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Effect of Vitamin D and Docosahexaenoic Acid Co-Supplementation on Vitamin D Status, Body Composition, and Metabolic Markers in Obese Children: A Randomized, Double Blind, Controlled Study

Obese children are at high risk of developing vitamin D deficiency. Omega-3 polyunsaturated fatty acids and their derivatives might have a beneficial effect on vitamin D status of obese children, due to their anti-inflammatory action, and increasing its absorption. This multicenter, randomized, doub...

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Autores principales: De Cosmi, Valentina, Mazzocchi, Alessandra, D’Oria, Veronica, Re, Alessandro, Spolidoro, Giulia Carla Immacolata, Milani, Gregorio P., Berti, Cristiana, Scaglioni, Silvia, Giavoli, Claudia, Bergamaschi, Silvia, Rodari, Giulia, Profka, Eriselda, Colombo, Roberto, Agostoni, Carlo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9003047/
https://www.ncbi.nlm.nih.gov/pubmed/35406010
http://dx.doi.org/10.3390/nu14071397
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author De Cosmi, Valentina
Mazzocchi, Alessandra
D’Oria, Veronica
Re, Alessandro
Spolidoro, Giulia Carla Immacolata
Milani, Gregorio P.
Berti, Cristiana
Scaglioni, Silvia
Giavoli, Claudia
Bergamaschi, Silvia
Rodari, Giulia
Profka, Eriselda
Colombo, Roberto
Agostoni, Carlo
author_facet De Cosmi, Valentina
Mazzocchi, Alessandra
D’Oria, Veronica
Re, Alessandro
Spolidoro, Giulia Carla Immacolata
Milani, Gregorio P.
Berti, Cristiana
Scaglioni, Silvia
Giavoli, Claudia
Bergamaschi, Silvia
Rodari, Giulia
Profka, Eriselda
Colombo, Roberto
Agostoni, Carlo
author_sort De Cosmi, Valentina
collection PubMed
description Obese children are at high risk of developing vitamin D deficiency. Omega-3 polyunsaturated fatty acids and their derivatives might have a beneficial effect on vitamin D status of obese children, due to their anti-inflammatory action, and increasing its absorption. This multicenter, randomized, double-blind controlled study aims to investigate the effect of vitamin D and docosahexaenoic acid (DHA) co-supplementation for six months on vitamin D status, body composition, and metabolic markers of obese children with vitamin D deficiency. A total of 108 children were enrolled and 73 children completed the study: 33 were supplemented with an oral dose of 500 mg of DHA and 1200 IU/day of vitamin D3 and 41 were supplemented with 1200 IU/day of vitamin D3 + wheat germ oil. At the end of the study, more than 50% of the subjects improved their vitamin D status. However, co-supplementation was not more effective than vitamin D plus wheat germ oil. Fat mass percentage was significantly reduced, and body mass index improved in both groups, even if all the subjects were still obese at the end of the study. Children receiving both vitamin D and DHA presented a higher increase of DHA levels that could be relevant to prevent inflammatory-associated complications of obesity, but they had no effect on vitamin D levels.
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spelling pubmed-90030472022-04-13 Effect of Vitamin D and Docosahexaenoic Acid Co-Supplementation on Vitamin D Status, Body Composition, and Metabolic Markers in Obese Children: A Randomized, Double Blind, Controlled Study De Cosmi, Valentina Mazzocchi, Alessandra D’Oria, Veronica Re, Alessandro Spolidoro, Giulia Carla Immacolata Milani, Gregorio P. Berti, Cristiana Scaglioni, Silvia Giavoli, Claudia Bergamaschi, Silvia Rodari, Giulia Profka, Eriselda Colombo, Roberto Agostoni, Carlo Nutrients Article Obese children are at high risk of developing vitamin D deficiency. Omega-3 polyunsaturated fatty acids and their derivatives might have a beneficial effect on vitamin D status of obese children, due to their anti-inflammatory action, and increasing its absorption. This multicenter, randomized, double-blind controlled study aims to investigate the effect of vitamin D and docosahexaenoic acid (DHA) co-supplementation for six months on vitamin D status, body composition, and metabolic markers of obese children with vitamin D deficiency. A total of 108 children were enrolled and 73 children completed the study: 33 were supplemented with an oral dose of 500 mg of DHA and 1200 IU/day of vitamin D3 and 41 were supplemented with 1200 IU/day of vitamin D3 + wheat germ oil. At the end of the study, more than 50% of the subjects improved their vitamin D status. However, co-supplementation was not more effective than vitamin D plus wheat germ oil. Fat mass percentage was significantly reduced, and body mass index improved in both groups, even if all the subjects were still obese at the end of the study. Children receiving both vitamin D and DHA presented a higher increase of DHA levels that could be relevant to prevent inflammatory-associated complications of obesity, but they had no effect on vitamin D levels. MDPI 2022-03-27 /pmc/articles/PMC9003047/ /pubmed/35406010 http://dx.doi.org/10.3390/nu14071397 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
De Cosmi, Valentina
Mazzocchi, Alessandra
D’Oria, Veronica
Re, Alessandro
Spolidoro, Giulia Carla Immacolata
Milani, Gregorio P.
Berti, Cristiana
Scaglioni, Silvia
Giavoli, Claudia
Bergamaschi, Silvia
Rodari, Giulia
Profka, Eriselda
Colombo, Roberto
Agostoni, Carlo
Effect of Vitamin D and Docosahexaenoic Acid Co-Supplementation on Vitamin D Status, Body Composition, and Metabolic Markers in Obese Children: A Randomized, Double Blind, Controlled Study
title Effect of Vitamin D and Docosahexaenoic Acid Co-Supplementation on Vitamin D Status, Body Composition, and Metabolic Markers in Obese Children: A Randomized, Double Blind, Controlled Study
title_full Effect of Vitamin D and Docosahexaenoic Acid Co-Supplementation on Vitamin D Status, Body Composition, and Metabolic Markers in Obese Children: A Randomized, Double Blind, Controlled Study
title_fullStr Effect of Vitamin D and Docosahexaenoic Acid Co-Supplementation on Vitamin D Status, Body Composition, and Metabolic Markers in Obese Children: A Randomized, Double Blind, Controlled Study
title_full_unstemmed Effect of Vitamin D and Docosahexaenoic Acid Co-Supplementation on Vitamin D Status, Body Composition, and Metabolic Markers in Obese Children: A Randomized, Double Blind, Controlled Study
title_short Effect of Vitamin D and Docosahexaenoic Acid Co-Supplementation on Vitamin D Status, Body Composition, and Metabolic Markers in Obese Children: A Randomized, Double Blind, Controlled Study
title_sort effect of vitamin d and docosahexaenoic acid co-supplementation on vitamin d status, body composition, and metabolic markers in obese children: a randomized, double blind, controlled study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9003047/
https://www.ncbi.nlm.nih.gov/pubmed/35406010
http://dx.doi.org/10.3390/nu14071397
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