Cargando…
Dittrichia viscosa L. Leaves: A Valuable Source of Bioactive Compounds with Multiple Pharmacological Effects
This work focused on the leaves of Dittrichia viscosa, a plant used in Mediterranean folk medicine. Compared to water extract, the methanolic extract had higher antioxidant effects. Moreover, this extract showed potent in vitro inhibitory activity against α-amylase and α-glucosidase and showed an in...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9000642/ https://www.ncbi.nlm.nih.gov/pubmed/35408507 http://dx.doi.org/10.3390/molecules27072108 |
_version_ | 1784685484561137664 |
---|---|
author | Mrid, Reda Ben Bouchmaa, Najat Kabach, Imad Zouaoui, Zakia Chtibi, Houda Maadoudi, Mohammed El Kounnoun, Ayoub Cacciola, Francesco Majdoub, Yassine Oulad El Mondello, Luigi Zyad, Abdelmajid Nhiri, Mohamed |
author_facet | Mrid, Reda Ben Bouchmaa, Najat Kabach, Imad Zouaoui, Zakia Chtibi, Houda Maadoudi, Mohammed El Kounnoun, Ayoub Cacciola, Francesco Majdoub, Yassine Oulad El Mondello, Luigi Zyad, Abdelmajid Nhiri, Mohamed |
author_sort | Mrid, Reda Ben |
collection | PubMed |
description | This work focused on the leaves of Dittrichia viscosa, a plant used in Mediterranean folk medicine. Compared to water extract, the methanolic extract had higher antioxidant effects. Moreover, this extract showed potent in vitro inhibitory activity against α-amylase and α-glucosidase and showed an interesting antiglycation effect. Additionally, the evaluation of the cytotoxic activity of the methanolic extract against two human breast cancer cell lines, MCF-7 and MDA-MB-468, was very promising, with no cytotoxicity towards normal cells (peripheral blood mononuclear cells (PBMCs). The antibacterial effect was also assessed and showed potent inhibitory activity against Proteus mirabilis and Bacillus subtilis. On the other hand, Dittrichia viscosa leaves were rich in macro-elements containing appropriate micro-elements and high levels of phenolics and flavonoids such as caffeic acid derivatives. Taken together, the results obtained in this study indicate that Dittrichia viscosa could constitute a valuable source of bioactive molecules and could be used either on the preventive side or for therapeutic applications without toxicity. |
format | Online Article Text |
id | pubmed-9000642 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-90006422022-04-12 Dittrichia viscosa L. Leaves: A Valuable Source of Bioactive Compounds with Multiple Pharmacological Effects Mrid, Reda Ben Bouchmaa, Najat Kabach, Imad Zouaoui, Zakia Chtibi, Houda Maadoudi, Mohammed El Kounnoun, Ayoub Cacciola, Francesco Majdoub, Yassine Oulad El Mondello, Luigi Zyad, Abdelmajid Nhiri, Mohamed Molecules Article This work focused on the leaves of Dittrichia viscosa, a plant used in Mediterranean folk medicine. Compared to water extract, the methanolic extract had higher antioxidant effects. Moreover, this extract showed potent in vitro inhibitory activity against α-amylase and α-glucosidase and showed an interesting antiglycation effect. Additionally, the evaluation of the cytotoxic activity of the methanolic extract against two human breast cancer cell lines, MCF-7 and MDA-MB-468, was very promising, with no cytotoxicity towards normal cells (peripheral blood mononuclear cells (PBMCs). The antibacterial effect was also assessed and showed potent inhibitory activity against Proteus mirabilis and Bacillus subtilis. On the other hand, Dittrichia viscosa leaves were rich in macro-elements containing appropriate micro-elements and high levels of phenolics and flavonoids such as caffeic acid derivatives. Taken together, the results obtained in this study indicate that Dittrichia viscosa could constitute a valuable source of bioactive molecules and could be used either on the preventive side or for therapeutic applications without toxicity. MDPI 2022-03-24 /pmc/articles/PMC9000642/ /pubmed/35408507 http://dx.doi.org/10.3390/molecules27072108 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Mrid, Reda Ben Bouchmaa, Najat Kabach, Imad Zouaoui, Zakia Chtibi, Houda Maadoudi, Mohammed El Kounnoun, Ayoub Cacciola, Francesco Majdoub, Yassine Oulad El Mondello, Luigi Zyad, Abdelmajid Nhiri, Mohamed Dittrichia viscosa L. Leaves: A Valuable Source of Bioactive Compounds with Multiple Pharmacological Effects |
title | Dittrichia viscosa L. Leaves: A Valuable Source of Bioactive Compounds with Multiple Pharmacological Effects |
title_full | Dittrichia viscosa L. Leaves: A Valuable Source of Bioactive Compounds with Multiple Pharmacological Effects |
title_fullStr | Dittrichia viscosa L. Leaves: A Valuable Source of Bioactive Compounds with Multiple Pharmacological Effects |
title_full_unstemmed | Dittrichia viscosa L. Leaves: A Valuable Source of Bioactive Compounds with Multiple Pharmacological Effects |
title_short | Dittrichia viscosa L. Leaves: A Valuable Source of Bioactive Compounds with Multiple Pharmacological Effects |
title_sort | dittrichia viscosa l. leaves: a valuable source of bioactive compounds with multiple pharmacological effects |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9000642/ https://www.ncbi.nlm.nih.gov/pubmed/35408507 http://dx.doi.org/10.3390/molecules27072108 |
work_keys_str_mv | AT mridredaben dittrichiaviscosalleavesavaluablesourceofbioactivecompoundswithmultiplepharmacologicaleffects AT bouchmaanajat dittrichiaviscosalleavesavaluablesourceofbioactivecompoundswithmultiplepharmacologicaleffects AT kabachimad dittrichiaviscosalleavesavaluablesourceofbioactivecompoundswithmultiplepharmacologicaleffects AT zouaouizakia dittrichiaviscosalleavesavaluablesourceofbioactivecompoundswithmultiplepharmacologicaleffects AT chtibihouda dittrichiaviscosalleavesavaluablesourceofbioactivecompoundswithmultiplepharmacologicaleffects AT maadoudimohammedel dittrichiaviscosalleavesavaluablesourceofbioactivecompoundswithmultiplepharmacologicaleffects AT kounnounayoub dittrichiaviscosalleavesavaluablesourceofbioactivecompoundswithmultiplepharmacologicaleffects AT cacciolafrancesco dittrichiaviscosalleavesavaluablesourceofbioactivecompoundswithmultiplepharmacologicaleffects AT majdoubyassineouladel dittrichiaviscosalleavesavaluablesourceofbioactivecompoundswithmultiplepharmacologicaleffects AT mondelloluigi dittrichiaviscosalleavesavaluablesourceofbioactivecompoundswithmultiplepharmacologicaleffects AT zyadabdelmajid dittrichiaviscosalleavesavaluablesourceofbioactivecompoundswithmultiplepharmacologicaleffects AT nhirimohamed dittrichiaviscosalleavesavaluablesourceofbioactivecompoundswithmultiplepharmacologicaleffects |