the group of monochorionic and dichorionic pregnancies. Risk of admission to NICU, respiratory distress, sepsis, necrotizing enterocolitis, perinatal and intrauterine mortality were all found to be higher in non-TCTA pregnancies than in TCTA pregnancies. To date, our meta-analysis includes the largest population sample and number of studies conducted in this field, evaluating a wide variety of outcome measures. The heterogeneity and retrospective design of the studies included in our research represent the main limitations of this review. More evidence is needed to fully assess outcome measures that could not be studied in this review due to scarcity of publications or insufficient sample size.
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spelling pubmed-89997322022-04-12 Maternal, Perinatal and Neonatal Outcomes of Triplet Pregnancies According to Chorionicity: A Systematic Review of the Literature and Meta-Analysis Bernal Claverol, Mireia Ruiz Minaya, María Aracil Moreno, Irene Tizón, Santiago García Pintado Recarte, Pilar Alvarez-Mon, Melchor Arribas, Coral Bravo Ortega, Miguel A. De Leon-Luis, Juan A. J Clin Med Article Triplet pregnancies are rare events that affect approximately 93 in 100,000 deliveries in the world, especially due to the increased use of assisted reproductive techniques and older maternal age. Triplet pregnancies are associated with a higher risk of fetal and maternal morbidity and mortality compared to twins and singletons. Chorionicity has been proposed as a major determinant of perinatal and maternal outcomes in triplet pregnancies, although further evidence is needed to clarify the extent and real influence of this factor. Thus, the aim of this study was to conduct a systematic review of the literature and a meta-analysis of the maternal and perinatal outcomes of triplet pregnancies, evaluating how chorionicity may influence these results. A total of 46 studies with 43,653 triplet pregnancies and 128,145 live births were included. Among the main results of our study, we found a broad spectrum of fetal and maternal complications, especially in the group of monochorionic and dichorionic pregnancies. Risk of admission to NICU, respiratory distress, sepsis, necrotizing enterocolitis, perinatal and intrauterine mortality were all found to be higher in non-TCTA pregnancies than in TCTA pregnancies. To date, our meta-analysis includes the largest population sample and number of studies conducted in this field, evaluating a wide variety of outcome measures. The heterogeneity and retrospective design of the studies included in our research represent the main limitations of this review. More evidence is needed to fully assess outcome measures that could not be studied in this review due to scarcity of publications or insufficient sample size. MDPI 2022-03-28 /pmc/articles/PMC8999732/ /pubmed/35407479 http://dx.doi.org/10.3390/jcm11071871 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bernal Claverol, Mireia
Ruiz Minaya, María
Aracil Moreno, Irene
Tizón, Santiago García
Pintado Recarte, Pilar
Alvarez-Mon, Melchor
Arribas, Coral Bravo
Ortega, Miguel A.
De Leon-Luis, Juan A.
Maternal, Perinatal and Neonatal Outcomes of Triplet Pregnancies According to Chorionicity: A Systematic Review of the Literature and Meta-Analysis
title Maternal, Perinatal and Neonatal Outcomes of Triplet Pregnancies According to Chorionicity: A Systematic Review of the Literature and Meta-Analysis
title_full Maternal, Perinatal and Neonatal Outcomes of Triplet Pregnancies According to Chorionicity: A Systematic Review of the Literature and Meta-Analysis
title_fullStr Maternal, Perinatal and Neonatal Outcomes of Triplet Pregnancies According to Chorionicity: A Systematic Review of the Literature and Meta-Analysis
title_full_unstemmed Maternal, Perinatal and Neonatal Outcomes of Triplet Pregnancies According to Chorionicity: A Systematic Review of the Literature and Meta-Analysis
title_short Maternal, Perinatal and Neonatal Outcomes of Triplet Pregnancies According to Chorionicity: A Systematic Review of the Literature and Meta-Analysis
title_sort maternal, perinatal and neonatal outcomes of triplet pregnancies according to chorionicity: a systematic review of the literature and meta-analysis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8999732/
https://www.ncbi.nlm.nih.gov/pubmed/35407479
http://dx.doi.org/10.3390/jcm11071871
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