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NEDD9 sustains hexokinase expression to promote glycolysis

Elevated rates of glycolysis in cancer cells support tumor growth, in a process that typically depends on oncogene-induced increases in the expression and/or activity of enzymes in the glycolytic pathway. The NEDD9 scaffolding protein is upregulated in many advanced tumors, with increased NEDD9 prom...

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Detalles Bibliográficos
Autores principales: Deneka, Alexander Y., Nikonova, Anna S., Lee, Hyung-Ok, Kruger, Warren D., Golemis, Erica A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9001639/
https://www.ncbi.nlm.nih.gov/pubmed/35410460
http://dx.doi.org/10.1038/s41389-022-00391-w