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The effectiveness of tamsulosin hydrochloride with terazosin combination therapy for chronic prostatitis Type-III b
OBJECTIVES: To study the therapeutic effects of combined tamsulosin hydrochloride and terazosin treatment for patients with chronic prostatitis Type-III b. METHODS: This study involved 180 patients with chronic prostatitis Type-III b treated between January 2018 and December 2020 conducted at Nanhua...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Professional Medical Publications
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9002402/ https://www.ncbi.nlm.nih.gov/pubmed/35480502 http://dx.doi.org/10.12669/pjms.38.3.4931 |
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author | Duan, Bin Wang, Xinxi |
author_facet | Duan, Bin Wang, Xinxi |
author_sort | Duan, Bin |
collection | PubMed |
description | OBJECTIVES: To study the therapeutic effects of combined tamsulosin hydrochloride and terazosin treatment for patients with chronic prostatitis Type-III b. METHODS: This study involved 180 patients with chronic prostatitis Type-III b treated between January 2018 and December 2020 conducted at Nanhua Hospital Affiliated to Nanhua University. Patients were randomly divided into two equal groups: one receiving oral terazosin hydrochloride tablets only (control group), and one orally receiving both tamsulosin hydrochloride sustained-release tablets and terazosin hydrochloride tablets (observation group). Outcome measurements included symptom scoring, inflammatory cytokine levels, as well as white blood cell and lecithin body counts in the prostatic fluid. RESULTS: After 30 days of treatment, the observation group showed greater treatment effectiveness (86.67% vs. 73.33%, P<0.05). QLS, USS, PS, and NIH-CPSI symptom scores were lower in the observation group than the control group (P<0.05). No differences in adverse event distribution and incidence were noted. EPS IL-2 increased more in the observation group, while PGE-2, MIP-1α, and MIP-2 decreased more in the observation group. WBC levels decreased more in the observation group, while lecithin body levels increased more in the observation group. CONCLUSION: The combination of tamsulosin hydrochloride and terazosin for the treatment of patients with chronic prostatitis Type-III b has a significant effect. This approach reduced patient symptoms, lowered inflammatory biomarkers, and generally improved quality of life. This approach appears to have clinical value worthy of future investigation. |
format | Online Article Text |
id | pubmed-9002402 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Professional Medical Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-90024022022-04-26 The effectiveness of tamsulosin hydrochloride with terazosin combination therapy for chronic prostatitis Type-III b Duan, Bin Wang, Xinxi Pak J Med Sci Original Article OBJECTIVES: To study the therapeutic effects of combined tamsulosin hydrochloride and terazosin treatment for patients with chronic prostatitis Type-III b. METHODS: This study involved 180 patients with chronic prostatitis Type-III b treated between January 2018 and December 2020 conducted at Nanhua Hospital Affiliated to Nanhua University. Patients were randomly divided into two equal groups: one receiving oral terazosin hydrochloride tablets only (control group), and one orally receiving both tamsulosin hydrochloride sustained-release tablets and terazosin hydrochloride tablets (observation group). Outcome measurements included symptom scoring, inflammatory cytokine levels, as well as white blood cell and lecithin body counts in the prostatic fluid. RESULTS: After 30 days of treatment, the observation group showed greater treatment effectiveness (86.67% vs. 73.33%, P<0.05). QLS, USS, PS, and NIH-CPSI symptom scores were lower in the observation group than the control group (P<0.05). No differences in adverse event distribution and incidence were noted. EPS IL-2 increased more in the observation group, while PGE-2, MIP-1α, and MIP-2 decreased more in the observation group. WBC levels decreased more in the observation group, while lecithin body levels increased more in the observation group. CONCLUSION: The combination of tamsulosin hydrochloride and terazosin for the treatment of patients with chronic prostatitis Type-III b has a significant effect. This approach reduced patient symptoms, lowered inflammatory biomarkers, and generally improved quality of life. This approach appears to have clinical value worthy of future investigation. Professional Medical Publications 2022 /pmc/articles/PMC9002402/ /pubmed/35480502 http://dx.doi.org/10.12669/pjms.38.3.4931 Text en Copyright: © Pakistan Journal of Medical Sciences https://creativecommons.org/licenses/by/3.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0 (https://creativecommons.org/licenses/by/3.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Duan, Bin Wang, Xinxi The effectiveness of tamsulosin hydrochloride with terazosin combination therapy for chronic prostatitis Type-III b |
title | The effectiveness of tamsulosin hydrochloride with terazosin combination therapy for chronic prostatitis Type-III b |
title_full | The effectiveness of tamsulosin hydrochloride with terazosin combination therapy for chronic prostatitis Type-III b |
title_fullStr | The effectiveness of tamsulosin hydrochloride with terazosin combination therapy for chronic prostatitis Type-III b |
title_full_unstemmed | The effectiveness of tamsulosin hydrochloride with terazosin combination therapy for chronic prostatitis Type-III b |
title_short | The effectiveness of tamsulosin hydrochloride with terazosin combination therapy for chronic prostatitis Type-III b |
title_sort | effectiveness of tamsulosin hydrochloride with terazosin combination therapy for chronic prostatitis type-iii b |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9002402/ https://www.ncbi.nlm.nih.gov/pubmed/35480502 http://dx.doi.org/10.12669/pjms.38.3.4931 |
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