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Pulsatile contractions and pattern formation in excitable actomyosin cortex
The actin cortex is an active adaptive material, embedded with complex regulatory networks that can sense, generate, and transmit mechanical forces. The cortex exhibits a wide range of dynamic behaviours, from generating pulsatory contractions and travelling waves to forming organised structures. De...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9000090/ https://www.ncbi.nlm.nih.gov/pubmed/35353813 http://dx.doi.org/10.1371/journal.pcbi.1009981 |
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author | Staddon, Michael F. Munro, Edwin M. Banerjee, Shiladitya |
author_facet | Staddon, Michael F. Munro, Edwin M. Banerjee, Shiladitya |
author_sort | Staddon, Michael F. |
collection | PubMed |
description | The actin cortex is an active adaptive material, embedded with complex regulatory networks that can sense, generate, and transmit mechanical forces. The cortex exhibits a wide range of dynamic behaviours, from generating pulsatory contractions and travelling waves to forming organised structures. Despite the progress in characterising the biochemical and mechanical components of the actin cortex, the emergent dynamics of this mechanochemical system is poorly understood. Here we develop a reaction-diffusion model for the RhoA signalling network, the upstream regulator for actomyosin assembly and contractility, coupled to an active actomyosin gel, to investigate how the interplay between chemical signalling and mechanical forces regulates stresses and patterns in the cortex. We demonstrate that mechanochemical feedback in the cortex acts to destabilise homogeneous states and robustly generate pulsatile contractions. By tuning active stress in the system, we show that the cortex can generate propagating contraction pulses, form network structures, or exhibit topological turbulence. |
format | Online Article Text |
id | pubmed-9000090 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-90000902022-04-12 Pulsatile contractions and pattern formation in excitable actomyosin cortex Staddon, Michael F. Munro, Edwin M. Banerjee, Shiladitya PLoS Comput Biol Research Article The actin cortex is an active adaptive material, embedded with complex regulatory networks that can sense, generate, and transmit mechanical forces. The cortex exhibits a wide range of dynamic behaviours, from generating pulsatory contractions and travelling waves to forming organised structures. Despite the progress in characterising the biochemical and mechanical components of the actin cortex, the emergent dynamics of this mechanochemical system is poorly understood. Here we develop a reaction-diffusion model for the RhoA signalling network, the upstream regulator for actomyosin assembly and contractility, coupled to an active actomyosin gel, to investigate how the interplay between chemical signalling and mechanical forces regulates stresses and patterns in the cortex. We demonstrate that mechanochemical feedback in the cortex acts to destabilise homogeneous states and robustly generate pulsatile contractions. By tuning active stress in the system, we show that the cortex can generate propagating contraction pulses, form network structures, or exhibit topological turbulence. Public Library of Science 2022-03-30 /pmc/articles/PMC9000090/ /pubmed/35353813 http://dx.doi.org/10.1371/journal.pcbi.1009981 Text en © 2022 Staddon et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Staddon, Michael F. Munro, Edwin M. Banerjee, Shiladitya Pulsatile contractions and pattern formation in excitable actomyosin cortex |
title | Pulsatile contractions and pattern formation in excitable actomyosin cortex |
title_full | Pulsatile contractions and pattern formation in excitable actomyosin cortex |
title_fullStr | Pulsatile contractions and pattern formation in excitable actomyosin cortex |
title_full_unstemmed | Pulsatile contractions and pattern formation in excitable actomyosin cortex |
title_short | Pulsatile contractions and pattern formation in excitable actomyosin cortex |
title_sort | pulsatile contractions and pattern formation in excitable actomyosin cortex |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9000090/ https://www.ncbi.nlm.nih.gov/pubmed/35353813 http://dx.doi.org/10.1371/journal.pcbi.1009981 |
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