Cargando…

Characteristic Immune Dynamics in COVID-19 Patients with Cardiac Dysfunction

Background: We aimed to explore immune parameters in COVID-19 patients admitted to the intensive care unit (ICU) to identify distinctive features in patients with cardiac injury. Methods: A total of 30 COVID-19 patients >18 years admitted to the ICU were studied on days D1, D3 and D7 after admiss...

Descripción completa

Detalles Bibliográficos
Autores principales: Gonzalez, Filipe André, Ângelo-Dias, Miguel, Martins, Catarina, Gomes, Rui, Bacariza, Jacobo, Fernandes, Antero, Borrego, Luís Miguel, Group, EchoCrit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8999785/
https://www.ncbi.nlm.nih.gov/pubmed/35407485
http://dx.doi.org/10.3390/jcm11071880
_version_ 1784685273476497408
author Gonzalez, Filipe André
Ângelo-Dias, Miguel
Martins, Catarina
Gomes, Rui
Bacariza, Jacobo
Fernandes, Antero
Borrego, Luís Miguel
Group, EchoCrit
author_facet Gonzalez, Filipe André
Ângelo-Dias, Miguel
Martins, Catarina
Gomes, Rui
Bacariza, Jacobo
Fernandes, Antero
Borrego, Luís Miguel
Group, EchoCrit
author_sort Gonzalez, Filipe André
collection PubMed
description Background: We aimed to explore immune parameters in COVID-19 patients admitted to the intensive care unit (ICU) to identify distinctive features in patients with cardiac injury. Methods: A total of 30 COVID-19 patients >18 years admitted to the ICU were studied on days D1, D3 and D7 after admission. Cardiac function was assessed using speckle-tracking echocardiography (STE). Peripheral blood immunophenotyping, cardiac (pro-BNP; troponin) and inflammatory biomarkers were simultaneously evaluated. Results: Cardiac dysfunction (DYS) was detected by STE in 73% of patients: 40% left ventricle (LV) systolic dysfunction, 60% LV diastolic dysfunction, 37% right ventricle systolic dysfunction. High-sensitivity cardiac troponin (hs-cTn) was detectable in 43.3% of the patients with a median value of 13.00 ng/L. There were no significant differences between DYS and nDYS patients regarding mortality, organ dysfunction, cardiac (including hs-cTn) or inflammatory biomarkers. Patients with DYS showed persistently lower lymphocyte counts (median 896 [661–1837] cells/µL vs. 2141 [924–3306] cells/µL, p = 0.058), activated CD3 (median 85 [66–170] cells/µL vs. 186 [142–259] cells/µL, p = 0.047) and CD4 T cells (median 33 [28–40] cells/µL vs. 63 [48–79] cells/µL, p = 0.005), and higher effector memory T cells (TEM) at baseline (CD4%: 10.9 [6.4–19.2] vs. 5.9 [4.2–12.8], p = 0.025; CD8%: 15.7 [7.9–22.8] vs. 8.1 [7.7–13.7], p = 0.035; CD8 counts: 40 cells/µL [17–61] vs. 10 cells/µL [7–17], p = 0.011) than patients without cardiac dysfunction. Conclusion: Our study suggests an association between the immunological trait and cardiac dysfunction in severe COVID-19 patients.
format Online
Article
Text
id pubmed-8999785
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-89997852022-04-12 Characteristic Immune Dynamics in COVID-19 Patients with Cardiac Dysfunction Gonzalez, Filipe André Ângelo-Dias, Miguel Martins, Catarina Gomes, Rui Bacariza, Jacobo Fernandes, Antero Borrego, Luís Miguel Group, EchoCrit J Clin Med Article Background: We aimed to explore immune parameters in COVID-19 patients admitted to the intensive care unit (ICU) to identify distinctive features in patients with cardiac injury. Methods: A total of 30 COVID-19 patients >18 years admitted to the ICU were studied on days D1, D3 and D7 after admission. Cardiac function was assessed using speckle-tracking echocardiography (STE). Peripheral blood immunophenotyping, cardiac (pro-BNP; troponin) and inflammatory biomarkers were simultaneously evaluated. Results: Cardiac dysfunction (DYS) was detected by STE in 73% of patients: 40% left ventricle (LV) systolic dysfunction, 60% LV diastolic dysfunction, 37% right ventricle systolic dysfunction. High-sensitivity cardiac troponin (hs-cTn) was detectable in 43.3% of the patients with a median value of 13.00 ng/L. There were no significant differences between DYS and nDYS patients regarding mortality, organ dysfunction, cardiac (including hs-cTn) or inflammatory biomarkers. Patients with DYS showed persistently lower lymphocyte counts (median 896 [661–1837] cells/µL vs. 2141 [924–3306] cells/µL, p = 0.058), activated CD3 (median 85 [66–170] cells/µL vs. 186 [142–259] cells/µL, p = 0.047) and CD4 T cells (median 33 [28–40] cells/µL vs. 63 [48–79] cells/µL, p = 0.005), and higher effector memory T cells (TEM) at baseline (CD4%: 10.9 [6.4–19.2] vs. 5.9 [4.2–12.8], p = 0.025; CD8%: 15.7 [7.9–22.8] vs. 8.1 [7.7–13.7], p = 0.035; CD8 counts: 40 cells/µL [17–61] vs. 10 cells/µL [7–17], p = 0.011) than patients without cardiac dysfunction. Conclusion: Our study suggests an association between the immunological trait and cardiac dysfunction in severe COVID-19 patients. MDPI 2022-03-28 /pmc/articles/PMC8999785/ /pubmed/35407485 http://dx.doi.org/10.3390/jcm11071880 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gonzalez, Filipe André
Ângelo-Dias, Miguel
Martins, Catarina
Gomes, Rui
Bacariza, Jacobo
Fernandes, Antero
Borrego, Luís Miguel
Group, EchoCrit
Characteristic Immune Dynamics in COVID-19 Patients with Cardiac Dysfunction
title Characteristic Immune Dynamics in COVID-19 Patients with Cardiac Dysfunction
title_full Characteristic Immune Dynamics in COVID-19 Patients with Cardiac Dysfunction
title_fullStr Characteristic Immune Dynamics in COVID-19 Patients with Cardiac Dysfunction
title_full_unstemmed Characteristic Immune Dynamics in COVID-19 Patients with Cardiac Dysfunction
title_short Characteristic Immune Dynamics in COVID-19 Patients with Cardiac Dysfunction
title_sort characteristic immune dynamics in covid-19 patients with cardiac dysfunction
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8999785/
https://www.ncbi.nlm.nih.gov/pubmed/35407485
http://dx.doi.org/10.3390/jcm11071880
work_keys_str_mv AT gonzalezfilipeandre characteristicimmunedynamicsincovid19patientswithcardiacdysfunction
AT angelodiasmiguel characteristicimmunedynamicsincovid19patientswithcardiacdysfunction
AT martinscatarina characteristicimmunedynamicsincovid19patientswithcardiacdysfunction
AT gomesrui characteristicimmunedynamicsincovid19patientswithcardiacdysfunction
AT bacarizajacobo characteristicimmunedynamicsincovid19patientswithcardiacdysfunction
AT fernandesantero characteristicimmunedynamicsincovid19patientswithcardiacdysfunction
AT borregoluismiguel characteristicimmunedynamicsincovid19patientswithcardiacdysfunction
AT groupechocrit characteristicimmunedynamicsincovid19patientswithcardiacdysfunction