Do Circulating Histones Represent the Missing Link among COVID-19 Infection and Multiorgan Injuries, Microvascular Coagulopathy and Systemic Hyperinflammation?

Several studies shed light on the interplay among inflammation, thrombosis, multi-organ failures and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Increasing levels of both free and/or circulating histones have been associated to coronavirus disease 2019 (COVID-19), enhanci...

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Autores principales: Ligi, Daniela, Maniscalco, Rosanna, Plebani, Mario, Lippi, Giuseppe, Mannello, Ferdinando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Opinion
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8999947/
https://www.ncbi.nlm.nih.gov/pubmed/35407410
http://dx.doi.org/10.3390/jcm11071800
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author Ligi, Daniela
Maniscalco, Rosanna
Plebani, Mario
Lippi, Giuseppe
Mannello, Ferdinando
author_facet Ligi, Daniela
Maniscalco, Rosanna
Plebani, Mario
Lippi, Giuseppe
Mannello, Ferdinando
author_sort Ligi, Daniela
collection PubMed
description Several studies shed light on the interplay among inflammation, thrombosis, multi-organ failures and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Increasing levels of both free and/or circulating histones have been associated to coronavirus disease 2019 (COVID-19), enhancing the risk of heart attack and stroke with coagulopathy and systemic hyperinflammation. In this view, by considering both the biological and clinical rationale, circulating histones may be relevant as diagnostic biomarkers for stratifying COVID-19 patients at higher risk for viral sepsis, and as predictive laboratory medicine tool for targeted therapies.
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spelling pubmed-89999472022-04-12 Do Circulating Histones Represent the Missing Link among COVID-19 Infection and Multiorgan Injuries, Microvascular Coagulopathy and Systemic Hyperinflammation? Ligi, Daniela Maniscalco, Rosanna Plebani, Mario Lippi, Giuseppe Mannello, Ferdinando J Clin Med Opinion Several studies shed light on the interplay among inflammation, thrombosis, multi-organ failures and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Increasing levels of both free and/or circulating histones have been associated to coronavirus disease 2019 (COVID-19), enhancing the risk of heart attack and stroke with coagulopathy and systemic hyperinflammation. In this view, by considering both the biological and clinical rationale, circulating histones may be relevant as diagnostic biomarkers for stratifying COVID-19 patients at higher risk for viral sepsis, and as predictive laboratory medicine tool for targeted therapies. MDPI 2022-03-24 /pmc/articles/PMC8999947/ /pubmed/35407410 http://dx.doi.org/10.3390/jcm11071800 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Opinion
Ligi, Daniela
Maniscalco, Rosanna
Plebani, Mario
Lippi, Giuseppe
Mannello, Ferdinando
Do Circulating Histones Represent the Missing Link among COVID-19 Infection and Multiorgan Injuries, Microvascular Coagulopathy and Systemic Hyperinflammation?
title Do Circulating Histones Represent the Missing Link among COVID-19 Infection and Multiorgan Injuries, Microvascular Coagulopathy and Systemic Hyperinflammation?
title_full Do Circulating Histones Represent the Missing Link among COVID-19 Infection and Multiorgan Injuries, Microvascular Coagulopathy and Systemic Hyperinflammation?
title_fullStr Do Circulating Histones Represent the Missing Link among COVID-19 Infection and Multiorgan Injuries, Microvascular Coagulopathy and Systemic Hyperinflammation?
title_full_unstemmed Do Circulating Histones Represent the Missing Link among COVID-19 Infection and Multiorgan Injuries, Microvascular Coagulopathy and Systemic Hyperinflammation?
title_short Do Circulating Histones Represent the Missing Link among COVID-19 Infection and Multiorgan Injuries, Microvascular Coagulopathy and Systemic Hyperinflammation?
title_sort do circulating histones represent the missing link among covid-19 infection and multiorgan injuries, microvascular coagulopathy and systemic hyperinflammation?
topic Opinion
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8999947/
https://www.ncbi.nlm.nih.gov/pubmed/35407410
http://dx.doi.org/10.3390/jcm11071800
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