Cryo-ET of Env on intact HIV virions reveals structural variation and positioning on the Gag lattice

HIV-1 Env mediates viral entry into host cells and is the sole target for neutralizing antibodies. However, Env structure and organization in its native virion context has eluded detailed characterization. Here, we used cryo-electron tomography to analyze Env in mature and immature HIV-1 particles....

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Detalles Bibliográficos
Autores principales: Mangala Prasad, Vidya, Leaman, Daniel P., Lovendahl, Klaus N., Croft, Jacob T., Benhaim, Mark A., Hodge, Edgar A., Zwick, Michael B., Lee, Kelly K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9000915/
https://www.ncbi.nlm.nih.gov/pubmed/35123651
http://dx.doi.org/10.1016/j.cell.2022.01.013

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