Simultaneous determination of clopidogrel, 2-oxo-clopidogrel, and the thiol metabolite of clopidogrel in human plasma by LC-MS/MS

Clopidogrel is a pro-drug which needs two-step metabolism to produce the active thiol metabolite. This study aimed to explore an efficient method to simultaneously determine the plasma clopidogrel, 2-oxo-clopidogrel (2-Oxo-CLP), and the clopidogrel active metabolite (CAM). A high-throughput liquid c...

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Detalles Bibliográficos
Autores principales: Xu, Lei, Li, Ran, Li, Juan, Dong, Zhou, Zong, Jiaxin, Tan, Chuchu, Ye, Zekang, Shi, Lu, Gong, Xiaoxuan, Li, Chunjian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Editorial Department of Journal of Biomedical Research 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9002156/
https://www.ncbi.nlm.nih.gov/pubmed/35387902
http://dx.doi.org/10.7555/JBR.36.20210125

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