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Structure and Biological Activity of Ergostane-Type Steroids from Fungi
Mushrooms are known not only for their taste but also for beneficial effects on health attributed to plethora of constituents. All mushrooms belong to the kingdom of fungi, which also includes yeasts and molds. Each year, hundreds of new metabolites of the main fungal sterol, ergosterol, are isolate...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9000798/ https://www.ncbi.nlm.nih.gov/pubmed/35408501 http://dx.doi.org/10.3390/molecules27072103 |
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author | Zhabinskii, Vladimir N. Drasar, Pavel Khripach, Vladimir A. |
author_facet | Zhabinskii, Vladimir N. Drasar, Pavel Khripach, Vladimir A. |
author_sort | Zhabinskii, Vladimir N. |
collection | PubMed |
description | Mushrooms are known not only for their taste but also for beneficial effects on health attributed to plethora of constituents. All mushrooms belong to the kingdom of fungi, which also includes yeasts and molds. Each year, hundreds of new metabolites of the main fungal sterol, ergosterol, are isolated from fungal sources. As a rule, further testing is carried out for their biological effects, and many of the isolated compounds exhibit one or another activity. This study aims to review recent literature (mainly over the past 10 years, selected older works are discussed for consistency purposes) on the structures and bioactivities of fungal metabolites of ergosterol. The review is not exhaustive in its coverage of structures found in fungi. Rather, it focuses solely on discussing compounds that have shown some biological activity with potential pharmacological utility. |
format | Online Article Text |
id | pubmed-9000798 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-90007982022-04-12 Structure and Biological Activity of Ergostane-Type Steroids from Fungi Zhabinskii, Vladimir N. Drasar, Pavel Khripach, Vladimir A. Molecules Review Mushrooms are known not only for their taste but also for beneficial effects on health attributed to plethora of constituents. All mushrooms belong to the kingdom of fungi, which also includes yeasts and molds. Each year, hundreds of new metabolites of the main fungal sterol, ergosterol, are isolated from fungal sources. As a rule, further testing is carried out for their biological effects, and many of the isolated compounds exhibit one or another activity. This study aims to review recent literature (mainly over the past 10 years, selected older works are discussed for consistency purposes) on the structures and bioactivities of fungal metabolites of ergosterol. The review is not exhaustive in its coverage of structures found in fungi. Rather, it focuses solely on discussing compounds that have shown some biological activity with potential pharmacological utility. MDPI 2022-03-24 /pmc/articles/PMC9000798/ /pubmed/35408501 http://dx.doi.org/10.3390/molecules27072103 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Zhabinskii, Vladimir N. Drasar, Pavel Khripach, Vladimir A. Structure and Biological Activity of Ergostane-Type Steroids from Fungi |
title | Structure and Biological Activity of Ergostane-Type Steroids from Fungi |
title_full | Structure and Biological Activity of Ergostane-Type Steroids from Fungi |
title_fullStr | Structure and Biological Activity of Ergostane-Type Steroids from Fungi |
title_full_unstemmed | Structure and Biological Activity of Ergostane-Type Steroids from Fungi |
title_short | Structure and Biological Activity of Ergostane-Type Steroids from Fungi |
title_sort | structure and biological activity of ergostane-type steroids from fungi |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9000798/ https://www.ncbi.nlm.nih.gov/pubmed/35408501 http://dx.doi.org/10.3390/molecules27072103 |
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