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Highly Sensitive Detection of the Insecticide Azamethiphos by Tris(2,2′-bipyridine)ruthenium(II) Electrogenerated Chemiluminescence
Azamethiphos (AZA) is an insecticide and neurotoxic agent that causes the inhibition of acetylcholinesterase (AChE). AChE is a vital enzyme for neurotransmission because it metabolizes acetylcholine neurotransmitter at the synaptic cleft and terminates synaptic transmission. It is worth mentioning t...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9002990/ https://www.ncbi.nlm.nih.gov/pubmed/35408132 http://dx.doi.org/10.3390/s22072519 |
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author | Barkae, Tesfaye Hailemariam Zeid, Abdallah M. Xu, Guobao |
author_facet | Barkae, Tesfaye Hailemariam Zeid, Abdallah M. Xu, Guobao |
author_sort | Barkae, Tesfaye Hailemariam |
collection | PubMed |
description | Azamethiphos (AZA) is an insecticide and neurotoxic agent that causes the inhibition of acetylcholinesterase (AChE). AChE is a vital enzyme for neurotransmission because it metabolizes acetylcholine neurotransmitter at the synaptic cleft and terminates synaptic transmission. It is worth mentioning that organophosphates and carbamates inhibit AChE. These AChE inhibitors bind to the active site of the enzyme and inactivate it, leading to paralysis and death. Herein, for the first time, we develop a sensitive, low-cost, and rapid electrogenerated chemiluminescence (ECL) system for the detection of AZA. The designed ECL sensor was applied for the highly sensitive detection of AZA with a wide dynamic range (from 0.1 μM to 1000 μM) and low detection limit of 0.07 μM (S/N = 3). The practical utility of the sensor demonstrates high recoveries (96–102%) in real samples of lake water and wastewater. |
format | Online Article Text |
id | pubmed-9002990 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-90029902022-04-13 Highly Sensitive Detection of the Insecticide Azamethiphos by Tris(2,2′-bipyridine)ruthenium(II) Electrogenerated Chemiluminescence Barkae, Tesfaye Hailemariam Zeid, Abdallah M. Xu, Guobao Sensors (Basel) Article Azamethiphos (AZA) is an insecticide and neurotoxic agent that causes the inhibition of acetylcholinesterase (AChE). AChE is a vital enzyme for neurotransmission because it metabolizes acetylcholine neurotransmitter at the synaptic cleft and terminates synaptic transmission. It is worth mentioning that organophosphates and carbamates inhibit AChE. These AChE inhibitors bind to the active site of the enzyme and inactivate it, leading to paralysis and death. Herein, for the first time, we develop a sensitive, low-cost, and rapid electrogenerated chemiluminescence (ECL) system for the detection of AZA. The designed ECL sensor was applied for the highly sensitive detection of AZA with a wide dynamic range (from 0.1 μM to 1000 μM) and low detection limit of 0.07 μM (S/N = 3). The practical utility of the sensor demonstrates high recoveries (96–102%) in real samples of lake water and wastewater. MDPI 2022-03-25 /pmc/articles/PMC9002990/ /pubmed/35408132 http://dx.doi.org/10.3390/s22072519 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Barkae, Tesfaye Hailemariam Zeid, Abdallah M. Xu, Guobao Highly Sensitive Detection of the Insecticide Azamethiphos by Tris(2,2′-bipyridine)ruthenium(II) Electrogenerated Chemiluminescence |
title | Highly Sensitive Detection of the Insecticide Azamethiphos by Tris(2,2′-bipyridine)ruthenium(II) Electrogenerated Chemiluminescence |
title_full | Highly Sensitive Detection of the Insecticide Azamethiphos by Tris(2,2′-bipyridine)ruthenium(II) Electrogenerated Chemiluminescence |
title_fullStr | Highly Sensitive Detection of the Insecticide Azamethiphos by Tris(2,2′-bipyridine)ruthenium(II) Electrogenerated Chemiluminescence |
title_full_unstemmed | Highly Sensitive Detection of the Insecticide Azamethiphos by Tris(2,2′-bipyridine)ruthenium(II) Electrogenerated Chemiluminescence |
title_short | Highly Sensitive Detection of the Insecticide Azamethiphos by Tris(2,2′-bipyridine)ruthenium(II) Electrogenerated Chemiluminescence |
title_sort | highly sensitive detection of the insecticide azamethiphos by tris(2,2′-bipyridine)ruthenium(ii) electrogenerated chemiluminescence |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9002990/ https://www.ncbi.nlm.nih.gov/pubmed/35408132 http://dx.doi.org/10.3390/s22072519 |
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