Insights on the Synthesis of N-Heterocycles Containing Macrocycles and Their Complexion and Biological Properties

Macrocyclic chemistry has been extensively developed over the past several decades. In fact, the architecture of new macrocyclic models has undergone exponential growth to offer molecules with specific properties. In this context, an attempt is made in this study to provide an overview of some synth...

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Detalles Bibliográficos
Autores principales: Malek, Fouad, Harit, Tarik, Cherfi, Mounir, Kim, Bonglee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9000807/
https://www.ncbi.nlm.nih.gov/pubmed/35408522
http://dx.doi.org/10.3390/molecules27072123
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author Malek, Fouad
Harit, Tarik
Cherfi, Mounir
Kim, Bonglee
author_facet Malek, Fouad
Harit, Tarik
Cherfi, Mounir
Kim, Bonglee
author_sort Malek, Fouad
collection PubMed
description Macrocyclic chemistry has been extensively developed over the past several decades. In fact, the architecture of new macrocyclic models has undergone exponential growth to offer molecules with specific properties. In this context, an attempt is made in this study to provide an overview of some synthetic methods allowing the elaboration of N-heterocycles containing macrocycles (imidazole, triazole, tetrazole, and pyrazole), as well as their applications in the complexation of metal cations or as pharmacological agents.
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spelling pubmed-90008072022-04-12 Insights on the Synthesis of N-Heterocycles Containing Macrocycles and Their Complexion and Biological Properties Malek, Fouad Harit, Tarik Cherfi, Mounir Kim, Bonglee Molecules Review Macrocyclic chemistry has been extensively developed over the past several decades. In fact, the architecture of new macrocyclic models has undergone exponential growth to offer molecules with specific properties. In this context, an attempt is made in this study to provide an overview of some synthetic methods allowing the elaboration of N-heterocycles containing macrocycles (imidazole, triazole, tetrazole, and pyrazole), as well as their applications in the complexation of metal cations or as pharmacological agents. MDPI 2022-03-25 /pmc/articles/PMC9000807/ /pubmed/35408522 http://dx.doi.org/10.3390/molecules27072123 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Malek, Fouad
Harit, Tarik
Cherfi, Mounir
Kim, Bonglee
Insights on the Synthesis of N-Heterocycles Containing Macrocycles and Their Complexion and Biological Properties
title Insights on the Synthesis of N-Heterocycles Containing Macrocycles and Their Complexion and Biological Properties
title_full Insights on the Synthesis of N-Heterocycles Containing Macrocycles and Their Complexion and Biological Properties
title_fullStr Insights on the Synthesis of N-Heterocycles Containing Macrocycles and Their Complexion and Biological Properties
title_full_unstemmed Insights on the Synthesis of N-Heterocycles Containing Macrocycles and Their Complexion and Biological Properties
title_short Insights on the Synthesis of N-Heterocycles Containing Macrocycles and Their Complexion and Biological Properties
title_sort insights on the synthesis of n-heterocycles containing macrocycles and their complexion and biological properties
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9000807/
https://www.ncbi.nlm.nih.gov/pubmed/35408522
http://dx.doi.org/10.3390/molecules27072123
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