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Physical Forces in Glioblastoma Migration: A Systematic Review
The invasive capabilities of glioblastoma (GBM) define the cancer’s aggressiveness, treatment resistance, and overall mortality. The tumor microenvironment influences the molecular behavior of cells, both epigenetically and genetically. Current forces being studied include properties of the extracel...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9000211/ https://www.ncbi.nlm.nih.gov/pubmed/35409420 http://dx.doi.org/10.3390/ijms23074055 |
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author | Grossen, Audrey Smith, Kyle Coulibaly, Nangorgo Arbuckle, Benjamin Evans, Alexander Wilhelm, Stefan Jones, Kenneth Dunn, Ian Towner, Rheal Wu, Dee Kim, Young-Tae Battiste, James |
author_facet | Grossen, Audrey Smith, Kyle Coulibaly, Nangorgo Arbuckle, Benjamin Evans, Alexander Wilhelm, Stefan Jones, Kenneth Dunn, Ian Towner, Rheal Wu, Dee Kim, Young-Tae Battiste, James |
author_sort | Grossen, Audrey |
collection | PubMed |
description | The invasive capabilities of glioblastoma (GBM) define the cancer’s aggressiveness, treatment resistance, and overall mortality. The tumor microenvironment influences the molecular behavior of cells, both epigenetically and genetically. Current forces being studied include properties of the extracellular matrix (ECM), such as stiffness and “sensing” capabilities. There is currently limited data on the physical forces in GBM—both relating to how they influence their environment and how their environment influences them. This review outlines the advances that have been made in the field. It is our hope that further investigation of the physical forces involved in GBM will highlight new therapeutic options and increase patient survival. A search of the PubMed database was conducted through to 23 March 2022 with the following search terms: (glioblastoma) AND (physical forces OR pressure OR shear forces OR compression OR tension OR torsion) AND (migration OR invasion). Our review yielded 11 external/applied/mechanical forces and 2 tumor microenvironment (TME) forces that affect the ability of GBM to locally migrate and invade. Both external forces and forces within the tumor microenvironment have been implicated in GBM migration, invasion, and treatment resistance. We endorse further research in this area to target the physical forces affecting the migration and invasion of GBM. |
format | Online Article Text |
id | pubmed-9000211 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-90002112022-04-12 Physical Forces in Glioblastoma Migration: A Systematic Review Grossen, Audrey Smith, Kyle Coulibaly, Nangorgo Arbuckle, Benjamin Evans, Alexander Wilhelm, Stefan Jones, Kenneth Dunn, Ian Towner, Rheal Wu, Dee Kim, Young-Tae Battiste, James Int J Mol Sci Review The invasive capabilities of glioblastoma (GBM) define the cancer’s aggressiveness, treatment resistance, and overall mortality. The tumor microenvironment influences the molecular behavior of cells, both epigenetically and genetically. Current forces being studied include properties of the extracellular matrix (ECM), such as stiffness and “sensing” capabilities. There is currently limited data on the physical forces in GBM—both relating to how they influence their environment and how their environment influences them. This review outlines the advances that have been made in the field. It is our hope that further investigation of the physical forces involved in GBM will highlight new therapeutic options and increase patient survival. A search of the PubMed database was conducted through to 23 March 2022 with the following search terms: (glioblastoma) AND (physical forces OR pressure OR shear forces OR compression OR tension OR torsion) AND (migration OR invasion). Our review yielded 11 external/applied/mechanical forces and 2 tumor microenvironment (TME) forces that affect the ability of GBM to locally migrate and invade. Both external forces and forces within the tumor microenvironment have been implicated in GBM migration, invasion, and treatment resistance. We endorse further research in this area to target the physical forces affecting the migration and invasion of GBM. MDPI 2022-04-06 /pmc/articles/PMC9000211/ /pubmed/35409420 http://dx.doi.org/10.3390/ijms23074055 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Grossen, Audrey Smith, Kyle Coulibaly, Nangorgo Arbuckle, Benjamin Evans, Alexander Wilhelm, Stefan Jones, Kenneth Dunn, Ian Towner, Rheal Wu, Dee Kim, Young-Tae Battiste, James Physical Forces in Glioblastoma Migration: A Systematic Review |
title | Physical Forces in Glioblastoma Migration: A Systematic Review |
title_full | Physical Forces in Glioblastoma Migration: A Systematic Review |
title_fullStr | Physical Forces in Glioblastoma Migration: A Systematic Review |
title_full_unstemmed | Physical Forces in Glioblastoma Migration: A Systematic Review |
title_short | Physical Forces in Glioblastoma Migration: A Systematic Review |
title_sort | physical forces in glioblastoma migration: a systematic review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9000211/ https://www.ncbi.nlm.nih.gov/pubmed/35409420 http://dx.doi.org/10.3390/ijms23074055 |
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