Hinokitiol Protects Cardiomyocyte from Oxidative Damage by Inhibiting GSK3β-Mediated Autophagy

More and more attention has been paid to the use of traditional phytochemicals. Here, we first verified the therapeutic potential of a natural bioactive compound called Hinokitiol in myocardial ischemia reperfusion injury. Hinokitiol exerts cardioprotective effect through inhibition of GSK-3β and su...

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Detalles Bibliográficos
Autores principales: Xiao, Hongkai, Liang, Siyu, Cai, Qinhong, Liu, Jinghu, Jin, Liang, Yang, Zhengfei, Chen, Xiaochao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9001072/
https://www.ncbi.nlm.nih.gov/pubmed/35419165
http://dx.doi.org/10.1155/2022/2700000
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author Xiao, Hongkai
Liang, Siyu
Cai, Qinhong
Liu, Jinghu
Jin, Liang
Yang, Zhengfei
Chen, Xiaochao
author_facet Xiao, Hongkai
Liang, Siyu
Cai, Qinhong
Liu, Jinghu
Jin, Liang
Yang, Zhengfei
Chen, Xiaochao
author_sort Xiao, Hongkai
collection PubMed
description More and more attention has been paid to the use of traditional phytochemicals. Here, we first verified the therapeutic potential of a natural bioactive compound called Hinokitiol in myocardial ischemia reperfusion injury. Hinokitiol exerts cardioprotective effect through inhibition of GSK-3β and subsequent elimination of excessive autophagy, tuning autophagic activity in moderate extent for remedial profit in acute myocardial infarction and myocardial ischemia reperfusion injury. Overall, our study establishes Hinokitiol as a novel available interventional treatment for myocardial ischemia reperfusion injury.
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spelling pubmed-90010722022-04-12 Hinokitiol Protects Cardiomyocyte from Oxidative Damage by Inhibiting GSK3β-Mediated Autophagy Xiao, Hongkai Liang, Siyu Cai, Qinhong Liu, Jinghu Jin, Liang Yang, Zhengfei Chen, Xiaochao Oxid Med Cell Longev Research Article More and more attention has been paid to the use of traditional phytochemicals. Here, we first verified the therapeutic potential of a natural bioactive compound called Hinokitiol in myocardial ischemia reperfusion injury. Hinokitiol exerts cardioprotective effect through inhibition of GSK-3β and subsequent elimination of excessive autophagy, tuning autophagic activity in moderate extent for remedial profit in acute myocardial infarction and myocardial ischemia reperfusion injury. Overall, our study establishes Hinokitiol as a novel available interventional treatment for myocardial ischemia reperfusion injury. Hindawi 2022-04-04 /pmc/articles/PMC9001072/ /pubmed/35419165 http://dx.doi.org/10.1155/2022/2700000 Text en Copyright © 2022 Hongkai Xiao et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Xiao, Hongkai
Liang, Siyu
Cai, Qinhong
Liu, Jinghu
Jin, Liang
Yang, Zhengfei
Chen, Xiaochao
Hinokitiol Protects Cardiomyocyte from Oxidative Damage by Inhibiting GSK3β-Mediated Autophagy
title Hinokitiol Protects Cardiomyocyte from Oxidative Damage by Inhibiting GSK3β-Mediated Autophagy
title_full Hinokitiol Protects Cardiomyocyte from Oxidative Damage by Inhibiting GSK3β-Mediated Autophagy
title_fullStr Hinokitiol Protects Cardiomyocyte from Oxidative Damage by Inhibiting GSK3β-Mediated Autophagy
title_full_unstemmed Hinokitiol Protects Cardiomyocyte from Oxidative Damage by Inhibiting GSK3β-Mediated Autophagy
title_short Hinokitiol Protects Cardiomyocyte from Oxidative Damage by Inhibiting GSK3β-Mediated Autophagy
title_sort hinokitiol protects cardiomyocyte from oxidative damage by inhibiting gsk3β-mediated autophagy
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9001072/
https://www.ncbi.nlm.nih.gov/pubmed/35419165
http://dx.doi.org/10.1155/2022/2700000
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