Cargando…

Structure and Biological Activity of Ergostane-Type Steroids from Fungi

Mushrooms are known not only for their taste but also for beneficial effects on health attributed to plethora of constituents. All mushrooms belong to the kingdom of fungi, which also includes yeasts and molds. Each year, hundreds of new metabolites of the main fungal sterol, ergosterol, are isolate...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhabinskii, Vladimir N., Drasar, Pavel, Khripach, Vladimir A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9000798/
https://www.ncbi.nlm.nih.gov/pubmed/35408501
http://dx.doi.org/10.3390/molecules27072103
_version_ 1784685524310556672
author Zhabinskii, Vladimir N.
Drasar, Pavel
Khripach, Vladimir A.
author_facet Zhabinskii, Vladimir N.
Drasar, Pavel
Khripach, Vladimir A.
author_sort Zhabinskii, Vladimir N.
collection PubMed
description Mushrooms are known not only for their taste but also for beneficial effects on health attributed to plethora of constituents. All mushrooms belong to the kingdom of fungi, which also includes yeasts and molds. Each year, hundreds of new metabolites of the main fungal sterol, ergosterol, are isolated from fungal sources. As a rule, further testing is carried out for their biological effects, and many of the isolated compounds exhibit one or another activity. This study aims to review recent literature (mainly over the past 10 years, selected older works are discussed for consistency purposes) on the structures and bioactivities of fungal metabolites of ergosterol. The review is not exhaustive in its coverage of structures found in fungi. Rather, it focuses solely on discussing compounds that have shown some biological activity with potential pharmacological utility.
format Online
Article
Text
id pubmed-9000798
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-90007982022-04-12 Structure and Biological Activity of Ergostane-Type Steroids from Fungi Zhabinskii, Vladimir N. Drasar, Pavel Khripach, Vladimir A. Molecules Review Mushrooms are known not only for their taste but also for beneficial effects on health attributed to plethora of constituents. All mushrooms belong to the kingdom of fungi, which also includes yeasts and molds. Each year, hundreds of new metabolites of the main fungal sterol, ergosterol, are isolated from fungal sources. As a rule, further testing is carried out for their biological effects, and many of the isolated compounds exhibit one or another activity. This study aims to review recent literature (mainly over the past 10 years, selected older works are discussed for consistency purposes) on the structures and bioactivities of fungal metabolites of ergosterol. The review is not exhaustive in its coverage of structures found in fungi. Rather, it focuses solely on discussing compounds that have shown some biological activity with potential pharmacological utility. MDPI 2022-03-24 /pmc/articles/PMC9000798/ /pubmed/35408501 http://dx.doi.org/10.3390/molecules27072103 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zhabinskii, Vladimir N.
Drasar, Pavel
Khripach, Vladimir A.
Structure and Biological Activity of Ergostane-Type Steroids from Fungi
title Structure and Biological Activity of Ergostane-Type Steroids from Fungi
title_full Structure and Biological Activity of Ergostane-Type Steroids from Fungi
title_fullStr Structure and Biological Activity of Ergostane-Type Steroids from Fungi
title_full_unstemmed Structure and Biological Activity of Ergostane-Type Steroids from Fungi
title_short Structure and Biological Activity of Ergostane-Type Steroids from Fungi
title_sort structure and biological activity of ergostane-type steroids from fungi
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9000798/
https://www.ncbi.nlm.nih.gov/pubmed/35408501
http://dx.doi.org/10.3390/molecules27072103
work_keys_str_mv AT zhabinskiivladimirn structureandbiologicalactivityofergostanetypesteroidsfromfungi
AT drasarpavel structureandbiologicalactivityofergostanetypesteroidsfromfungi
AT khripachvladimira structureandbiologicalactivityofergostanetypesteroidsfromfungi