Cargando…
Effect of Evening Primrose Oil Supplementation on Biochemical Parameters and Nutrition of Patients Treated with Isotretinoin for Acne Vulgaris: A Randomized Double-Blind Trial
Background: Acne vulgaris is one of the most common skin diseases. One of the therapeutic options recommended for severe acne or acne that has not responded to previous therapies is isotretinoin. However, its use may lead to adverse changes in the serum lipid profile and increased levels of transami...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9002552/ https://www.ncbi.nlm.nih.gov/pubmed/35405955 http://dx.doi.org/10.3390/nu14071342 |
_version_ | 1784685918203936768 |
---|---|
author | Kaźmierska, Agnieszka Bolesławska, Izabela Jagielski, Paweł Polańska, Adriana Dańczak-Pazdrowska, Aleksandra Kosewski, Grzegorz Adamski, Zygmunt Przysławski, Juliusz |
author_facet | Kaźmierska, Agnieszka Bolesławska, Izabela Jagielski, Paweł Polańska, Adriana Dańczak-Pazdrowska, Aleksandra Kosewski, Grzegorz Adamski, Zygmunt Przysławski, Juliusz |
author_sort | Kaźmierska, Agnieszka |
collection | PubMed |
description | Background: Acne vulgaris is one of the most common skin diseases. One of the therapeutic options recommended for severe acne or acne that has not responded to previous therapies is isotretinoin. However, its use may lead to adverse changes in the serum lipid profile and increased levels of transaminases. In this study, we evaluated the effect of supplementation with evening primrose oil in acne vulgaris patients treated with isotretinoin on blood lipid parameters and transaminase activity. Methods: Study participants were randomly assigned to two treatments: conventional with isotretinoin (25 patients) and novel with isotretinoin combined with evening primrose oil (4 × 510 mg/day; 25 patients) for 9 months. Results: Compared to isotretinoin treatment, isotretinoin treatment combined with evening primrose oil had a positive effect on TCH concentrations (mean: 198 vs. 161, p < 0.001), LDL (95.9 vs. 60.2, p < 0.001), HDL (51.0 vs. 48.0, p < 0.001), TG (114 vs. 95.0, p < 0.001), ALT (24.0 vs. 22.0, p < 0.001), and AST (28.0 vs. 22.0, p < 0.001), but had no effect on the energy and ingredient content of the diets (p > 0.05) after treatment. Conclusion: Evening primrose oil was found to have beneficial effects on lipid profiles and transaminase activity during isotretinoin treatment. However, longer studies are needed to make more reliable decisions regarding the use of evening primrose oil and its safety in clinical practice. The evening primrose oil treatment group also showed a reduction in dietary energy due to a reduction in dietary protein and carbohydrates. |
format | Online Article Text |
id | pubmed-9002552 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-90025522022-04-13 Effect of Evening Primrose Oil Supplementation on Biochemical Parameters and Nutrition of Patients Treated with Isotretinoin for Acne Vulgaris: A Randomized Double-Blind Trial Kaźmierska, Agnieszka Bolesławska, Izabela Jagielski, Paweł Polańska, Adriana Dańczak-Pazdrowska, Aleksandra Kosewski, Grzegorz Adamski, Zygmunt Przysławski, Juliusz Nutrients Communication Background: Acne vulgaris is one of the most common skin diseases. One of the therapeutic options recommended for severe acne or acne that has not responded to previous therapies is isotretinoin. However, its use may lead to adverse changes in the serum lipid profile and increased levels of transaminases. In this study, we evaluated the effect of supplementation with evening primrose oil in acne vulgaris patients treated with isotretinoin on blood lipid parameters and transaminase activity. Methods: Study participants were randomly assigned to two treatments: conventional with isotretinoin (25 patients) and novel with isotretinoin combined with evening primrose oil (4 × 510 mg/day; 25 patients) for 9 months. Results: Compared to isotretinoin treatment, isotretinoin treatment combined with evening