Cargando…
shRNAs Targeting a Common KCNQ1 Variant Could Alleviate Long-QT1 Disease Severity by Inhibiting a Mutant Allele
Long-QT syndrome type 1 (LQT1) is caused by mutations in KCNQ1. Patients heterozygous for such a mutation co-assemble both mutant and wild-type KCNQ1-encoded subunits into tetrameric Kv7.1 potassium channels. Here, we investigated whether allele-specific inhibition of mutant KCNQ1 by targeting a com...
Autores principales: | Cócera-Ortega, Lucía, Wilders, Ronald, Kamps, Selina C., Fabrizi, Benedetta, Huber, Irit, van der Made, Ingeborg, van den Bout, Anouk, de Vries, Dylan K., Gepstein, Lior, Verkerk, Arie O., Pinto, Yigal M., Tijsen, Anke J. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9000197/ https://www.ncbi.nlm.nih.gov/pubmed/35409410 http://dx.doi.org/10.3390/ijms23074053 |
Ejemplares similares
-
Titin Circular RNAs Create a Back-Splice Motif Essential for SRSF10 Splicing
por: Tijsen, Anke J., et al.
Publicado: (2021) -
Generation of shRNAs from randomized oligonucleotides
por: Wu, Hailong, et al.
Publicado: (2007) -
Long QT Syndrome and Sinus Bradycardia–A Mini Review
por: Wilders, Ronald, et al.
Publicado: (2018) -
Towards Antiviral shRNAs Based on the AgoshRNA Design
por: Liu, Ying Poi, et al.
Publicado: (2015) -
Monitoring Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes with Genetically Encoded Calcium and Voltage Fluorescent Reporters
por: Shinnawi, Rami, et al.
Publicado: (2015)