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BRCA2 C-Terminal RAD51-Binding Domain Confers Resistance to DNA-Damaging Agents

Breast cancer type 2 susceptibility (BRCA2) protein is crucial for initiating DNA damage repair after chemotherapy with DNA interstrand crosslinking agents or X-ray irradiation, which induces DNA double-strand breaks. BRCA2 contains a C-terminal RAD51-binding domain (CTRBD) that interacts with RAD51...

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Detalles Bibliográficos
Autores principales:	Zhu, Zida, Kitano, Taisuke, Morimatsu, Masami, Tanaka, Arisa, Morioka, Ryo, Lin, Xianghui, Orino, Koichi, Yoshikawa, Yasunaga
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9000072/ https://www.ncbi.nlm.nih.gov/pubmed/35409418 http://dx.doi.org/10.3390/ijms23074060

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