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Functional Polyion Complex Micelles for Potential Targeted Hydrophobic Drug Delivery

Polyion complex (PIC) micelles have gained an increasing interest, mainly as promising nano-vehicles for the delivery of various hydrophilic charged (macro)molecules such as DNA or drugs to the body. The aim of the present study is to construct novel functional PIC micelles bearing cell targeting li...

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Detalles Bibliográficos
Autores principales: Kalinova, Radostina, Dimitrov, Ivaylo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9000450/
https://www.ncbi.nlm.nih.gov/pubmed/35408579
http://dx.doi.org/10.3390/molecules27072178
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author Kalinova, Radostina
Dimitrov, Ivaylo
author_facet Kalinova, Radostina
Dimitrov, Ivaylo
author_sort Kalinova, Radostina
collection PubMed
description Polyion complex (PIC) micelles have gained an increasing interest, mainly as promising nano-vehicles for the delivery of various hydrophilic charged (macro)molecules such as DNA or drugs to the body. The aim of the present study is to construct novel functional PIC micelles bearing cell targeting ligands on the surface and to evaluate the possibility of a hydrophobic drug encapsulation. Initially, a pair of functional oppositely charged peptide-based hybrid diblock copolymers were synthesized and characterized. The copolymers spontaneously co-assembled in water into nanosized PIC micelles comprising a core of a polyelectrolyte complex between poly(L-aspartic acid) and poly(L-lysine) and a biocompatible mixed shell of disaccharide-modified poly(ethylene glycol) and poly(2-hydroxyethyl methacrylate). Depending on the molar ratio between the oppositely charged groups, PIC micelles varying in surface charge were obtained and loaded with the natural hydrophobic drug curcumin. PIC micelles’ drug loading efficiency, in vitro drug release profiles and antioxidant activity were evaluated. The preliminary results indicate that PIC micelles can be successfully used as carriers of hydrophobic drugs, thus expanding their potential application in nanomedicine.
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spelling pubmed-90004502022-04-12 Functional Polyion Complex Micelles for Potential Targeted Hydrophobic Drug Delivery Kalinova, Radostina Dimitrov, Ivaylo Molecules Article Polyion complex (PIC) micelles have gained an increasing interest, mainly as promising nano-vehicles for the delivery of various hydrophilic charged (macro)molecules such as DNA or drugs to the body. The aim of the present study is to construct novel functional PIC micelles bearing cell targeting ligands on the surface and to evaluate the possibility of a hydrophobic drug encapsulation. Initially, a pair of functional oppositely charged peptide-based hybrid diblock copolymers were synthesized and characterized. The copolymers spontaneously co-assembled in water into nanosized PIC micelles comprising a core of a polyelectrolyte complex between poly(L-aspartic acid) and poly(L-lysine) and a biocompatible mixed shell of disaccharide-modified poly(ethylene glycol) and poly(2-hydroxyethyl methacrylate). Depending on the molar ratio between the oppositely charged groups, PIC micelles varying in surface charge were obtained and loaded with the natural hydrophobic drug curcumin. PIC micelles’ drug loading efficiency, in vitro drug release profiles and antioxidant activity were evaluated. The preliminary results indicate that PIC micelles can be successfully used as carriers of hydrophobic drugs, thus expanding their potential application in nanomedicine. MDPI 2022-03-28 /pmc/articles/PMC9000450/ /pubmed/35408579 http://dx.doi.org/10.3390/molecules27072178 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kalinova, Radostina
Dimitrov, Ivaylo
Functional Polyion Complex Micelles for Potential Targeted Hydrophobic Drug Delivery
title Functional Polyion Complex Micelles for Potential Targeted Hydrophobic Drug Delivery
title_full Functional Polyion Complex Micelles for Potential Targeted Hydrophobic Drug Delivery
title_fullStr Functional Polyion Complex Micelles for Potential Targeted Hydrophobic Drug Delivery
title_full_unstemmed Functional Polyion Complex Micelles for Potential Targeted Hydrophobic Drug Delivery
title_short Functional Polyion Complex Micelles for Potential Targeted Hydrophobic Drug Delivery
title_sort functional polyion complex micelles for potential targeted hydrophobic drug delivery
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9000450/
https://www.ncbi.nlm.nih.gov/pubmed/35408579
http://dx.doi.org/10.3390/molecules27072178
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