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Adenosine inhibits TNFα-induced MMP-3 production in MH7A rheumatoid arthritis synoviocytes via A(2A) receptor signaling

Adenosine causes the anti-inflammatory effect of MTX; however, the contributions of synoviocyte adenosine receptors (AdoRs) are unknown, and matrix metalloproteinase 3 (MMP-3) is released by fibroblast-like synoviocytes in response to inflammatory signaling. To understand the mechanism of the clinic...

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Detalles Bibliográficos
Autores principales:	Konishi, Hiroe, Kanou, Shun-En, Yukimatsu, Rika, Inui, Mizuki, Sato, Motoya, Yamamoto, Naruto, Nakano, Masayoshi, Koshiba, Masahiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9001689/ https://www.ncbi.nlm.nih.gov/pubmed/35410356 http://dx.doi.org/10.1038/s41598-022-10012-6

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