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Bacterial Cellulose and ECM Hydrogels: An Innovative Approach for Cardiovascular Regenerative Medicine

Cardiovascular diseases are considered the leading cause of death in the world, accounting for approximately 85% of sudden death cases. In dogs and cats, sudden cardiac death occurs commonly, despite the scarcity of available pathophysiological and prevalence data. Conventional treatments are not ab...

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Autores principales: da Silva, Izabela Gabriela Rodrigues, Pantoja, Bruna Tássia dos Santos, Almeida, Gustavo Henrique Doná Rodrigues, Carreira, Ana Claudia Oliveira, Miglino, Maria Angélica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8999934/
https://www.ncbi.nlm.nih.gov/pubmed/35409314
http://dx.doi.org/10.3390/ijms23073955
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author da Silva, Izabela Gabriela Rodrigues
Pantoja, Bruna Tássia dos Santos
Almeida, Gustavo Henrique Doná Rodrigues
Carreira, Ana Claudia Oliveira
Miglino, Maria Angélica
author_facet da Silva, Izabela Gabriela Rodrigues
Pantoja, Bruna Tássia dos Santos
Almeida, Gustavo Henrique Doná Rodrigues
Carreira, Ana Claudia Oliveira
Miglino, Maria Angélica
author_sort da Silva, Izabela Gabriela Rodrigues
collection PubMed
description Cardiovascular diseases are considered the leading cause of death in the world, accounting for approximately 85% of sudden death cases. In dogs and cats, sudden cardiac death occurs commonly, despite the scarcity of available pathophysiological and prevalence data. Conventional treatments are not able to treat injured myocardium. Despite advances in cardiac therapy in recent decades, transplantation remains the gold standard treatment for most heart diseases in humans. In veterinary medicine, therapy seeks to control clinical signs, delay the evolution of the disease and provide a better quality of life, although transplantation is the ideal treatment. Both human and veterinary medicine face major challenges regarding the transplantation process, although each area presents different realities. In this context, it is necessary to search for alternative methods that overcome the recovery deficiency of injured myocardial tissue. Application of biomaterials is one of the most innovative treatments for heart regeneration, involving the use of hydrogels from decellularized extracellular matrix, and their association with nanomaterials, such as alginate, chitosan, hyaluronic acid and gelatin. A promising material is bacterial cellulose hydrogel, due to its nanostructure and morphology being similar to collagen. Cellulose provides support and immobilization of cells, which can result in better cell adhesion, growth and proliferation, making it a safe and innovative material for cardiovascular repair.
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spelling pubmed-89999342022-04-12 Bacterial Cellulose and ECM Hydrogels: An Innovative Approach for Cardiovascular Regenerative Medicine da Silva, Izabela Gabriela Rodrigues Pantoja, Bruna Tássia dos Santos Almeida, Gustavo Henrique Doná Rodrigues Carreira, Ana Claudia Oliveira Miglino, Maria Angélica Int J Mol Sci Review Cardiovascular diseases are considered the leading cause of death in the world, accounting for approximately 85% of sudden death cases. In dogs and cats, sudden cardiac death occurs commonly, despite the scarcity of available pathophysiological and prevalence data. Conventional treatments are not able to treat injured myocardium. Despite advances in cardiac therapy in recent decades, transplantation remains the gold standard treatment for most heart diseases in humans. In veterinary medicine, therapy seeks to control clinical signs, delay the evolution of the disease and provide a better quality of life, although transplantation is the ideal treatment. Both human and veterinary medicine face major challenges regarding the transplantation process, although each area presents different realities. In this context, it is necessary to search for alternative methods that overcome the recovery deficiency of injured myocardial tissue. Application of biomaterials is one of the most innovative treatments for heart regeneration, involving the use of hydrogels from decellularized extracellular matrix, and their association with nanomaterials, such as alginate, chitosan, hyaluronic acid and gelatin. A promising material is bacterial cellulose hydrogel, due to its nanostructure and morphology being similar to collagen. Cellulose provides support and immobilization of cells, which can result in better cell adhesion, growth and proliferation, making it a safe and innovative material for cardiovascular repair. MDPI 2022-04-02 /pmc/articles/PMC8999934/ /pubmed/35409314 http://dx.doi.org/10.3390/ijms23073955 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
da Silva, Izabela Gabriela Rodrigues
Pantoja, Bruna Tássia dos Santos
Almeida, Gustavo Henrique Doná Rodrigues
Carreira, Ana Claudia Oliveira
Miglino, Maria Angélica
Bacterial Cellulose and ECM Hydrogels: An Innovative Approach for Cardiovascular Regenerative Medicine
title Bacterial Cellulose and ECM Hydrogels: An Innovative Approach for Cardiovascular Regenerative Medicine
title_full Bacterial Cellulose and ECM Hydrogels: An Innovative Approach for Cardiovascular Regenerative Medicine
title_fullStr Bacterial Cellulose and ECM Hydrogels: An Innovative Approach for Cardiovascular Regenerative Medicine
title_full_unstemmed Bacterial Cellulose and ECM Hydrogels: An Innovative Approach for Cardiovascular Regenerative Medicine
title_short Bacterial Cellulose and ECM Hydrogels: An Innovative Approach for Cardiovascular Regenerative Medicine
title_sort bacterial cellulose and ecm hydrogels: an innovative approach for cardiovascular regenerative medicine
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8999934/
https://www.ncbi.nlm.nih.gov/pubmed/35409314
http://dx.doi.org/10.3390/ijms23073955
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