Multiomics implicate gut microbiota in altered lipid and energy metabolism in Parkinson’s disease

We aimed to investigate the link between serum metabolites, gut bacterial community composition, and clinical variables in Parkinson’s disease (PD) and healthy control subjects (HC). A total of 124 subjects were part of the study (63 PD patients and 61 HC subjects). 139 metabolite features were foun...

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Detalles Bibliográficos
Autores principales: Pereira, Pedro A. B., Trivedi, Drupad K., Silverman, Justin, Duru, Ilhan Cem, Paulin, Lars, Auvinen, Petri, Scheperjans, Filip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9001728/
https://www.ncbi.nlm.nih.gov/pubmed/35411052
http://dx.doi.org/10.1038/s41531-022-00300-3
Descripción
Sumario:We aimed to investigate the link between serum metabolites, gut bacterial community composition, and clinical variables in Parkinson’s disease (PD) and healthy control subjects (HC). A total of 124 subjects were part of the study (63 PD patients and 61 HC subjects). 139 metabolite features were found to be predictive between the PD and Control groups. No associations were found between metabolite features and within-PD clinical variables. The results suggest alterations in serum metabolite profiles in PD, and the results of correlation analysis between metabolite features and microbiota suggest that several bacterial taxa are associated with altered lipid and energy metabolism in PD.

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