A selectivity filter mutation provides insights into gating regulation of a K(+) channel

G-protein coupled inwardly rectifying potassium (GIRK) channels are key players in inhibitory neurotransmission in heart and brain. We conducted molecular dynamics simulations to investigate the effect of a selectivity filter (SF) mutation, G154S, on GIRK2 structure and function. We observe mutation...

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Detalles Bibliográficos
Autores principales: Friesacher, Theres, Reddy, Haritha P., Bernsteiner, Harald, Carlo Combista, J., Shalomov, Boris, Bera, Amal K., Zangerl-Plessl, Eva-Maria, Dascal, Nathan, Stary-Weinzinger, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9001731/
https://www.ncbi.nlm.nih.gov/pubmed/35411015
http://dx.doi.org/10.1038/s42003-022-03303-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9001731/
https://www.ncbi.nlm.nih.gov/pubmed/35411015
http://dx.doi.org/10.1038/s42003-022-03303-1

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