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Physical Forces in Glioblastoma Migration: A Systematic Review

The invasive capabilities of glioblastoma (GBM) define the cancer’s aggressiveness, treatment resistance, and overall mortality. The tumor microenvironment influences the molecular behavior of cells, both epigenetically and genetically. Current forces being studied include properties of the extracel...

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Autores principales: Grossen, Audrey, Smith, Kyle, Coulibaly, Nangorgo, Arbuckle, Benjamin, Evans, Alexander, Wilhelm, Stefan, Jones, Kenneth, Dunn, Ian, Towner, Rheal, Wu, Dee, Kim, Young-Tae, Battiste, James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9000211/
https://www.ncbi.nlm.nih.gov/pubmed/35409420
http://dx.doi.org/10.3390/ijms23074055
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author Grossen, Audrey
Smith, Kyle
Coulibaly, Nangorgo
Arbuckle, Benjamin
Evans, Alexander
Wilhelm, Stefan
Jones, Kenneth
Dunn, Ian
Towner, Rheal
Wu, Dee
Kim, Young-Tae
Battiste, James
author_facet Grossen, Audrey
Smith, Kyle
Coulibaly, Nangorgo
Arbuckle, Benjamin
Evans, Alexander
Wilhelm, Stefan
Jones, Kenneth
Dunn, Ian
Towner, Rheal
Wu, Dee
Kim, Young-Tae
Battiste, James
author_sort Grossen, Audrey
collection PubMed
description The invasive capabilities of glioblastoma (GBM) define the cancer’s aggressiveness, treatment resistance, and overall mortality. The tumor microenvironment influences the molecular behavior of cells, both epigenetically and genetically. Current forces being studied include properties of the extracellular matrix (ECM), such as stiffness and “sensing” capabilities. There is currently limited data on the physical forces in GBM—both relating to how they influence their environment and how their environment influences them. This review outlines the advances that have been made in the field. It is our hope that further investigation of the physical forces involved in GBM will highlight new therapeutic options and increase patient survival. A search of the PubMed database was conducted through to 23 March 2022 with the following search terms: (glioblastoma) AND (physical forces OR pressure OR shear forces OR compression OR tension OR torsion) AND (migration OR invasion). Our review yielded 11 external/applied/mechanical forces and 2 tumor microenvironment (TME) forces that affect the ability of GBM to locally migrate and invade. Both external forces and forces within the tumor microenvironment have been implicated in GBM migration, invasion, and treatment resistance. We endorse further research in this area to target the physical forces affecting the migration and invasion of GBM.
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spelling pubmed-90002112022-04-12 Physical Forces in Glioblastoma Migration: A Systematic Review Grossen, Audrey Smith, Kyle Coulibaly, Nangorgo Arbuckle, Benjamin Evans, Alexander Wilhelm, Stefan Jones, Kenneth Dunn, Ian Towner, Rheal Wu, Dee Kim, Young-Tae Battiste, James Int J Mol Sci Review The invasive capabilities of glioblastoma (GBM) define the cancer’s aggressiveness, treatment resistance, and overall mortality. The tumor microenvironment influences the molecular behavior of cells, both epigenetically and genetically. Current forces being studied include properties of the extracellular matrix (ECM), such as stiffness and “sensing” capabilities. There is currently limited data on the physical forces in GBM—both relating to how they influence their environment and how their environment influences them. This review outlines the advances that have been made in the field. It is our hope that further investigation of the physical forces involved in GBM will highlight new therapeutic options and increase patient survival. A search of the PubMed database was conducted through to 23 March 2022 with the following search terms: (glioblastoma) AND (physical forces OR pressure OR shear forces OR compression OR tension OR torsion) AND (migration OR invasion). Our review yielded 11 external/applied/mechanical forces and 2 tumor microenvironment (TME) forces that affect the ability of GBM to locally migrate and invade. Both external forces and forces within the tumor microenvironment have been implicated in GBM migration, invasion, and treatment resistance. We endorse further research in this area to target the physical forces affecting the migration and invasion of GBM. MDPI 2022-04-06 /pmc/articles/PMC9000211/ /pubmed/35409420 http://dx.doi.org/10.3390/ijms23074055 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Grossen, Audrey
Smith, Kyle
Coulibaly, Nangorgo
Arbuckle, Benjamin
Evans, Alexander
Wilhelm, Stefan
Jones, Kenneth
Dunn, Ian
Towner, Rheal
Wu, Dee
Kim, Young-Tae
Battiste, James
Physical Forces in Glioblastoma Migration: A Systematic Review
title Physical Forces in Glioblastoma Migration: A Systematic Review
title_full Physical Forces in Glioblastoma Migration: A Systematic Review
title_fullStr Physical Forces in Glioblastoma Migration: A Systematic Review
title_full_unstemmed Physical Forces in Glioblastoma Migration: A Systematic Review
title_short Physical Forces in Glioblastoma Migration: A Systematic Review
title_sort physical forces in glioblastoma migration: a systematic review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9000211/
https://www.ncbi.nlm.nih.gov/pubmed/35409420
http://dx.doi.org/10.3390/ijms23074055
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