Cargando…

Impaired Endothelial Function in Convalescent Phase of COVID-19: A 3 Month Follow Up Observational Prospective Study

Background: Endothelial dysfunction has a role in acute COVID-19, contributing to systemic inflammatory syndrome, acute respiratory distress syndrome, and vascular events. Evidence regarding COVID-19 middle- and long-term consequences on endothelium are still lacking. Our study aimed to evaluate if...

Descripción completa

Detalles Bibliográficos
Autores principales: Santoro, Luca, Falsetti, Lorenzo, Zaccone, Vincenzo, Nesci, Antonio, Tosato, Matteo, Giupponi, Bianca, Savastano, Maria Cristina, Moroncini, Gianluca, Gasbarrini, Antonio, Landi, Francesco, Santoliquido, Angelo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8999944/
https://www.ncbi.nlm.nih.gov/pubmed/35407382
http://dx.doi.org/10.3390/jcm11071774
_version_ 1784685312220332032
author Santoro, Luca
Falsetti, Lorenzo
Zaccone, Vincenzo
Nesci, Antonio
Tosato, Matteo
Giupponi, Bianca
Savastano, Maria Cristina
Moroncini, Gianluca
Gasbarrini, Antonio
Landi, Francesco
Santoliquido, Angelo
author_facet Santoro, Luca
Falsetti, Lorenzo
Zaccone, Vincenzo
Nesci, Antonio
Tosato, Matteo
Giupponi, Bianca
Savastano, Maria Cristina
Moroncini, Gianluca
Gasbarrini, Antonio
Landi, Francesco
Santoliquido, Angelo
author_sort Santoro, Luca
collection PubMed
description Background: Endothelial dysfunction has a role in acute COVID-19, contributing to systemic inflammatory syndrome, acute respiratory distress syndrome, and vascular events. Evidence regarding COVID-19 middle- and long-term consequences on endothelium are still lacking. Our study aimed to evaluate if COVID-19 severity could significantly affect the endothelial function after three months from the acute phase. Methods: We assessed endothelial function in outpatients with previous COVID-19 three months after negative SARS-CoV-2 molecular test by measuring flow-mediated dilation (FMD) in patients categorized according to a four-variable COVID-19 severity scale (“home care”; “hospital, no oxygen”; “hospital, oxygen”; “hospital requiring high-flow nasal canula, non-invasive ventilation, invasive mechanical ventilation, or extracorporeal membrane oxygenation”). FMD difference among COVID-19 severity categories was assessed with analysis of variance; we further clarified the relationship between FMD and previous COVID-19 severity with multivariate logistic models. Results: Among 658 consecutive COVID-19 subjects, we observed a significant linear trend of FMD reduction with the increase of the COVID-19 category (p < 0.0001). The presence of endothelial dysfunction was more frequent among hospitalized patients (78.3%) with respect to home-care patients (21.7%; p < 0.0001). COVID-19 severity was associated with increased endothelial dysfunction risk (OR: 1.354; 95% CI: 1.06–1.71; p = 0.011) at multivariate binary logistic analysis. FMD showed a significant direct correlation with PaO2 (p = 0.004), P/F ratio (p = 0.004), FEV1 (p = 0.008), and 6MWT (p = 0.0001). Conclusions: Hospitalized COVID-19 subjects showed an impaired endothelial function three months after the acute phase that correlated with pulmonary function impairment. Further studies are needed to evaluate if these subjects are at higher risk of developing pulmonary disease or future cardiovascular events.
format Online
Article
Text
id pubmed-8999944
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-89999442022-04-12 Impaired Endothelial Function in Convalescent Phase of COVID-19: A 3 Month Follow Up Observational Prospective Study Santoro, Luca Falsetti, Lorenzo Zaccone, Vincenzo Nesci, Antonio Tosato, Matteo Giupponi, Bianca Savastano, Maria Cristina Moroncini, Gianluca Gasbarrini, Antonio Landi, Francesco Santoliquido, Angelo J Clin Med Article Background: Endothelial dysfunction has a role in acute COVID-19, contributing to systemic inflammatory syndrome, acute respiratory distress syndrome, and vascular events. Evidence regarding COVID-19 middle- and long-term consequences on endothelium are still lacking. Our study aimed to evaluate if COVID-19 severity could significantly affect the endothelial function after three months from the acute phase. Methods: We assessed endothelial function in outpatients with previous COVID-19 three months