Cargando…

Inhibition of Aldose Reductase by Ginsenoside Derivatives via a Specific Structure Activity Relationship with Kinetics Mechanism and Molecular Docking Study

This present work is designed to evaluate the anti-diabetic potential of 22 ginsenosides via the inhibition against rat lens aldose reductase (RLAR), and human recombinant aldose reductase (HRAR), using (DL)-glyceraldehyde as a substrate. Among the ginsenosides tested, ginsenoside Rh2, (20S) ginseno...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ali, Md Yousof, Zaib, Sumera, Jannat, Susoma, Khan, Imtiaz, Rahman, M. Mizanur, Park, Seong Kyu, Chang, Mun Seog
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9000482/ https://www.ncbi.nlm.nih.gov/pubmed/35408532 http://dx.doi.org/10.3390/molecules27072134

Ejemplares similares

Structural Bases for Hesperetin Derivatives: Inhibition of Protein Tyrosine Phosphatase 1B, Kinetics Mechanism and Molecular Docking Study
por: Ali, Md Yousof, et al.
Publicado: (2021)

Rhodanine-3-acetamide derivatives as aldose and aldehyde reductase inhibitors to treat diabetic complications: synthesis, biological evaluation, molecular docking and simulation studies
por: Bacha, Mohsinul Mulk, et al.
Publicado: (2021)

Molecular docking analysis of flavonoids with aldose reductase
por: Kannayiram, Kasthuri, et al.
Publicado: (2022)

Insulin–Mimetic Dihydroxanthyletin-Type Coumarins from Angelica decursiva with Protein Tyrosine Phosphatase 1B and α-Glucosidase Inhibitory Activities and Docking Studies of Their Molecular Mechanisms
por: Ali, Md Yousof, et al.
Publicado: (2021)

Virtual screening of plant derived compounds for aldose reductase inhibition using molecular docking
por: Muppalaneni, Naresh Babu, et al.
Publicado: (2012)

Physiological and Pathological Roles of Aldose Reductase
por: Singh, Mahavir, et al.
Publicado: (2021)

In Search of Differential Inhibitors of Aldose Reductase
por: Balestri, Francesco, et al.
Publicado: (2022)

Identification of Novel Aldose Reductase Inhibitors from Spices: A Molecular Docking and Simulation Study
por: Antony, Priya, et al.
Publicado: (2015)

Development and exploration of novel substituted thiosemicarbazones as inhibitors of aldose reductase via in vitro analysis and computational study
por: Imran, Aqeel, et al.
Publicado: (2022)

Structure of aldose reductase from Giardia lamblia
por: Ferrell, M., et al.
Publicado: (2011)

Aldose Reductase, Oxidative Stress, and Diabetic Mellitus
por: Tang, Wai Ho, et al.
Publicado: (2012)

Inhibition of Aldose Reductase by Gentiana lutea Extracts
por: Akileshwari, Chandrasekhar, et al.
Publicado: (2012)

Aldose Reductase Differential Inhibitors in Green Tea
por: Balestri, Francesco, et al.
Publicado: (2020)

Human aldose reductase unfolds through an intermediate
por: Sekhon, Gurprit, et al.
Publicado: (2019)

Dissecting the Activity of Catechins as Incomplete Aldose Reductase Differential Inhibitors through Kinetic and Computational Approaches
por: Balestri, Francesco, et al.
Publicado: (2022)

Protective Effects of Sweet Orange, Unshiu Mikan, and Mini Tomato Juice Powders on t-BHP-Induced Oxidative Stress in HepG2 Cells
por: Jannat, Susoma, et al.
Publicado: (2016)

Aldose Reductase Inhibitory Activity of Compounds from Zea mays L.
por: Kim, Tae Hyeon, et al.
Publicado: (2013)

The Inhibitory Effect of Prunella vulgaris L. on Aldose Reductase and Protein Glycation
por: Li, Hong Mei, et al.
Publicado: (2012)

Aldose Reductase Gene Polymorphisms and Diabetic Retinopathy Susceptibility
por: Abhary, Sotoodeh, et al.
Publicado: (2010)

Stereoselectivity of Aldose Reductase in the Reduction of Glutathionyl-Hydroxynonanal Adduct
por: Balestri, Francesco, et al.
Publicado: (2019)

Tracer metabolomics reveals the role of aldose reductase in glycosylation
por: Radenkovic, Silvia, et al.
Publicado: (2023)

Designing Next-Generation Drug-like Molecules for Medicinal Applications
por: Khan, Imtiaz, et al.
Publicado: (2023)

Three-dimensional quantitative structure-activity relationships and docking studies of some structurally diverse flavonoids and design of new aldose reductase inhibitors
por: Chandra De, Utpal, et al.
Publicado: (2015)

Models of enzyme inhibition and apparent dissociation constants from kinetic analysis to study the differential inhibition of aldose reductase
por: Balestri, Francesco, et al.
Publicado: (2022)

Erythrocyte aldose reductase activity and sorbitol levels in diabetic retinopathy
por: Reddy, G. Bhanuprakash, et al.
Publicado: (2008)

Aldose Reductase Inhibition Prevents Metaplasia of Airway Epithelial Cells
por: Yadav, Umesh C. S., et al.
Publicado: (2010)

Aldose reductase inhibitory activity and antioxidant capacity of pomegranate extracts
por: Karasu, Çimen, et al.
Publicado: (2012)

Epalrestat, an aldose reductase inhibitor, in diabetic neuropathy: An Indian perspective
por: Sharma, S. R., et al.
Publicado: (2008)

A New Approach to Control the Enigmatic Activity of Aldose Reductase
por: Del-Corso, Antonella, et al.
Publicado: (2013)

Inhibitory activities of selected Kampo formulations on human aldose reductase
por: Onoda, Toshihisa, et al.
Publicado: (2014)

Characterization of WY 14,643 and its Complex with Aldose Reductase
por: Sawaya, Michael R., et al.
Publicado: (2016)

Soyasaponins from Zolfino bean as aldose reductase differential inhibitors
por: Balestri, Francesco, et al.
Publicado: (2018)

General toxicity assessment of the novel aldose reductase inhibitor cemtirestat
por: PRNOVÁ, Marta ŠOLTÉSOVÁ, et al.
Publicado: (2019)

The Role of Aldose Reductase in Beta-Amyloid-Induced Microglia Activation
por: Huang, Yu-Kai, et al.
Publicado: (2022)

From LC-MS/MS metabolomics profiling of Kanchanara Guggulu to molecular docking and dynamics simulation of quercetin pentaacetate with aldose reductase
por: Behera, Santosh Kumar, et al.
Publicado: (2021)

Cardiomyocyte Aldose Reductase Causes Heart Failure and Impairs Recovery from Ischemia
por: Son, Ni-Huiping, et al.
Publicado: (2012)

Inhibition of Aldose Reductase Prevents Experimental Allergic Airway Inflammation in Mice
por: Yadav, Umesh C. S., et al.
Publicado: (2009)

Aldose Reductase Is Involved in the Development of Murine Diet-Induced Nonalcoholic Steatohepatitis
por: Qiu, Longxin, et al.
Publicado: (2013)

Aldose reductase participates in the downregulation of T cell functions due to suppressor macrophages
por: Shimizu, Toshiaki, et al.
Publicado: (2016)

Rapid Identification of Aldose Reductase Inhibitory Compounds from Perilla frutescens
por: Paek, Ji Hun, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_4hq1fnodgm6lh52pf730q1ja4n