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Circulating Human Serum Metabolites Derived from the Intake of a Saffron Extract (Safr’Inside(TM)) Protect Neurons from Oxidative Stress: Consideration for Depressive Disorders

Increases in oxidative stress have been reported to play a central role in the vulnerability to depression, and antidepressant drugs may reduce increased oxidative stress in patients. Among the plants exerting anti-inflammatory and anti-oxidant properties, saffron, a spice derived from the flower of...

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Autores principales: Wauquier, Fabien, Boutin-Wittrant, Line, Pourtau, Line, Gaudout, David, Moras, Benjamin, Vignault, Adeline, Monchaux De Oliveira, Camille, Gabaston, Julien, Vaysse, Carole, Bertrand, Karène, Abrous, Hélène, Capuron, Lucile, Castanon, Nathalie, Vauzour, David, Roux, Véronique, Macian, Nicolas, Pickering, Gisèle, Wittrant, Yohann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9002571/
https://www.ncbi.nlm.nih.gov/pubmed/35406124
http://dx.doi.org/10.3390/nu14071511
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author Wauquier, Fabien
Boutin-Wittrant, Line
Pourtau, Line
Gaudout, David
Moras, Benjamin
Vignault, Adeline
Monchaux De Oliveira, Camille
Gabaston, Julien
Vaysse, Carole
Bertrand, Karène
Abrous, Hélène
Capuron, Lucile
Castanon, Nathalie
Vauzour, David
Roux, Véronique
Macian, Nicolas
Pickering, Gisèle
Wittrant, Yohann
author_facet Wauquier, Fabien
Boutin-Wittrant, Line
Pourtau, Line
Gaudout, David
Moras, Benjamin
Vignault, Adeline
Monchaux De Oliveira, Camille
Gabaston, Julien
Vaysse, Carole
Bertrand, Karène
Abrous, Hélène
Capuron, Lucile
Castanon, Nathalie
Vauzour, David
Roux, Véronique
Macian, Nicolas
Pickering, Gisèle
Wittrant, Yohann
author_sort Wauquier, Fabien
collection PubMed
description Increases in oxidative stress have been reported to play a central role in the vulnerability to depression, and antidepressant drugs may reduce increased oxidative stress in patients. Among the plants exerting anti-inflammatory and anti-oxidant properties, saffron, a spice derived from the flower of Crocus sativus, is also known for its positive effects on depression, potentially through its SSRI-like properties. However, the molecular mechanisms underlying these effects and their health benefits for humans are currently unclear. Using an original ex vivo clinical approach, we demonstrated for the first time that the circulating human metabolites produced following saffron intake (Safr’Inside(TM)) protect human neurons from oxidative-stress-induced neurotoxicity by preserving cell viability and increasing BNDF production. In particular, the metabolites significantly stimulated both dopamine and serotonin release. In addition, the saffron’s metabolites were also able to protect serotonergic tone by inhibiting the expression of the serotonin transporter SERT and down-regulating serotonin metabolism. Altogether, these data provide new biochemical insights into the mechanisms underlying the beneficial impact of saffron on neuronal viability and activity in humans, in the context of oxidative stress related to depression.
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spelling pubmed-90025712022-04-13 Circulating Human Serum Metabolites Derived from the Intake of a Saffron Extract (Safr’Inside(TM)) Protect Neurons from Oxidative Stress: Consideration for Depressive Disorders Wauquier, Fabien Boutin-Wittrant, Line Pourtau, Line Gaudout, David Moras, Benjamin Vignault, Adeline Monchaux De Oliveira, Camille Gabaston, Julien Vaysse, Carole Bertrand, Karène Abrous, Hélène Capuron, Lucile Castanon, Nathalie Vauzour, David Roux, Véronique Macian, Nicolas Pickering, Gisèle Wittrant, Yohann Nutrients Article Increases in oxidative stress have been reported to play a central role in the vulnerability to depression, and antidepressant drugs may reduce increased oxidative stress in patients. Among the plants exerting anti-inflammatory and anti-oxidant properties, saffron, a spice derived from the flower of Crocus sativus, is also known for its positive effects on depression, potentially through its SSRI-like properties. However, the molecular mechanisms underlying these effects and their health benefits for humans are currently unclear. Using an original ex vivo clinical approach, we demonstrated for the first time that the circulating human metabolites produced following saffron intake (Safr’Inside(TM)) protect human neurons from oxidative-stress-induced neurotoxicity by preserving cell viability and increasing BNDF production. In particular, the metabolites significantly stimulated both dopamine and serotonin release. In addition, the saffron’s metabolites were also able to protect serotonergic tone by inhibiting the expression of the serotonin transporter SERT and down-regulating serotonin metabolism. Altogether, these data provide new biochemical insights into the mechanisms underlying the beneficial impact of saffron on neuronal viability and activity in humans, in the context of oxidative stress related to depression. MDPI 2022-04-05 /pmc/articles/PMC9002571/ /pubmed/35406124 http://dx.doi.org/10.3390/nu14071511 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wauquier, Fabien
Boutin-Wittrant, Line
Pourtau, Line
Gaudout, David
Moras, Benjamin
Vignault, Adeline
Monchaux De Oliveira, Camille
Gabaston, Julien
Vaysse, Carole
Bertrand, Karène
Abrous, Hélène
Capuron, Lucile
Castanon, Nathalie
Vauzour, David
Roux, Véronique
Macian, Nicolas
Pickering, Gisèle
Wittrant, Yohann
Circulating Human Serum Metabolites Derived from the Intake of a Saffron Extract (Safr’Inside(TM)) Protect Neurons from Oxidative Stress: Consideration for Depressive Disorders
title Circulating Human Serum Metabolites Derived from the Intake of a Saffron Extract (Safr’Inside(TM)) Protect Neurons from Oxidative Stress: Consideration for Depressive Disorders
title_full Circulating Human Serum Metabolites Derived from the Intake of a Saffron Extract (Safr’Inside(TM)) Protect Neurons from Oxidative Stress: Consideration for Depressive Disorders
title_fullStr Circulating Human Serum Metabolites Derived from the Intake of a Saffron Extract (Safr’Inside(TM)) Protect Neurons from Oxidative Stress: Consideration for Depressive Disorders
title_full_unstemmed Circulating Human Serum Metabolites Derived from the Intake of a Saffron Extract (Safr’Inside(TM)) Protect Neurons from Oxidative Stress: Consideration for Depressive Disorders
title_short Circulating Human Serum Metabolites Derived from the Intake of a Saffron Extract (Safr’Inside(TM)) Protect Neurons from Oxidative Stress: Consideration for Depressive Disorders
title_sort circulating human serum metabolites derived from the intake of a saffron extract (safr’inside(tm)) protect neurons from oxidative stress: consideration for depressive disorders
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9002571/
https://www.ncbi.nlm.nih.gov/pubmed/35406124
http://dx.doi.org/10.3390/nu14071511
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