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The Nutraceutical Antihypertensive Action of C-Phycocyanin in Chronic Kidney Disease Is Related to the Prevention of Endothelial Dysfunction

C-phycocyanin (CPC) is an antihypertensive that is not still wholly pharmacologically described. The aim of this study was to evaluate whether CPC counteracts endothelial dysfunction as an antihypertensive mechanism in rats with 5/6 nephrectomy (NFx) as a chronic kidney disease (CKD) model. Twenty-f...

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Autores principales: Rojas-Franco, Placido, Garcia-Pliego, Erick, Vite-Aquino, Alma Gricelda, Franco-Colin, Margarita, Serrano-Contreras, Jose Ivan, Paniagua-Castro, Norma, Gallardo-Casas, Carlos Angel, Blas-Valdivia, Vanessa, Cano-Europa, Edgar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9002637/
https://www.ncbi.nlm.nih.gov/pubmed/35406077
http://dx.doi.org/10.3390/nu14071464
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author Rojas-Franco, Placido
Garcia-Pliego, Erick
Vite-Aquino, Alma Gricelda
Franco-Colin, Margarita
Serrano-Contreras, Jose Ivan
Paniagua-Castro, Norma
Gallardo-Casas, Carlos Angel
Blas-Valdivia, Vanessa
Cano-Europa, Edgar
author_facet Rojas-Franco, Placido
Garcia-Pliego, Erick
Vite-Aquino, Alma Gricelda
Franco-Colin, Margarita
Serrano-Contreras, Jose Ivan
Paniagua-Castro, Norma
Gallardo-Casas, Carlos Angel
Blas-Valdivia, Vanessa
Cano-Europa, Edgar
author_sort Rojas-Franco, Placido
collection PubMed
description C-phycocyanin (CPC) is an antihypertensive that is not still wholly pharmacologically described. The aim of this study was to evaluate whether CPC counteracts endothelial dysfunction as an antihypertensive mechanism in rats with 5/6 nephrectomy (NFx) as a chronic kidney disease (CKD) model. Twenty-four male Wistar rats were divided into four groups: sham control, sham-treated with CPC (100 mg/Kg/d), NFx, and NFx treated with CPC. Blood pressure was measured each week, and renal function evaluated at the end of the treatment. Afterward, animals were euthanized, and their thoracic aortas were analyzed for endothelium functional test, oxidative stress, and NO production. 5/6 Nephrectomy caused hypertension increasing lipid peroxidation and ROS production, overexpression of inducible nitric oxide synthase (iNOS), reduction in the first-line antioxidant enzymes activities, and reduced-glutathione (GSH) with a down-expression of eNOS. The vasomotor response reduced endothelium-dependent vasodilation in aorta segments exposed to acetylcholine and sodium nitroprusside. However, the treatment with CPC prevented hypertension by reducing oxidative stress, NO system disturbance, and endothelial dysfunction. The CPC treatment did not prevent CKD-caused disturbance in the antioxidant enzymes activities. Therefore, CPC exhibited an antihypertensive activity while avoiding endothelial dysfunction.
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spelling pubmed-90026372022-04-13 The Nutraceutical Antihypertensive Action of C-Phycocyanin in Chronic Kidney Disease Is Related to the Prevention of Endothelial Dysfunction Rojas-Franco, Placido Garcia-Pliego, Erick Vite-Aquino, Alma Gricelda Franco-Colin, Margarita Serrano-Contreras, Jose Ivan Paniagua-Castro, Norma Gallardo-Casas, Carlos Angel Blas-Valdivia, Vanessa Cano-Europa, Edgar Nutrients Article C-phycocyanin (CPC) is an antihypertensive that is not still wholly pharmacologically described. The aim of this study was to evaluate whether CPC counteracts endothelial dysfunction as an antihypertensive mechanism in rats with 5/6 nephrectomy (NFx) as a chronic kidney disease (CKD) model. Twenty-four male Wistar rats were divided into four groups: sham control, sham-treated with CPC (100 mg/Kg/d), NFx, and NFx treated with CPC. Blood pressure was measured each week, and renal function evaluated at the end of the treatment. Afterward, animals were euthanized, and their thoracic aortas were analyzed for endothelium functional test, oxidative stress, and NO production. 5/6 Nephrectomy caused hypertension increasing lipid peroxidation and ROS production, overexpression of inducible nitric oxide synthase (iNOS), reduction in the first-line antioxidant enzymes activities, and reduced-glutathione (GSH) with a down-expression of eNOS. The vasomotor response reduced endothelium-dependent vasodilation in aorta segments exposed to acetylcholine and sodium nitroprusside. However, the treatment with CPC prevented hypertension by reducing oxidative stress, NO system disturbance, and endothelial dysfunction. The CPC treatment did not prevent CKD-caused disturbance in the antioxidant enzymes activities. Therefore, CPC exhibited an antihypertensive activity while avoiding endothelial dysfunction. MDPI 2022-03-31 /pmc/articles/PMC9002637/ /pubmed/35406077 http://dx.doi.org/10.3390/nu14071464 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Rojas-Franco, Placido
Garcia-Pliego, Erick
Vite-Aquino, Alma Gricelda
Franco-Colin, Margarita
Serrano-Contreras, Jose Ivan
Paniagua-Castro, Norma
Gallardo-Casas, Carlos Angel
Blas-Valdivia, Vanessa
Cano-Europa, Edgar
The Nutraceutical Antihypertensive Action of C-Phycocyanin in Chronic Kidney Disease Is Related to the Prevention of Endothelial Dysfunction
title The Nutraceutical Antihypertensive Action of C-Phycocyanin in Chronic Kidney Disease Is Related to the Prevention of Endothelial Dysfunction
title_full The Nutraceutical Antihypertensive Action of C-Phycocyanin in Chronic Kidney Disease Is Related to the Prevention of Endothelial Dysfunction
title_fullStr The Nutraceutical Antihypertensive Action of C-Phycocyanin in Chronic Kidney Disease Is Related to the Prevention of Endothelial Dysfunction
title_full_unstemmed The Nutraceutical Antihypertensive Action of C-Phycocyanin in Chronic Kidney Disease Is Related to the Prevention of Endothelial Dysfunction
title_short The Nutraceutical Antihypertensive Action of C-Phycocyanin in Chronic Kidney Disease Is Related to the Prevention of Endothelial Dysfunction
title_sort nutraceutical antihypertensive action of c-phycocyanin in chronic kidney disease is related to the prevention of endothelial dysfunction
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9002637/
https://www.ncbi.nlm.nih.gov/pubmed/35406077
http://dx.doi.org/10.3390/nu14071464
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