Ubiquitin-like protein 3 (UBL3) is required for MARCH ubiquitination of major histocompatibility complex class II and CD86

The MARCH E3 ubiquitin (Ub) ligase MARCH1 regulates trafficking of major histocompatibility complex class II (MHC II) and CD86, molecules of critical importance to immunity. Here we show, using a genome-wide CRISPR knockout screen, that ubiquitin-like protein 3 (UBL3) is a necessary component of ubi...

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Detalles Bibliográficos
Autores principales: Liu, Haiyin, Wilson, Kayla R., Firth, Ashley M., Macri, Christophe, Schriek, Patrick, Blum, Annabelle B., Villar, Javiera, Wormald, Samuel, Shambrook, Mitch, Xu, Bangyan, Lim, Hui Jing, McWilliam, Hamish E. G., Hill, Andrew F., Edgington-Mitchell, Laura E., Caminschi, Irina, Lahoud, Mireille H., Segura, Elodie, Herold, Marco J., Villadangos, Jose A., Mintern, Justine D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9001657/
https://www.ncbi.nlm.nih.gov/pubmed/35411049
http://dx.doi.org/10.1038/s41467-022-29524-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9001657/
https://www.ncbi.nlm.nih.gov/pubmed/35411049
http://dx.doi.org/10.1038/s41467-022-29524-w

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