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Predictive Factors for Early-Onset Seizures in Patients With Cerebral Venous Sinus Thrombosis

Seizures are reported to be important factors contributing to poor prognosis in patients with cerebral venous sinus thrombosis (CVST). However, the predictive factors for concurrent early onset seizures in patients with CVST remain unclear. To identify the predictive factors of early seizures in pat...

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Autores principales: Mu, Shuwen, Li, Jun, Lin, Kunzhe, Fang, Yi, Lin, Feng, Li, Ziqi, Xu, Yongjun, Wang, Shousen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9001912/
https://www.ncbi.nlm.nih.gov/pubmed/35422753
http://dx.doi.org/10.3389/fneur.2022.842807
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author Mu, Shuwen
Li, Jun
Lin, Kunzhe
Fang, Yi
Lin, Feng
Li, Ziqi
Xu, Yongjun
Wang, Shousen
author_facet Mu, Shuwen
Li, Jun
Lin, Kunzhe
Fang, Yi
Lin, Feng
Li, Ziqi
Xu, Yongjun
Wang, Shousen
author_sort Mu, Shuwen
collection PubMed
description Seizures are reported to be important factors contributing to poor prognosis in patients with cerebral venous sinus thrombosis (CVST). However, the predictive factors for concurrent early onset seizures in patients with CVST remain unclear. To identify the predictive factors of early seizures in patients with CVST, this study retrospectively evaluated the clinical data of patients diagnosed with CVST at two centers from January 2011 to December 2020 and analyzed the relationship between admission characteristics and early onset seizures. A total of 112 CVST patients (63 men and 49 women; mean age 39.82 ± 15.70 years) were enrolled in this study, of whom 34 (30.36%) had seizures. For patients with seizures, cerebral hemorrhage, cortical vein thrombosis, anterior superior sagittal sinus (SSS) thrombosis, middle SSS thrombosis, CVST score, modified Rankin Scale, National Institute of Health Stroke Scale (NIHSS) score, neutrophil percentage, and D-dimer level were more severe than those without seizures. Logistic regression analysis showed that cerebral hemorrhage (P = 0.002), anterior SSS thrombosis (P = 0.003), NIHSS score ≥5 (P = 0.003), and D-dimer ≥0.88 mg/L (P = 0.004) were all significant predictive factors of early-onset seizures in CVST patients. Combining the four factors further improved the predictive capability with an area under the curve of 0.871 (95% confidence interval = 0.803–0.939). Further large-scale prospective studies are required to confirm these findings.
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spelling pubmed-90019122022-04-13 Predictive Factors for Early-Onset Seizures in Patients With Cerebral Venous Sinus Thrombosis Mu, Shuwen Li, Jun Lin, Kunzhe Fang, Yi Lin, Feng Li, Ziqi Xu, Yongjun Wang, Shousen Front Neurol Neurology Seizures are reported to be important factors contributing to poor prognosis in patients with cerebral venous sinus thrombosis (CVST). However, the predictive factors for concurrent early onset seizures in patients with CVST remain unclear. To identify the predictive factors of early seizures in patients with CVST, this study retrospectively evaluated the clinical data of patients diagnosed with CVST at two centers from January 2011 to December 2020 and analyzed the relationship between admission characteristics and early onset seizures. A total of 112 CVST patients (63 men and 49 women; mean age 39.82 ± 15.70 years) were enrolled in this study, of whom 34 (30.36%) had seizures. For patients with seizures, cerebral hemorrhage, cortical vein thrombosis, anterior superior sagittal sinus (SSS) thrombosis, middle SSS thrombosis, CVST score, modified Rankin Scale, National Institute of Health Stroke Scale (NIHSS) score, neutrophil percentage, and D-dimer level were more severe than those without seizures. Logistic regression analysis showed that cerebral hemorrhage (P = 0.002), anterior SSS thrombosis (P = 0.003), NIHSS score ≥5 (P = 0.003), and D-dimer ≥0.88 mg/L (P = 0.004) were all significant predictive factors of early-onset seizures in CVST patients. Combining the four factors further improved the predictive capability with an area under the curve of 0.871 (95% confidence interval = 0.803–0.939). Further large-scale prospective studies are required to confirm these findings. Frontiers Media S.A. 2022-03-29 /pmc/articles/PMC9001912/ /pubmed/35422753 http://dx.doi.org/10.3389/fneur.2022.842807 Text en Copyright © 2022 Mu, Li, Lin, Fang, Lin, Li, Xu and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Mu, Shuwen
Li, Jun
Lin, Kunzhe
Fang, Yi
Lin, Feng
Li, Ziqi
Xu, Yongjun
Wang, Shousen
Predictive Factors for Early-Onset Seizures in Patients With Cerebral Venous Sinus Thrombosis
title Predictive Factors for Early-Onset Seizures in Patients With Cerebral Venous Sinus Thrombosis
title_full Predictive Factors for Early-Onset Seizures in Patients With Cerebral Venous Sinus Thrombosis
title_fullStr Predictive Factors for Early-Onset Seizures in Patients With Cerebral Venous Sinus Thrombosis
title_full_unstemmed Predictive Factors for Early-Onset Seizures in Patients With Cerebral Venous Sinus Thrombosis
title_short Predictive Factors for Early-Onset Seizures in Patients With Cerebral Venous Sinus Thrombosis
title_sort predictive factors for early-onset seizures in patients with cerebral venous sinus thrombosis
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9001912/
https://www.ncbi.nlm.nih.gov/pubmed/35422753
http://dx.doi.org/10.3389/fneur.2022.842807
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