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Circulating Human Serum Metabolites Derived from the Intake of a Saffron Extract (Safr’Inside(TM)) Protect Neurons from Oxidative Stress: Consideration for Depressive Disorders
Increases in oxidative stress have been reported to play a central role in the vulnerability to depression, and antidepressant drugs may reduce increased oxidative stress in patients. Among the plants exerting anti-inflammatory and anti-oxidant properties, saffron, a spice derived from the flower of...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9002571/ https://www.ncbi.nlm.nih.gov/pubmed/35406124 http://dx.doi.org/10.3390/nu14071511 |
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author | Wauquier, Fabien Boutin-Wittrant, Line Pourtau, Line Gaudout, David Moras, Benjamin Vignault, Adeline Monchaux De Oliveira, Camille Gabaston, Julien Vaysse, Carole Bertrand, Karène Abrous, Hélène Capuron, Lucile Castanon, Nathalie Vauzour, David Roux, Véronique Macian, Nicolas Pickering, Gisèle Wittrant, Yohann |
author_facet | Wauquier, Fabien Boutin-Wittrant, Line Pourtau, Line Gaudout, David Moras, Benjamin Vignault, Adeline Monchaux De Oliveira, Camille Gabaston, Julien Vaysse, Carole Bertrand, Karène Abrous, Hélène Capuron, Lucile Castanon, Nathalie Vauzour, David Roux, Véronique Macian, Nicolas Pickering, Gisèle Wittrant, Yohann |
author_sort | Wauquier, Fabien |
collection | PubMed |
description | Increases in oxidative stress have been reported to play a central role in the vulnerability to depression, and antidepressant drugs may reduce increased oxidative stress in patients. Among the plants exerting anti-inflammatory and anti-oxidant properties, saffron, a spice derived from the flower of Crocus sativus, is also known for its positive effects on depression, potentially through its SSRI-like properties. However, the molecular mechanisms underlying these effects and their health benefits for humans are currently unclear. Using an original ex vivo clinical approach, we demonstrated for the first time that the circulating human metabolites produced following saffron intake (Safr’Inside(TM)) protect human neurons from oxidative-stress-induced neurotoxicity by preserving cell viability and increasing BNDF production. In particular, the metabolites significantly stimulated both dopamine and serotonin release. In addition, the saffron’s metabolites were also able to protect serotonergic tone by inhibiting the expression of the serotonin transporter SERT and down-regulating serotonin metabolism. Altogether, these data provide new biochemical insights into the mechanisms underlying the beneficial impact of saffron on neuronal viability and activity in humans, in the context of oxidative stress related to depression. |
format | Online Article Text |
id | pubmed-9002571 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-90025712022-04-13 Circulating Human Serum Metabolites Derived from the Intake of a Saffron Extract (Safr’Inside(TM)) Protect Neurons from Oxidative Stress: Consideration for Depressive Disorders Wauquier, Fabien Boutin-Wittrant, Line Pourtau, Line Gaudout, David Moras, Benjamin Vignault, Adeline Monchaux De Oliveira, Camille Gabaston, Julien Vaysse, Carole Bertrand, Karène Abrous, Hélène Capuron, Lucile Castanon, Nathalie Vauzour, David Roux, Véronique Macian, Nicolas Pickering, Gisèle Wittrant, Yohann Nutrients Article Increases in oxidative stress have been reported to play a central role in the vulnerability to depression, and antidepressant drugs may reduce increased oxidative stress in patients. Among the plants exerting anti-inflammatory and anti-oxidant properties, saffron, a spice derived from the flower of Crocus sativus, is also known for its positive effects on depression, potentially through its SSRI-like properties. However, the molecular mechanisms underlying these effects and their health benefits for humans are currently unclear. Using an original ex vivo clinical approach, we demonstrated for the first time that the circulating human metabolites produced following saffron intake (Safr’Inside(TM)) protect human neurons from oxidative-stress-induced neurotoxicity by preserving cell viability and increasing BNDF production. In particular, the metabolites significantly stimulated both dopamine and serotonin release. In addition, the saffron’s metabolites were also able to protect serotonergic tone by inhibiting the expression of the serotonin transporter SERT and down-regulating serotonin metabolism. Altogether, these data provide new biochemical insights into the mechanisms underlying the beneficial impact of saffron on neuronal viability and activity in humans, in the context of oxidative stress related to depression. MDPI 2022-04-05 /pmc/articles/PMC9002571/ /pubmed/35406124 http://dx.doi.org/10.3390/nu14071511 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Wauquier, Fabien Boutin-Wittrant, Line Pourtau, Line Gaudout, David Moras, Benjamin Vignault, Adeline Monchaux De Oliveira, Camille Gabaston, Julien Vaysse, Carole Bertrand, Karène Abrous, Hélène Capuron, Lucile Castanon, Nathalie Vauzour, David Roux, Véronique Macian, Nicolas Pickering, Gisèle Wittrant, Yohann Circulating Human Serum Metabolites Derived from the Intake of a Saffron Extract (Safr’Inside(TM)) Protect Neurons from Oxidative Stress: Consideration for Depressive Disorders |
title | Circulating Human Serum Metabolites Derived from the Intake of a Saffron Extract (Safr’Inside(TM)) Protect Neurons from Oxidative Stress: Consideration for Depressive Disorders |
title_full | Circulating Human Serum Metabolites Derived from the Intake of a Saffron Extract (Safr’Inside(TM)) Protect Neurons from Oxidative Stress: Consideration for Depressive Disorders |
title_fullStr | Circulating Human Serum Metabolites Derived from the Intake of a Saffron Extract (Safr’Inside(TM)) Protect Neurons from Oxidative Stress: Consideration for Depressive Disorders |
title_full_unstemmed | Circulating Human Serum Metabolites Derived from the Intake of a Saffron Extract (Safr’Inside(TM)) Protect Neurons from Oxidative Stress: Consideration for Depressive Disorders |
title_short | Circulating Human Serum Metabolites Derived from the Intake of a Saffron Extract (Safr’Inside(TM)) Protect Neurons from Oxidative Stress: Consideration for Depressive Disorders |
title_sort | circulating human serum metabolites derived from the intake of a saffron extract (safr’inside(tm)) protect neurons from oxidative stress: consideration for depressive disorders |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9002571/ https://www.ncbi.nlm.nih.gov/pubmed/35406124 http://dx.doi.org/10.3390/nu14071511 |
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