after negative SARS-CoV-2 molecular test by measuring flow-mediated dilation (FMD) in patients categorized according to a four-variable COVID-19 severity scale (“home care”; “hospital, no oxygen”; “hospital, oxygen”; “hospital requiring high-flow nasal canula, non-invasive ventilation, invasive mechanical ventilation, or extracorporeal membrane oxygenation”). FMD difference among COVID-19 severity categories was assessed with analysis of variance; we further clarified the relationship between FMD and previous COVID-19 severity with multivariate logistic models. Results: Among 658 consecutive COVID-19 subjects, we observed a significant linear trend of FMD reduction with the increase of the COVID-19 category (p < 0.0001). The presence of endothelial dysfunction was more frequent among hospitalized patients (78.3%) with respect to home-care patients (21.7%; p < 0.0001). COVID-19 severity was associated with increased endothelial dysfunction risk (OR: 1.354; 95% CI: 1.06–1.71; p = 0.011) at multivariate binary logistic analysis. FMD showed a significant direct correlation with PaO2 (p = 0.004), P/F ratio (p = 0.004), FEV1 (p = 0.008), and 6MWT (p = 0.0001). Conclusions: Hospitalized COVID-19 subjects showed an impaired endothelial function three months after the acute phase that correlated with pulmonary function impairment. Further studies are needed to evaluate if these subjects are at higher risk of developing pulmonary disease or future cardiovascular events. MDPI 2022-03-23 /pmc/articles/PMC8999944/ /pubmed/35407382 http://dx.doi.org/10.3390/jcm11071774 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Santoro, Luca
Falsetti, Lorenzo
Zaccone, Vincenzo
Nesci, Antonio
Tosato, Matteo
Giupponi, Bianca
Savastano, Maria Cristina
Moroncini, Gianluca
Gasbarrini, Antonio
Landi, Francesco
Santoliquido, Angelo
Impaired Endothelial Function in Convalescent Phase of COVID-19: A 3 Month Follow Up Observational Prospective Study
title Impaired Endothelial Function in Convalescent Phase of COVID-19: A 3 Month Follow Up Observational Prospective Study
title_full Impaired Endothelial Function in Convalescent Phase of COVID-19: A 3 Month Follow Up Observational Prospective Study
title_fullStr Impaired Endothelial Function in Convalescent Phase of COVID-19: A 3 Month Follow Up Observational Prospective Study
title_full_unstemmed Impaired Endothelial Function in Convalescent Phase of COVID-19: A 3 Month Follow Up Observational Prospective Study
title_short Impaired Endothelial Function in Convalescent Phase of COVID-19: A 3 Month Follow Up Observational Prospective Study
title_sort impaired endothelial function in convalescent phase of covid-19: a 3 month follow up observational prospective study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8999944/
https://www.ncbi.nlm.nih.gov/pubmed/35407382
http://dx.doi.org/10.3390/jcm11071774
work_keys_str_mv AT santoroluca impairedendothelialfunctioninconvalescentphaseofcovid19a3monthfollowupobservationalprospectivestudy
AT falsettilorenzo impairedendothelialfunctioninconvalescentphaseofcovid19a3monthfollowupobservationalprospectivestudy
AT zacconevincenzo impairedendothelialfunctioninconvalescentphaseofcovid19a3monthfollowupobservationalprospectivestudy
AT nesciantonio impairedendothelialfunctioninconvalescentphaseofcovid19a3monthfollowupobservationalprospectivestudy
AT tosatomatteo impairedendothelialfunctioninconvalescentphaseofcovid19a3monthfollowupobservationalprospectivestudy
AT giupponibianca impairedendothelialfunctioninconvalescentphaseofcovid19a3monthfollowupobservationalprospectivestudy
AT savastanomariacristina impairedendothelialfunctioninconvalescentphaseofcovid19a3monthfollowupobservationalprospectivestudy
AT moroncinigianluca impairedendothelialfunctioninconvalescentphaseofcovid19a3monthfollowupobservationalprospectivestudy
AT gasbarriniantonio impairedendothelialfunctioninconvalescentphaseofcovid19a3monthfollowupobservationalprospectivestudy
AT landifrancesco impairedendothelialfunctioninconvalescentphaseofcovid19a3monthfollowupobservationalprospectivestudy
AT santoliquidoangelo impairedendothelialfunctioninconvalescentphaseofcovid19a3monthfollowupobservationalprospectivestudy
AT impairedendothelialfunctioninconvalescentphaseofcovid19a3monthfollowupobservationalprospectivestudy