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Role of Obesity, Physical Exercise, Adipose Tissue-Skeletal Muscle Crosstalk and Molecular Advances in Barrett’s Esophagus and Esophageal Adenocarcinoma

Both obesity and esophageal adenocarcinoma (EAC) rates have increased sharply in the United States and Western Europe in recent years. EAC is a classic example of obesity-related cancer where the risk of EAC increases with increasing body mass index. Pathologically altered visceral fat in obesity ap...

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Autores principales: Bilski, Jan, Pinkas, Monika, Wojcik-Grzybek, Dagmara, Magierowski, Marcin, Korbut, Edyta, Mazur-Bialy, Agnieszka, Krzysiek-Maczka, Gracjana, Kwiecien, Slawomir, Magierowska, Katarzyna, Brzozowski, Tomasz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8999972/
https://www.ncbi.nlm.nih.gov/pubmed/35409299
http://dx.doi.org/10.3390/ijms23073942
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author Bilski, Jan
Pinkas, Monika
Wojcik-Grzybek, Dagmara
Magierowski, Marcin
Korbut, Edyta
Mazur-Bialy, Agnieszka
Krzysiek-Maczka, Gracjana
Kwiecien, Slawomir
Magierowska, Katarzyna
Brzozowski, Tomasz
author_facet Bilski, Jan
Pinkas, Monika
Wojcik-Grzybek, Dagmara
Magierowski, Marcin
Korbut, Edyta
Mazur-Bialy, Agnieszka
Krzysiek-Maczka, Gracjana
Kwiecien, Slawomir
Magierowska, Katarzyna
Brzozowski, Tomasz
author_sort Bilski, Jan
collection PubMed
description Both obesity and esophageal adenocarcinoma (EAC) rates have increased sharply in the United States and Western Europe in recent years. EAC is a classic example of obesity-related cancer where the risk of EAC increases with increasing body mass index. Pathologically altered visceral fat in obesity appears to play a key role in this process. Visceral obesity may promote EAC by directly affecting gastroesophageal reflux disease and Barrett’s esophagus (BE), as well as a less reflux-dependent effect, including the release of pro-inflammatory adipokines and insulin resistance. Deregulation of adipokine production, such as the shift to an increased amount of leptin relative to “protective” adiponectin, has been implicated in the pathogenesis of BE and EAC. This review discusses not only the epidemiology and pathophysiology of obesity in BE and EAC, but also molecular alterations at the level of mRNA and proteins associated with these esophageal pathologies and the potential role of adipokines and myokines in these disorders. Particular attention is given to discussing the possible crosstalk of adipokines and myokines during exercise. It is concluded that lifestyle interventions to increase regular physical activity could be helpful as a promising strategy for preventing the development of BE and EAC.
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spelling pubmed-89999722022-04-12 Role of Obesity, Physical Exercise, Adipose Tissue-Skeletal Muscle Crosstalk and Molecular Advances in Barrett’s Esophagus and Esophageal Adenocarcinoma Bilski, Jan Pinkas, Monika Wojcik-Grzybek, Dagmara Magierowski, Marcin Korbut, Edyta Mazur-Bialy, Agnieszka Krzysiek-Maczka, Gracjana Kwiecien, Slawomir Magierowska, Katarzyna Brzozowski, Tomasz Int J Mol Sci Review Both obesity and esophageal adenocarcinoma (EAC) rates have increased sharply in the United States and Western Europe in recent years. EAC is a classic example of obesity-related cancer where the risk of EAC increases with increasing body mass index. Pathologically altered visceral fat in obesity appears to play a key role in this process. Visceral obesity may promote EAC by directly affecting gastroesophageal reflux disease and Barrett’s esophagus (BE), as well as a less reflux-dependent effect, including the release of pro-inflammatory adipokines and insulin resistance. Deregulation of adipokine production, such as the shift to an increased amount of leptin relative to “protective” adiponectin, has been implicated in the pathogenesis of BE and EAC. This review discusses not only the epidemiology and pathophysiology of obesity in BE and EAC, but also molecular alterations at the level of mRNA and proteins associated with these esophageal pathologies and the potential role of adipokines and myokines in these disorders. Particular attention is given to discussing the possible crosstalk of adipokines and myokines during exercise. It is concluded that lifestyle interventions to increase regular physical activity could be helpful as a promising strategy for preventing the development of BE and EAC. MDPI 2022-04-01 /pmc/articles/PMC8999972/ /pubmed/35409299 http://dx.doi.org/10.3390/ijms23073942 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Bilski, Jan
Pinkas, Monika
Wojcik-Grzybek, Dagmara
Magierowski, Marcin
Korbut, Edyta
Mazur-Bialy, Agnieszka
Krzysiek-Maczka, Gracjana
Kwiecien, Slawomir
Magierowska, Katarzyna
Brzozowski, Tomasz
Role of Obesity, Physical Exercise, Adipose Tissue-Skeletal Muscle Crosstalk and Molecular Advances in Barrett’s Esophagus and Esophageal Adenocarcinoma
title Role of Obesity, Physical Exercise, Adipose Tissue-Skeletal Muscle Crosstalk and Molecular Advances in Barrett’s Esophagus and Esophageal Adenocarcinoma
title_full Role of Obesity, Physical Exercise, Adipose Tissue-Skeletal Muscle Crosstalk and Molecular Advances in Barrett’s Esophagus and Esophageal Adenocarcinoma
title_fullStr Role of Obesity, Physical Exercise, Adipose Tissue-Skeletal Muscle Crosstalk and Molecular Advances in Barrett’s Esophagus and Esophageal Adenocarcinoma
title_full_unstemmed Role of Obesity, Physical Exercise, Adipose Tissue-Skeletal Muscle Crosstalk and Molecular Advances in Barrett’s Esophagus and Esophageal Adenocarcinoma
title_short Role of Obesity, Physical Exercise, Adipose Tissue-Skeletal Muscle Crosstalk and Molecular Advances in Barrett’s Esophagus and Esophageal Adenocarcinoma
title_sort role of obesity, physical exercise, adipose tissue-skeletal muscle crosstalk and molecular advances in barrett’s esophagus and esophageal adenocarcinoma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8999972/
https://www.ncbi.nlm.nih.gov/pubmed/35409299
http://dx.doi.org/10.3390/ijms23073942
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