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Factors Influencing Immune Restoration in People Living with HIV/AIDS

Introduction: Immune restoration is a key clinical aspect that is pursued in the care of human immunodeficiency virus (HIV)-infected patients. Despite effective antiretroviral treatment and undetectable viremia, immune recovery is often incomplete. Materials and methods: Data from 311 Caucasian pati...

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Autores principales: Aksak-Wąs, Bogusz Jan, Urbańska, Anna, Scheibe, Kaja, Serwin, Karol, Leszczyszyn-Pynka, Magdalena, Rafalska-Kosior, Milena, Gołąb, Joanna, Chober, Daniel, Parczewski, Miłosz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9000185/
https://www.ncbi.nlm.nih.gov/pubmed/35407496
http://dx.doi.org/10.3390/jcm11071887
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author Aksak-Wąs, Bogusz Jan
Urbańska, Anna
Scheibe, Kaja
Serwin, Karol
Leszczyszyn-Pynka, Magdalena
Rafalska-Kosior, Milena
Gołąb, Joanna
Chober, Daniel
Parczewski, Miłosz
author_facet Aksak-Wąs, Bogusz Jan
Urbańska, Anna
Scheibe, Kaja
Serwin, Karol
Leszczyszyn-Pynka, Magdalena
Rafalska-Kosior, Milena
Gołąb, Joanna
Chober, Daniel
Parczewski, Miłosz
author_sort Aksak-Wąs, Bogusz Jan
collection PubMed
description Introduction: Immune restoration is a key clinical aspect that is pursued in the care of human immunodeficiency virus (HIV)-infected patients. Despite effective antiretroviral treatment and undetectable viremia, immune recovery is often incomplete. Materials and methods: Data from 311 Caucasian patients were collected. SNP in CCR2(rs1799864), CX3CR1(rs3732378), HLAC-35(rs9264942), and CCR5(promoter, rs1799988); a 32bp deletion(Δ32) in CCR5; and HLA-B*5701 genotypes were correlated with clinical data and selected endpoints. Kaplan–Meier and Cox proportional hazards models were used to analyze the effects of genetic factors over time. Results: For HLA-B*5701, the effect on the CD4+/CD8+ >0.8 cell ratio was lost within 48 months (HR = 2.04, 95% CI: 1.04–4.03), and the effect on the CD4+ cell count >500 cells/µL was lost within 12 months (HR = 2.12, CI: 1.11–4.04). The effect of CCR2 GG on the CD4+/CD8+ >0.8 cell ratio was lost within 36 months (HR = 1.7, CI: 1.05–2.75). For CCR5 wt/Δ32, the effect on the CD4+/CD8+ >1.0 cell ratio was lost within 24 months (HR = 2.0, CI: 1.08–3.69), and the effect on the CD4+ >800 cells/µL cell count was lost within 18 months (HR = 1.98, CI: 1.14–4.73). Conclusions: Selected genetic polymorphisms, namely CCR2 GG and CCR5 Δ32, and the presence of the HLA-B*5701 allele positively influenced immune restoration in cART-treated patients with HIV/AIDS.
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spelling pubmed-90001852022-04-12 Factors Influencing Immune Restoration in People Living with HIV/AIDS Aksak-Wąs, Bogusz Jan Urbańska, Anna Scheibe, Kaja Serwin, Karol Leszczyszyn-Pynka, Magdalena Rafalska-Kosior, Milena Gołąb, Joanna Chober, Daniel Parczewski, Miłosz J Clin Med Article Introduction: Immune restoration is a key clinical aspect that is pursued in the care of human immunodeficiency virus (HIV)-infected patients. Despite effective antiretroviral treatment and undetectable viremia, immune recovery is often incomplete. Materials and methods: Data from 311 Caucasian patients were collected. SNP in CCR2(rs1799864), CX3CR1(rs3732378), HLAC-35(rs9264942), and CCR5(promoter, rs1799988); a 32bp deletion(Δ32) in CCR5; and HLA-B*5701 genotypes were correlated with clinical data and selected endpoints. Kaplan–Meier and Cox proportional hazards models were used to analyze the effects of genetic factors over time. Results: For HLA-B*5701, the effect on the CD4+/CD8+ >0.8 cell ratio was lost within 48 months (HR = 2.04, 95% CI: 1.04–4.03), and the effect on the CD4+ cell count >500 cells/µL was lost within 12 months (HR = 2.12, CI: 1.11–4.04). The effect of CCR2 GG on the CD4+/CD8+ >0.8 cell ratio was lost within 36 months (HR = 1.7, CI: 1.05–2.75). For CCR5 wt/Δ32, the effect on the CD4+/CD8+ >1.0 cell ratio was lost within 24 months (HR = 2.0, CI: 1.08–3.69), and the effect on the CD4+ >800 cells/µL cell count was lost within 18 months (HR = 1.98, CI: 1.14–4.73). Conclusions: Selected genetic polymorphisms, namely CCR2 GG and CCR5 Δ32, and the presence of the HLA-B*5701 allele positively influenced immune restoration in cART-treated patients with HIV/AIDS. MDPI 2022-03-28 /pmc/articles/PMC9000185/ /pubmed/35407496 http://dx.doi.org/10.3390/jcm11071887 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Aksak-Wąs, Bogusz Jan
Urbańska, Anna
Scheibe, Kaja
Serwin, Karol
Leszczyszyn-Pynka, Magdalena
Rafalska-Kosior, Milena
Gołąb, Joanna
Chober, Daniel
Parczewski, Miłosz
Factors Influencing Immune Restoration in People Living with HIV/AIDS
title Factors Influencing Immune Restoration in People Living with HIV/AIDS
title_full Factors Influencing Immune Restoration in People Living with HIV/AIDS
title_fullStr Factors Influencing Immune Restoration in People Living with HIV/AIDS
title_full_unstemmed Factors Influencing Immune Restoration in People Living with HIV/AIDS
title_short Factors Influencing Immune Restoration in People Living with HIV/AIDS
title_sort factors influencing immune restoration in people living with hiv/aids
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9000185/
https://www.ncbi.nlm.nih.gov/pubmed/35407496
http://dx.doi.org/10.3390/jcm11071887
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