Levonorgestrel Microneedle Array Patch for Sustained Release Contraception: Formulation, Optimization and In Vivo Characterization

Background: The goal of this work was to develop a levonorgestrel liposome-loaded microneedle array patch for contraception. Methods: Levonorgestrel-loaded liposome was formulated by a solvent injection technique, characterized, and studied. Results: The formulated liposomes were characterized for p...

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Autores principales: Rajput, Amarjitsing, Osmani, Riyaz Ali M., Khire, Achyut, Jaiswal, Sanket, Banerjee, Rinti
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9000369/
https://www.ncbi.nlm.nih.gov/pubmed/35408746
http://dx.doi.org/10.3390/molecules27072349
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author Rajput, Amarjitsing
Osmani, Riyaz Ali M.
Khire, Achyut
Jaiswal, Sanket
Banerjee, Rinti
author_facet Rajput, Amarjitsing
Osmani, Riyaz Ali M.
Khire, Achyut
Jaiswal, Sanket
Banerjee, Rinti
author_sort Rajput, Amarjitsing
collection PubMed
description Background: The goal of this work was to develop a levonorgestrel liposome-loaded microneedle array patch for contraception. Methods: Levonorgestrel-loaded liposome was formulated by a solvent injection technique, characterized, and studied. Results: The formulated liposomes were characterized for particle size (147 ± 8 nm), polydispersity index (0.207 ± 0.03), zeta potential (−23 ± 4.25 mV), drug loading (18 ± 3.22%) and entrapment efficiency (85 ± 4.34%). A cryo high-resolution transmission electron microscopy and cryo field emission gun scanning electron microscopy study showed spherical shaped particles with a smooth surface. The in vitro drug release and in vivo pharmacokinetic study showed sustained behaviour of Levonorgestrel for 28 days. Conclusion: The levonorgestrel liposome-loaded microneedle array patch showed better contraception than the drug-loaded microneedle array patch.
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spelling pubmed-90003692022-04-12 Levonorgestrel Microneedle Array Patch for Sustained Release Contraception: Formulation, Optimization and In Vivo Characterization Rajput, Amarjitsing Osmani, Riyaz Ali M. Khire, Achyut Jaiswal, Sanket Banerjee, Rinti Molecules Article Background: The goal of this work was to develop a levonorgestrel liposome-loaded microneedle array patch for contraception. Methods: Levonorgestrel-loaded liposome was formulated by a solvent injection technique, characterized, and studied. Results: The formulated liposomes were characterized for particle size (147 ± 8 nm), polydispersity index (0.207 ± 0.03), zeta potential (−23 ± 4.25 mV), drug loading (18 ± 3.22%) and entrapment efficiency (85 ± 4.34%). A cryo high-resolution transmission electron microscopy and cryo field emission gun scanning electron microscopy study showed spherical shaped particles with a smooth surface. The in vitro drug release and in vivo pharmacokinetic study showed sustained behaviour of Levonorgestrel for 28 days. Conclusion: The levonorgestrel liposome-loaded microneedle array patch showed better contraception than the drug-loaded microneedle array patch. MDPI 2022-04-06 /pmc/articles/PMC9000369/ /pubmed/35408746 http://dx.doi.org/10.3390/molecules27072349 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Rajput, Amarjitsing
Osmani, Riyaz Ali M.
Khire, Achyut
Jaiswal, Sanket
Banerjee, Rinti
Levonorgestrel Microneedle Array Patch for Sustained Release Contraception: Formulation, Optimization and In Vivo Characterization
title Levonorgestrel Microneedle Array Patch for Sustained Release Contraception: Formulation, Optimization and In Vivo Characterization
title_full Levonorgestrel Microneedle Array Patch for Sustained Release Contraception: Formulation, Optimization and In Vivo Characterization
title_fullStr Levonorgestrel Microneedle Array Patch for Sustained Release Contraception: Formulation, Optimization and In Vivo Characterization
title_full_unstemmed Levonorgestrel Microneedle Array Patch for Sustained Release Contraception: Formulation, Optimization and In Vivo Characterization
title_short Levonorgestrel Microneedle Array Patch for Sustained Release Contraception: Formulation, Optimization and In Vivo Characterization
title_sort levonorgestrel microneedle array patch for sustained release contraception: formulation, optimization and in vivo characterization
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9000369/
https://www.ncbi.nlm.nih.gov/pubmed/35408746
http://dx.doi.org/10.3390/molecules27072349
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