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Hypothetical protein predicted to be tumor suppressor: a protein functional analysis

Litorilituus sediminis is a Gram-negative, aerobic, novel bacterium under the family of Colwelliaceae, has a stunning hypothetical protein containing domain called von Hippel-Lindau that has significant tumor suppressor activity. Therefore, this study was designed to elucidate the structure and func...

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Autores principales: Kader, Md. Abdul, Ahammed, Akash, Khan, Md. Sharif, Ashik, Sheikh Abdullah Al, Islam, Md. Shariful, Hossain, Mohammad Uzzal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korea Genome Organization 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9002001/
https://www.ncbi.nlm.nih.gov/pubmed/35399005
http://dx.doi.org/10.5808/gi.21073
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author Kader, Md. Abdul
Ahammed, Akash
Khan, Md. Sharif
Ashik, Sheikh Abdullah Al
Islam, Md. Shariful
Hossain, Mohammad Uzzal
author_facet Kader, Md. Abdul
Ahammed, Akash
Khan, Md. Sharif
Ashik, Sheikh Abdullah Al
Islam, Md. Shariful
Hossain, Mohammad Uzzal
author_sort Kader, Md. Abdul
collection PubMed
description Litorilituus sediminis is a Gram-negative, aerobic, novel bacterium under the family of Colwelliaceae, has a stunning hypothetical protein containing domain called von Hippel-Lindau that has significant tumor suppressor activity. Therefore, this study was designed to elucidate the structure and function of the biologically important hypothetical protein EMK97_00595 (QBG34344.1) using several bioinformatics tools. The functional annotation exposed that the hypothetical protein is an extracellular secretory soluble signal peptide and contains the von Hippel-Lindau (VHL; VHL beta) domain that has a significant role in tumor suppression. This domain is conserved throughout evolution, as its homologs are available in various types of the organism like mammals, insects, and nematode. The gene product of VHL has a critical regulatory activity in the ubiquitous oxygen-sensing pathway. This domain has a significant role in inhibiting cell proliferation, angiogenesis progression, kidney cancer, breast cancer, and colon cancer. At last, the current study depicts that the annotated hypothetical protein is linked with tumor suppressor activity which might be of great interest to future research in the higher organism.
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spelling pubmed-90020012022-04-21 Hypothetical protein predicted to be tumor suppressor: a protein functional analysis Kader, Md. Abdul Ahammed, Akash Khan, Md. Sharif Ashik, Sheikh Abdullah Al Islam, Md. Shariful Hossain, Mohammad Uzzal Genomics Inform Original Article Litorilituus sediminis is a Gram-negative, aerobic, novel bacterium under the family of Colwelliaceae, has a stunning hypothetical protein containing domain called von Hippel-Lindau that has significant tumor suppressor activity. Therefore, this study was designed to elucidate the structure and function of the biologically important hypothetical protein EMK97_00595 (QBG34344.1) using several bioinformatics tools. The functional annotation exposed that the hypothetical protein is an extracellular secretory soluble signal peptide and contains the von Hippel-Lindau (VHL; VHL beta) domain that has a significant role in tumor suppression. This domain is conserved throughout evolution, as its homologs are available in various types of the organism like mammals, insects, and nematode. The gene product of VHL has a critical regulatory activity in the ubiquitous oxygen-sensing pathway. This domain has a significant role in inhibiting cell proliferation, angiogenesis progression, kidney cancer, breast cancer, and colon cancer. At last, the current study depicts that the annotated hypothetical protein is linked with tumor suppressor activity which might be of great interest to future research in the higher organism. Korea Genome Organization 2022-03-31 /pmc/articles/PMC9002001/ /pubmed/35399005 http://dx.doi.org/10.5808/gi.21073 Text en (c) 2022, Korea Genome Organization https://creativecommons.org/licenses/by/4.0/(CC) This is an open-access article distributed under the terms of the Creative Commons Attribution license(https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kader, Md. Abdul
Ahammed, Akash
Khan, Md. Sharif
Ashik, Sheikh Abdullah Al
Islam, Md. Shariful
Hossain, Mohammad Uzzal
Hypothetical protein predicted to be tumor suppressor: a protein functional analysis
title Hypothetical protein predicted to be tumor suppressor: a protein functional analysis
title_full Hypothetical protein predicted to be tumor suppressor: a protein functional analysis
title_fullStr Hypothetical protein predicted to be tumor suppressor: a protein functional analysis
title_full_unstemmed Hypothetical protein predicted to be tumor suppressor: a protein functional analysis
title_short Hypothetical protein predicted to be tumor suppressor: a protein functional analysis
title_sort hypothetical protein predicted to be tumor suppressor: a protein functional analysis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9002001/
https://www.ncbi.nlm.nih.gov/pubmed/35399005
http://dx.doi.org/10.5808/gi.21073
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