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Carbonized paramagnetic complexes of Mn (II) as contrast agents for precise magnetic resonance imaging of sub-millimeter-sized orthotopic tumors

Paramagnetic complexes containing gadolinium ions have been widely used for magnetic resonance imaging (MRI) in clinic. However, these paramagnetic complexes pose some safety concerns. There is still a demand for the development of stable MRI contrast agents that exhibit higher sensitivity and super...

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Autores principales: Qin, Ruixue, Li, Shi, Qiu, Yuwei, Feng, Yushuo, Liu, Yaqing, Ding, Dandan, Xu, Lihua, Ma, Xiaoqian, Sun, Wenjing, Chen, Hongmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9001709/
https://www.ncbi.nlm.nih.gov/pubmed/35411006
http://dx.doi.org/10.1038/s41467-022-29586-w
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author Qin, Ruixue
Li, Shi
Qiu, Yuwei
Feng, Yushuo
Liu, Yaqing
Ding, Dandan
Xu, Lihua
Ma, Xiaoqian
Sun, Wenjing
Chen, Hongmin
author_facet Qin, Ruixue
Li, Shi
Qiu, Yuwei
Feng, Yushuo
Liu, Yaqing
Ding, Dandan
Xu, Lihua
Ma, Xiaoqian
Sun, Wenjing
Chen, Hongmin
author_sort Qin, Ruixue
collection PubMed
description Paramagnetic complexes containing gadolinium ions have been widely used for magnetic resonance imaging (MRI) in clinic. However, these paramagnetic complexes pose some safety concerns. There is still a demand for the development of stable MRI contrast agents that exhibit higher sensitivity and superior functionality to existing contrast agents. Here, we develop carbonized paramagnetic complexes of manganese (II) (Mn@CCs) to encapsulate Mn(2+) in sealed carbonized shells with superhigh r(1) relaxivity. Compared to the most common clinical contrast agent Magnevist, investigations in vivo demonstrate that the Mn@CCs cross the intact blood-brain barrier of normal health mice with minor metal deposition; preferentially target the glioma tissues distribute homogeneously with high penetration in an intracranial mouse model; delineate clear tumor margins in MRIs of ultrasmall single-nodule brain tumors, and multi-nodular liver tumors. The sensitivity, accuracy and low toxicity offer by Mn@CCs provides new opportunities for early molecular diagnostics and imaging-guided biomedical applications.
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spelling pubmed-90017092022-04-27 Carbonized paramagnetic complexes of Mn (II) as contrast agents for precise magnetic resonance imaging of sub-millimeter-sized orthotopic tumors Qin, Ruixue Li, Shi Qiu, Yuwei Feng, Yushuo Liu, Yaqing Ding, Dandan Xu, Lihua Ma, Xiaoqian Sun, Wenjing Chen, Hongmin Nat Commun Article Paramagnetic complexes containing gadolinium ions have been widely used for magnetic resonance imaging (MRI) in clinic. However, these paramagnetic complexes pose some safety concerns. There is still a demand for the development of stable MRI contrast agents that exhibit higher sensitivity and superior functionality to existing contrast agents. Here, we develop carbonized paramagnetic complexes of manganese (II) (Mn@CCs) to encapsulate Mn(2+) in sealed carbonized shells with superhigh r(1) relaxivity. Compared to the most common clinical contrast agent Magnevist, investigations in vivo demonstrate that the Mn@CCs cross the intact blood-brain barrier of normal health mice with minor metal deposition; preferentially target the glioma tissues distribute homogeneously with high penetration in an intracranial mouse model; delineate clear tumor margins in MRIs of ultrasmall single-nodule brain tumors, and multi-nodular liver tumors. The sensitivity, accuracy and low toxicity offer by Mn@CCs provides new opportunities for early molecular diagnostics and imaging-guided biomedical applications. Nature Publishing Group UK 2022-04-11 /pmc/articles/PMC9001709/ /pubmed/35411006 http://dx.doi.org/10.1038/s41467-022-29586-w Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Qin, Ruixue
Li, Shi
Qiu, Yuwei
Feng, Yushuo
Liu, Yaqing
Ding, Dandan
Xu, Lihua
Ma, Xiaoqian
Sun, Wenjing
Chen, Hongmin
Carbonized paramagnetic complexes of Mn (II) as contrast agents for precise magnetic resonance imaging of sub-millimeter-sized orthotopic tumors
title Carbonized paramagnetic complexes of Mn (II) as contrast agents for precise magnetic resonance imaging of sub-millimeter-sized orthotopic tumors
title_full Carbonized paramagnetic complexes of Mn (II) as contrast agents for precise magnetic resonance imaging of sub-millimeter-sized orthotopic tumors
title_fullStr Carbonized paramagnetic complexes of Mn (II) as contrast agents for precise magnetic resonance imaging of sub-millimeter-sized orthotopic tumors
title_full_unstemmed Carbonized paramagnetic complexes of Mn (II) as contrast agents for precise magnetic resonance imaging of sub-millimeter-sized orthotopic tumors
title_short Carbonized paramagnetic complexes of Mn (II) as contrast agents for precise magnetic resonance imaging of sub-millimeter-sized orthotopic tumors
title_sort carbonized paramagnetic complexes of mn (ii) as contrast agents for precise magnetic resonance imaging of sub-millimeter-sized orthotopic tumors
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9001709/
https://www.ncbi.nlm.nih.gov/pubmed/35411006
http://dx.doi.org/10.1038/s41467-022-29586-w
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