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Macular Blood Flow and Pattern Electroretinogram in Normal Tension Glaucoma

Purpose: To investigate whether macular vessel density (VD) was associated with the pattern electroretinogram (PERG) in normal tension glaucoma (NTG). Design: Cross-sectional study. Methods: Seventy-six eyes from patients with NTG were included in this study. Macular VD was calculated from the super...

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Autores principales: Jeon, Soo Ji, Jung, Kyoung In, Park, Chan Kee, Park, Hae-Young Lopilly
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8999873/
https://www.ncbi.nlm.nih.gov/pubmed/35407398
http://dx.doi.org/10.3390/jcm11071790
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author Jeon, Soo Ji
Jung, Kyoung In
Park, Chan Kee
Park, Hae-Young Lopilly
author_facet Jeon, Soo Ji
Jung, Kyoung In
Park, Chan Kee
Park, Hae-Young Lopilly
author_sort Jeon, Soo Ji
collection PubMed
description Purpose: To investigate whether macular vessel density (VD) was associated with the pattern electroretinogram (PERG) in normal tension glaucoma (NTG). Design: Cross-sectional study. Methods: Seventy-six eyes from patients with NTG were included in this study. Macular VD was calculated from the superficial retinal layer, including the retinal nerve fiber layer (RNFL) and ganglion cell layer (GCL), using the built-in software provided with the optical coherence tomography angiography (OCTA) device. Functional parameters were obtained from standard automated perimetry (SAP) and PERG, using a commercial ERG stimulator. Moreover, structural parameters, such as peripapillary RNFL and macular ganglion cell/inner plexiform layer (GCIPL) thickness, were measured using OCT. Results: Patients with higher VD had higher N95 amplitude (p = 0.048). Macular VD was significantly correlated with N95 amplitude, irrespective of disease severity (r = 0.352, p = 0.002 for the total subjects and r = 0.276, p = 0.043 for mild glaucoma). According to regression analyses, N95 amplitude and macular VD were bidirectional significant factors (p = 0.035 and 0.019, respectively). For patients with mild to moderate glaucoma, N95 amplitude and macular VD were also significantly associated bidirectionally, according to regression analyses (p = 0.032 and 0.040, respectively). Conclusions: Macular VD was significantly associated with N95 amplitude from PERG. The correlation was prominent in early glaucoma, in contrast to the other structural or functional parameters. When considering that PERG represents the objective function of the retinal ganglion cell (RGC), macular VD was associated with RGC dysfunction before the functional change became apparent on SAP.
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spelling pubmed-89998732022-04-12 Macular Blood Flow and Pattern Electroretinogram in Normal Tension Glaucoma Jeon, Soo Ji Jung, Kyoung In Park, Chan Kee Park, Hae-Young Lopilly J Clin Med Article Purpose: To investigate whether macular vessel density (VD) was associated with the pattern electroretinogram (PERG) in normal tension glaucoma (NTG). Design: Cross-sectional study. Methods: Seventy-six eyes from patients with NTG were included in this study. Macular VD was calculated from the superficial retinal layer, including the retinal nerve fiber layer (RNFL) and ganglion cell layer (GCL), using the built-in software provided with the optical coherence tomography angiography (OCTA) device. Functional parameters were obtained from standard automated perimetry (SAP) and PERG, using a commercial ERG stimulator. Moreover, structural parameters, such as peripapillary RNFL and macular ganglion cell/inner plexiform layer (GCIPL) thickness, were measured using OCT. Results: Patients with higher VD had higher N95 amplitude (p = 0.048). Macular VD was significantly correlated with N95 amplitude, irrespective of disease severity (r = 0.352, p = 0.002 for the total subjects and r = 0.276, p = 0.043 for mild glaucoma). According to regression analyses, N95 amplitude and macular VD were bidirectional significant factors (p = 0.035 and 0.019, respectively). For patients with mild to moderate glaucoma, N95 amplitude and macular VD were also significantly associated bidirectionally, according to regression analyses (p = 0.032 and 0.040, respectively). Conclusions: Macular VD was significantly associated with N95 amplitude from PERG. The correlation was prominent in early glaucoma, in contrast to the other structural or functional parameters. When considering that PERG represents the objective function of the retinal ganglion cell (RGC), macular VD was associated with RGC dysfunction before the functional change became apparent on SAP. MDPI 2022-03-24 /pmc/articles/PMC8999873/ /pubmed/35407398 http://dx.doi.org/10.3390/jcm11071790 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Jeon, Soo Ji
Jung, Kyoung In
Park, Chan Kee
Park, Hae-Young Lopilly
Macular Blood Flow and Pattern Electroretinogram in Normal Tension Glaucoma
title Macular Blood Flow and Pattern Electroretinogram in Normal Tension Glaucoma
title_full Macular Blood Flow and Pattern Electroretinogram in Normal Tension Glaucoma
title_fullStr Macular Blood Flow and Pattern Electroretinogram in Normal Tension Glaucoma
title_full_unstemmed Macular Blood Flow and Pattern Electroretinogram in Normal Tension Glaucoma
title_short Macular Blood Flow and Pattern Electroretinogram in Normal Tension Glaucoma
title_sort macular blood flow and pattern electroretinogram in normal tension glaucoma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8999873/
https://www.ncbi.nlm.nih.gov/pubmed/35407398
http://dx.doi.org/10.3390/jcm11071790
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