Cargando…

OTOP2, Inversely Modulated by miR-3148, Inhibits CRC Cell Migration, Proliferation and Epithelial–Mesenchymal Transition: Evidence from Bioinformatics Data Mining and Experimental Verification

INTRODUCTION: Colorectal cancer (CRC) represents one of the most frequent human malignancies with its underlying pathogenesis still unclear. The prevalence of multi-omics in screening biomarkers associated with CRC has largely accelerated our understanding into the pathophysiology of CRC. The presen...

Descripción completa

Detalles Bibliográficos
Autores principales:	Guo, Shuai, Sun, Yang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2022
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9000554/ https://www.ncbi.nlm.nih.gov/pubmed/35418782 http://dx.doi.org/10.2147/CMAR.S345299

Ejemplares similares

Structures of the Otopetrin Proton Channels Otop1 and Otop3
por: Saotome, Kei, et al.
Publicado: (2019)

Vertebrate OTOP1 is also an alkali-activated channel
por: Tian, Lifeng, et al.
Publicado: (2023)

The proton channel OTOP1 is a sensor for the taste of ammonium chloride
por: Liang, Ziyu, et al.
Publicado: (2023)

Zinc activation of OTOP proton channels identifies structural elements of the gating apparatus
por: Teng, Bochuan, et al.
Publicado: (2023)

MicroRNA-3148 modulates differential gene expression of the SLE-associated TLR7 variant
por: Deng, Y, et al.
Publicado: (2012)

Wnt3a promotes epithelial–mesenchymal transition, migration, and proliferation of lens epithelial cells
por: Bao, Xiu-li, et al.
Publicado: (2012)

The roles of two extracellular loops in proton sensing and permeation in human Otop1 proton channel
por: Li, Bin, et al.
Publicado: (2022)

RGC32 induces epithelial-mesenchymal transition by activating the Smad/Sip1 signaling pathway in CRC
por: Wang, Xiao-Yan, et al.
Publicado: (2017)

20(S)-ginsenoside Rh2 as agent for the treatment of LMN-CRC via regulating epithelial–mesenchymal transition
por: Yuan, Yihang, et al.
Publicado: (2020)

Osteopontin Splicing Isoforms Contribute to Endometriotic Proliferation, Migration, and Epithelial-Mesenchymal Transition in Endometrial Epithelial Cells
por: Ho, Nguyen-Tuong, et al.
Publicado: (2022)

Overexpression of TAZ promotes cell proliferation, migration and epithelial-mesenchymal transition in ovarian cancer
por: Chen, Guangyuan, et al.
Publicado: (2016)

FOXA2 promotes the proliferation, migration and invasion, and epithelial mesenchymal transition in colon cancer
por: Wang, Baolei, et al.
Publicado: (2018)

MicroRNA-3148 Modulates Allelic Expression of Toll-Like Receptor 7 Variant Associated with Systemic Lupus Erythematosus
por: Deng, Yun, et al.
Publicado: (2013)

MicroRNA-3148 inhibits glioma by decreasing DCUN1D1 and inhibiting the NF-kB pathway
por: Xu, Qianghua, et al.
Publicado: (2022)

TSPAN7 promotes the migration and proliferation of lung cancer cells via epithelial-to-mesenchymal transition
por: Wang, Xianguo, et al.
Publicado: (2018)

The Effect of GPX2 on the Prognosis of Lung Adenocarcinoma Diagnosis and Proliferation, Migration, and Epithelial Mesenchymal Transition
por: Li, Yu-peng, et al.
Publicado: (2022)

The transmembrane proteins (TMEM) and their role in cell proliferation, migration, invasion, and epithelial-mesenchymal transition in cancer
por: Herrera-Quiterio, Gloria Angelina, et al.
Publicado: (2023)

The role of DYNLT3 in breast cancer proliferation, migration, and invasion via epithelial‐to‐mesenchymal transition
por: Wang, Han, et al.
Publicado: (2023)

Bioinformatic analysis reveals the importance of epithelial-mesenchymal transition in the development of endometriosis
por: Chen, Meihong, et al.
Publicado: (2020)

Collective and Individual Migration following the Epithelial-Mesenchymal Transition
por: Wong, Ian Y., et al.
Publicado: (2014)

