Bruton’s Tyrosine Kinase Supports Gut Mucosal Immunity and Commensal Microbiome Recognition in Autoimmune Arthritis

Bruton’s tyrosine kinase (Btk) deficiency preferentially eliminates autoreactive B cells while sparing normal humoral responses, but has not been studied in mucosal immunity. Commensal microbes and intact BTK signaling have been independently shown to be essential for arthritis development in K/BxN...

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Detalles Bibliográficos
Autores principales: Bonami, Rachel H., Thurman, Christina E., Verma, Sonam, Westlake, Camille S., Nyhoff, Lindsay E., Barron, Bridgette B., Reboldi, Andrea, Kendall, Peggy L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9002138/
https://www.ncbi.nlm.nih.gov/pubmed/35422819
http://dx.doi.org/10.3389/fimmu.2022.748284

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