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Effect of Serum Spermidine on the Prognosis in Patients with Acute Myocardial Infarction: A Cohort Study

Background: Spermidine, a natural polyamine, was found critically involved in cardioprotection and lifespan extension from both animal experiments and human studies. Aims: This study aimed to evaluate the effect of serum spermidine levels on the prognosis in patients with acute myocardial infarction...

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Autores principales: Yu, Zhecong, Jiao, Yundi, Zhang, Jin, Xu, Qianyi, Xu, Jiahui, Li, Ruixue, Yuan, Wei, Guo, Hui, Sun, Zhaoqing, Zheng, Liqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9002946/
https://www.ncbi.nlm.nih.gov/pubmed/35406007
http://dx.doi.org/10.3390/nu14071394
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author Yu, Zhecong
Jiao, Yundi
Zhang, Jin
Xu, Qianyi
Xu, Jiahui
Li, Ruixue
Yuan, Wei
Guo, Hui
Sun, Zhaoqing
Zheng, Liqiang
author_facet Yu, Zhecong
Jiao, Yundi
Zhang, Jin
Xu, Qianyi
Xu, Jiahui
Li, Ruixue
Yuan, Wei
Guo, Hui
Sun, Zhaoqing
Zheng, Liqiang
author_sort Yu, Zhecong
collection PubMed
description Background: Spermidine, a natural polyamine, was found critically involved in cardioprotection and lifespan extension from both animal experiments and human studies. Aims: This study aimed to evaluate the effect of serum spermidine levels on the prognosis in patients with acute myocardial infarction (AMI) and investigate the potential mediation effect of oxidative stress in the above relationship. Methods: We included 377 patients with AMI in a prospective cohort study and measured serum spermidine and oxidative stress indexes (superoxide dismutase enzymes, glutathione peroxidase, and Malondialdehyde) using high-performance liquid chromatography with fluorescence detector and enzyme-linked immunosorbent assay, respectively. The associations of spermidine with AMI outcomes were evaluated using Cox proportional hazards models. Results: 84 (22.3%) major adverse cardiac events (MACE) were documented during a mean follow-up of 12.3 ± 4.2 months. After multivariable adjustment, participants with serum spermidine levels of ≥15.38 ng/mL (T3) and 7.59–5.38 ng/mL (T2) had hazard ratio (HR) for recurrent AMI of 0.450 [95% confidence interval (CI): 0.213–0.984] and 0.441 (95% CI: 0.215–0.907) compared with the ≤7.59 ng/mL (T1), respectively. Participants in T3 and T2 had HR for MACE of 0.566 (95% CI: 0.329–0.947) and 0.516 (95% CI: 0.298–0.893) compared with T1. A faint J-shaped association was observed between serum spermidine levels and the risk of MACE (p-nonlinearity = 0.036). Comparisons of areas under receiver operator characteristics curves confirmed that a model including serum spermidine levels had greater predictive power than the one without it (0.733 versus 0.701, p = 0.041). A marginal statistically significant mediation effect of superoxide dismutase was shown on the association between spermidine and MACE (p = 0.091). Conclusions: Serum spermidine was associated with an improved prognosis in individuals with AMI, whereas the underlying mechanism mediated by oxidative stress was not found.
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spelling pubmed-90029462022-04-13 Effect of Serum Spermidine on the Prognosis in Patients with Acute Myocardial Infarction: A Cohort Study Yu, Zhecong Jiao, Yundi Zhang, Jin Xu, Qianyi Xu, Jiahui Li, Ruixue Yuan, Wei Guo, Hui Sun, Zhaoqing Zheng, Liqiang Nutrients Article Background: Spermidine, a natural polyamine, was found critically involved in cardioprotection and lifespan extension from both animal experiments and human studies. Aims: This study aimed to evaluate the effect of serum spermidine levels on the prognosis in patients with acute myocardial infarction (AMI) and investigate the potential mediation effect of oxidative stress in the above relationship. Methods: We included 377 patients with AMI in a prospective cohort study and measured serum spermidine and oxidative stress indexes (superoxide dismutase enzymes, glutathione peroxidase, and Malondialdehyde) using high-performance liquid chromatography with fluorescence detector and enzyme-linked immunosorbent assay, respectively. The associations of spermidine with AMI outcomes were evaluated using Cox proportional hazards models. Results: 84 (22.3%) major adverse cardiac events (MACE) were documented during a mean follow-up of 12.3 ± 4.2 months. After multivariable adjustment, participants with serum spermidine levels of ≥15.38 ng/mL (T3) and 7.59–5.38 ng/mL (T2) had hazard ratio (HR) for recurrent AMI of 0.450 [95% confidence interval (CI): 0.213–0.984] and 0.441 (95% CI: 0.215–0.907) compared with the ≤7.59 ng/mL (T1), respectively. Participants in T3 and T2 had HR for MACE of 0.566 (95% CI: 0.329–0.947) and 0.516 (95% CI: 0.298–0.893) compared with T1. A faint J-shaped association was observed between serum spermidine levels and the risk of MACE (p-nonlinearity = 0.036). Comparisons of areas under receiver operator characteristics curves confirmed that a model including serum spermidine levels had greater predictive power than the one without it (0.733 versus 0.701, p = 0.041). A marginal statistically significant mediation effect of superoxide dismutase was shown on the association between spermidine and MACE (p = 0.091). Conclusions: Serum spermidine was associated with an improved prognosis in individuals with AMI, whereas the underlying mechanism mediated by oxidative stress was not found. MDPI 2022-03-27 /pmc/articles/PMC9002946/ /pubmed/35406007 http://dx.doi.org/10.3390/nu14071394 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yu, Zhecong
Jiao, Yundi
Zhang, Jin
Xu, Qianyi
Xu, Jiahui
Li, Ruixue
Yuan, Wei
Guo, Hui
Sun, Zhaoqing
Zheng, Liqiang
Effect of Serum Spermidine on the Prognosis in Patients with Acute Myocardial Infarction: A Cohort Study
title Effect of Serum Spermidine on the Prognosis in Patients with Acute Myocardial Infarction: A Cohort Study
title_full Effect of Serum Spermidine on the Prognosis in Patients with Acute Myocardial Infarction: A Cohort Study
title_fullStr Effect of Serum Spermidine on the Prognosis in Patients with Acute Myocardial Infarction: A Cohort Study
title_full_unstemmed Effect of Serum Spermidine on the Prognosis in Patients with Acute Myocardial Infarction: A Cohort Study
title_short Effect of Serum Spermidine on the Prognosis in Patients with Acute Myocardial Infarction: A Cohort Study
title_sort effect of serum spermidine on the prognosis in patients with acute myocardial infarction: a cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9002946/
https://www.ncbi.nlm.nih.gov/pubmed/35406007
http://dx.doi.org/10.3390/nu14071394
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