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Translational Control of COVID-19 and Its Therapeutic Implication
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of COVID-19, which has broken out worldwide for more than two years. However, due to limited treatment, new cases of infection are still rising. Therefore, there is an urgent need to understand the basic molecula...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9002053/ https://www.ncbi.nlm.nih.gov/pubmed/35422818 http://dx.doi.org/10.3389/fimmu.2022.857490 |
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author | Zhang, Dejiu Zhu, Lei Wang, Yin Li, Peifeng Gao, Yanyan |
author_facet | Zhang, Dejiu Zhu, Lei Wang, Yin Li, Peifeng Gao, Yanyan |
author_sort | Zhang, Dejiu |
collection | PubMed |
description | The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of COVID-19, which has broken out worldwide for more than two years. However, due to limited treatment, new cases of infection are still rising. Therefore, there is an urgent need to understand the basic molecular biology of SARS-CoV-2 to control this virus. SARS-CoV-2 replication and spread depend on the recruitment of host ribosomes to translate viral messenger RNA (mRNA). To ensure the translation of their own mRNAs, the SARS-CoV-2 has developed multiple strategies to globally inhibit the translation of host mRNAs and block the cellular innate immune response. This review provides a comprehensive picture of recent advancements in our understanding of the molecular basis and complexity of SARS-CoV-2 protein translation. Specifically, we summarize how this viral infection inhibits host mRNA translation to better utilize translation elements for translation of its own mRNA. Finally, we discuss the potential of translational components as targets for therapeutic interventions. |
format | Online Article Text |
id | pubmed-9002053 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-90020532022-04-13 Translational Control of COVID-19 and Its Therapeutic Implication Zhang, Dejiu Zhu, Lei Wang, Yin Li, Peifeng Gao, Yanyan Front Immunol Immunology The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of COVID-19, which has broken out worldwide for more than two years. However, due to limited treatment, new cases of infection are still rising. Therefore, there is an urgent need to understand the basic molecular biology of SARS-CoV-2 to control this virus. SARS-CoV-2 replication and spread depend on the recruitment of host ribosomes to translate viral messenger RNA (mRNA). To ensure the translation of their own mRNAs, the SARS-CoV-2 has developed multiple strategies to globally inhibit the translation of host mRNAs and block the cellular innate immune response. This review provides a comprehensive picture of recent advancements in our understanding of the molecular basis and complexity of SARS-CoV-2 protein translation. Specifically, we summarize how this viral infection inhibits host mRNA translation to better utilize translation elements for translation of its own mRNA. Finally, we discuss the potential of translational components as targets for therapeutic interventions. Frontiers Media S.A. 2022-03-29 /pmc/articles/PMC9002053/ /pubmed/35422818 http://dx.doi.org/10.3389/fimmu.2022.857490 Text en Copyright © 2022 Zhang, Zhu, Wang, Li and Gao https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Zhang, Dejiu Zhu, Lei Wang, Yin Li, Peifeng Gao, Yanyan Translational Control of COVID-19 and Its Therapeutic Implication |
title | Translational Control of COVID-19 and Its Therapeutic Implication |
title_full | Translational Control of COVID-19 and Its Therapeutic Implication |
title_fullStr | Translational Control of COVID-19 and Its Therapeutic Implication |
title_full_unstemmed | Translational Control of COVID-19 and Its Therapeutic Implication |
title_short | Translational Control of COVID-19 and Its Therapeutic Implication |
title_sort | translational control of covid-19 and its therapeutic implication |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9002053/ https://www.ncbi.nlm.nih.gov/pubmed/35422818 http://dx.doi.org/10.3389/fimmu.2022.857490 |
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