In Silico Drug Repositioning to Target the SARS-CoV-2 Main Protease as Covalent Inhibitors Employing a Combined Structure-Based Virtual Screening Strategy of Pharmacophore Models and Covalent Docking

The epidemic caused by the SARS-CoV-2 coronavirus, which has spread rapidly throughout the world, requires urgent and effective treatments considering that the appearance of viral variants limits the efficacy of vaccines. The main protease of SARS-CoV-2 (M(pro)) is a highly conserved cysteine protei...

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Detalles Bibliográficos
Autores principales: Vázquez-Mendoza, Luis Heriberto, Mendoza-Figueroa, Humberto L., García-Vázquez, Juan Benjamín, Correa-Basurto, José, García-Machorro, Jazmín
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8999907/
https://www.ncbi.nlm.nih.gov/pubmed/35409348
http://dx.doi.org/10.3390/ijms23073987

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