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Insights into the inhibition of type I-F CRISPR-Cas system by a multifunctional anti-CRISPR protein AcrIF24

CRISPR-Cas systems are prokaryotic adaptive immune systems and phages use anti-CRISPR proteins (Acrs) to counteract these systems. Here, we report the structures of AcrIF24 and its complex with the crRNA-guided surveillance (Csy) complex. The HTH motif of AcrIF24 can bind the Acr promoter region and...

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Detalles Bibliográficos
Autores principales:	Yang, Lingguang, Zhang, Laixing, Yin, Peipei, Ding, Hao, Xiao, Yu, Zeng, Jianwei, Wang, Wenhe, Zhou, Huan, Wang, Qisheng, Zhang, Yi, Chen, Zeliang, Yang, Maojun, Feng, Yue
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9001735/ https://www.ncbi.nlm.nih.gov/pubmed/35411005 http://dx.doi.org/10.1038/s41467-022-29581-1

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