Multiomics implicate gut microbiota in altered lipid and energy metabolism in Parkinson’s disease

We aimed to investigate the link between serum metabolites, gut bacterial community composition, and clinical variables in Parkinson’s disease (PD) and healthy control subjects (HC). A total of 124 subjects were part of the study (63 PD patients and 61 HC subjects). 139 metabolite features were foun...

Descripción completa

Detalles Bibliográficos
Autores principales: Pereira, Pedro A. B., Trivedi, Drupad K., Silverman, Justin, Duru, Ilhan Cem, Paulin, Lars, Auvinen, Petri, Scheperjans, Filip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9001728/
https://www.ncbi.nlm.nih.gov/pubmed/35411052
http://dx.doi.org/10.1038/s41531-022-00300-3
_version_ 1784685740475547648
author Pereira, Pedro A. B.
Trivedi, Drupad K.
Silverman, Justin
Duru, Ilhan Cem
Paulin, Lars
Auvinen, Petri
Scheperjans, Filip
author_facet Pereira, Pedro A. B.
Trivedi, Drupad K.
Silverman, Justin
Duru, Ilhan Cem
Paulin, Lars
Auvinen, Petri
Scheperjans, Filip
author_sort Pereira, Pedro A. B.
collection PubMed
description We aimed to investigate the link between serum metabolites, gut bacterial community composition, and clinical variables in Parkinson’s disease (PD) and healthy control subjects (HC). A total of 124 subjects were part of the study (63 PD patients and 61 HC subjects). 139 metabolite features were found to be predictive between the PD and Control groups. No associations were found between metabolite features and within-PD clinical variables. The results suggest alterations in serum metabolite profiles in PD, and the results of correlation analysis between metabolite features and microbiota suggest that several bacterial taxa are associated with altered lipid and energy metabolism in PD.
format Online
Article
Text
id pubmed-9001728
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-90017282022-04-27 Multiomics implicate gut microbiota in altered lipid and energy metabolism in Parkinson’s disease Pereira, Pedro A. B. Trivedi, Drupad K. Silverman, Justin Duru, Ilhan Cem Paulin, Lars Auvinen, Petri Scheperjans, Filip NPJ Parkinsons Dis Article We aimed to investigate the link between serum metabolites, gut bacterial community composition, and clinical variables in Parkinson’s disease (PD) and healthy control subjects (HC). A total of 124 subjects were part of the study (63 PD patients and 61 HC subjects). 139 metabolite features were found to be predictive between the PD and Control groups. No associations were found between metabolite features and within-PD clinical variables. The results suggest alterations in serum metabolite profiles in PD, and the results of correlation analysis between metabolite features and microbiota suggest that several bacterial taxa are associated with altered lipid and energy metabolism in PD. Nature Publishing Group UK 2022-04-11 /pmc/articles/PMC9001728/ /pubmed/35411052 http://dx.doi.org/10.1038/s41531-022-00300-3 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Pereira, Pedro A. B.
Trivedi, Drupad K.
Silverman, Justin
Duru, Ilhan Cem
Paulin, Lars
Auvinen, Petri
Scheperjans, Filip
Multiomics implicate gut microbiota in altered lipid and energy metabolism in Parkinson’s disease
title Multiomics implicate gut microbiota in altered lipid and energy metabolism in Parkinson’s disease
title_full Multiomics implicate gut microbiota in altered lipid and energy metabolism in Parkinson’s disease
title_fullStr Multiomics implicate gut microbiota in altered lipid and energy metabolism in Parkinson’s disease
title_full_unstemmed Multiomics implicate gut microbiota in altered lipid and energy metabolism in Parkinson’s disease
title_short Multiomics implicate gut microbiota in altered lipid and energy metabolism in Parkinson’s disease
title_sort multiomics implicate gut microbiota in altered lipid and energy metabolism in parkinson’s disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9001728/
https://www.ncbi.nlm.nih.gov/pubmed/35411052
http://dx.doi.org/10.1038/s41531-022-00300-3
work_keys_str_mv AT pereirapedroab multiomicsimplicategutmicrobiotainalteredlipidandenergymetabolisminparkinsonsdisease
AT trivedidrupadk multiomicsimplicategutmicrobiotainalteredlipidandenergymetabolisminparkinsonsdisease
AT silvermanjustin multiomicsimplicategutmicrobiotainalteredlipidandenergymetabolisminparkinsonsdisease
AT duruilhancem multiomicsimplicategutmicrobiotainalteredlipidandenergymetabolisminparkinsonsdisease
AT paulinlars multiomicsimplicategutmicrobiotainalteredlipidandenergymetabolisminparkinsonsdisease
AT auvinenpetri multiomicsimplicategutmicrobiotainalteredlipidandenergymetabolisminparkinsonsdisease
AT scheperjansfilip multiomicsimplicategutmicrobiotainalteredlipidandenergymetabolisminparkinsonsdisease

Ejemplares similares