primrose oil had a positive effect on TCH concentrations (mean: 198 vs. 161, p < 0.001), LDL (95.9 vs. 60.2, p < 0.001), HDL (51.0 vs. 48.0, p < 0.001), TG (114 vs. 95.0, p < 0.001), ALT (24.0 vs. 22.0, p < 0.001), and AST (28.0 vs. 22.0, p < 0.001), but had no effect on the energy and ingredient content of the diets (p > 0.05) after treatment. Conclusion: Evening primrose oil was found to have beneficial effects on lipid profiles and transaminase activity during isotretinoin treatment. However, longer studies are needed to make more reliable decisions regarding the use of evening primrose oil and its safety in clinical practice. The evening primrose oil treatment group also showed a reduction in dietary energy due to a reduction in dietary protein and carbohydrates. MDPI 2022-03-23 /pmc/articles/PMC9002552/ /pubmed/35405955 http://dx.doi.org/10.3390/nu14071342 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Communication Kaźmierska, Agnieszka Bolesławska, Izabela Jagielski, Paweł Polańska, Adriana Dańczak-Pazdrowska, Aleksandra Kosewski, Grzegorz Adamski, Zygmunt Przysławski, Juliusz Effect of Evening Primrose Oil Supplementation on Biochemical Parameters and Nutrition of Patients Treated with Isotretinoin for Acne Vulgaris: A Randomized Double-Blind Trial |
title | Effect of Evening Primrose Oil Supplementation on Biochemical Parameters and Nutrition of Patients Treated with Isotretinoin for Acne Vulgaris: A Randomized Double-Blind Trial |
title_full | Effect of Evening Primrose Oil Supplementation on Biochemical Parameters and Nutrition of Patients Treated with Isotretinoin for Acne Vulgaris: A Randomized Double-Blind Trial |
title_fullStr | Effect of Evening Primrose Oil Supplementation on Biochemical Parameters and Nutrition of Patients Treated with Isotretinoin for Acne Vulgaris: A Randomized Double-Blind Trial |
title_full_unstemmed | Effect of Evening Primrose Oil Supplementation on Biochemical Parameters and Nutrition of Patients Treated with Isotretinoin for Acne Vulgaris: A Randomized Double-Blind Trial |
title_short | Effect of Evening Primrose Oil Supplementation on Biochemical Parameters and Nutrition of Patients Treated with Isotretinoin for Acne Vulgaris: A Randomized Double-Blind Trial |
title_sort | effect of evening primrose oil supplementation on biochemical parameters and nutrition of patients treated with isotretinoin for acne vulgaris: a randomized double-blind trial |
topic | Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9002552/ https://www.ncbi.nlm.nih.gov/pubmed/35405955 http://dx.doi.org/10.3390/nu14071342 |
work_keys_str_mv | AT kazmierskaagnieszka effectofeveningprimroseoilsupplementationonbiochemicalparametersandnutritionofpatientstreatedwithisotretinoinforacnevulgarisarandomizeddoubleblindtrial AT bolesławskaizabela effectofeveningprimroseoilsupplementationonbiochemicalparametersandnutritionofpatientstreatedwithisotretinoinforacnevulgarisarandomizeddoubleblindtrial AT jagielskipaweł effectofeveningprimroseoilsupplementationonbiochemicalparametersandnutritionofpatientstreatedwithisotretinoinforacnevulgarisarandomizeddoubleblindtrial AT polanskaadriana effectofeveningprimroseoilsupplementationonbiochemicalparametersandnutritionofpatientstreatedwithisotretinoinforacnevulgarisarandomizeddoubleblindtrial AT danczakpazdrowskaaleksandra effectofeveningprimroseoilsupplementationonbiochemicalparametersandnutritionofpatientstreatedwithisotretinoinforacnevulgarisarandomizeddoubleblindtrial AT kosewskigrzegorz effectofeveningprimroseoilsupplementationonbiochemicalparametersandnutritionofpatientstreatedwithisotretinoinforacnevulgarisarandomizeddoubleblindtrial AT adamskizygmunt effectofeveningprimroseoilsupplementationonbiochemicalparametersandnutritionofpatientstreatedwithisotretinoinforacnevulgarisarandomizeddoubleblindtrial AT przysławskijuliusz effectofeveningprimroseoilsupplementationonbiochemicalparametersandnutritionofpatientstreatedwithisotretinoinforacnevulgarisarandomizeddoubleblindtrial |