Silencing SOX2 Induced Mesenchymal-Epithelial Transition and Its Expression Predicts Liver and Lymph Node Metastasis of CRC Patients
por: Han, Xu, et al.
Publicado: (2012)

DcR3 induces epithelial-mesenchymal transition through activation of the TGF-β3/SMAD signaling pathway in CRC
por: Liu, Yan-Ping, et al.
Publicado: (2016)

RAMS11 promotes CRC through mTOR-dependent inhibition of autophagy, suppression of apoptosis, and promotion of epithelial-mesenchymal transition
por: Islam Khan, Md Zahirul, et al.
Publicado: (2021)

Stress-induced epinephrine promotes epithelial-to-mesenchymal transition and stemness of CRC through the CEBPB/TRIM2/P53 axis
por: Zhou, Zili, et al.
Publicado: (2022)

Wild‐type p53 regulates OTOP2 transcription through DNA loop alteration of the promoter in colorectal cancer
por: Qu, Huajun, et al.
Publicado: (2018)

Bortezomib inhibits proliferation, migration, and TGF-β1–induced epithelial–mesenchymal transition of RPE cells
por: Moon, Kun, et al.
Publicado: (2017)

Yeast-Derived Recombinant Avenanthramides Inhibit Proliferation, Migration and Epithelial Mesenchymal Transition of Colon Cancer Cells
por: Finetti, Federica, et al.
Publicado: (2018)

MeCP2 inhibits proliferation and migration of breast cancer via suppression of epithelial‐mesenchymal transition
por: Jiang, Wei, et al.
Publicado: (2020)

Laminin-332 mediates proliferation, apoptosis, invasion, migration and epithelial-to-mesenchymal transition in pancreatic ductal adenocarcinoma
por: Huang, Caiqun, et al.
Publicado: (2021)

Downregulation of FOXO6 in breast cancer promotes epithelial–mesenchymal transition and facilitates migration and proliferation of cancer cells
por: Ye, Hui, et al.
Publicado: (2018)

Effects of activating GABAB1 receptor on proliferation, migration, invasion and epithelial-mesenchymal transition of ovarian cancer cells
por: Gao, Jun, et al.
Publicado: (2020)

AKR1B10 inhibits the proliferation and migration of gastric cancer via regulating epithelial-mesenchymal transition
por: Shao, Xinyu, et al.
Publicado: (2021)

LINC00958 promotes proliferation, migration, invasion, and epithelial-mesenchymal transition of oesophageal squamous cell carcinoma cells
por: Wang, Biqi, et al.
Publicado: (2021)

Nucleobindin‐2/nesfatin‐1 enhances the cell proliferation, migration, invasion and epithelial‐mesenchymal transition in gastric carcinoma
por: Ren, Le, et al.
Publicado: (2022)

Downregulation of KIAA1199 alleviated the activation, proliferation, and migration of hepatic stellate cells by the inhibition of epithelial–mesenchymal transition
por: Liu, Jingmei, et al.
Publicado: (2023)

MicroRNA-221 Mediates the Effects of PDGF-BB on Migration, Proliferation, and the Epithelial-Mesenchymal Transition in Pancreatic Cancer Cells
por: Su, Anping, et al.
Publicado: (2013)

miR-4429 Regulates the Proliferation, Migration, Invasion, and Epithelial-Mesenchymal Transition of Cervical Cancer by Targeting FOXM1
por: Liang, Lin, et al.
Publicado: (2020)

Knockdown of Thymidine Kinase 1 Suppresses Cell Proliferation, Invasion, Migration, and Epithelial–Mesenchymal Transition in Thyroid Carcinoma Cells
por: Liu, Chang, et al.
Publicado: (2020)

High STRN Expression Promotes HCC Invasion and Migration but Not Cell Proliferation or Apoptosis through Facilitating Epithelial-Mesenchymal Transition
por: Du, Qian-yu, et al.
Publicado: (2020)

Cyclin F Downregulation Affects Epithelial-Mesenchymal Transition Increasing Proliferation and Migration of the A-375 Melanoma Cell Line
por: Krajewski, Adrian, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_dcevh9e3ga2er16t58e60m7fln