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Effect of Vitamin D and Docosahexaenoic Acid Co-Supplementation on Vitamin D Status, Body Composition, and Metabolic Markers in Obese Children: A Randomized, Double Blind, Controlled Study
Obese children are at high risk of developing vitamin D deficiency. Omega-3 polyunsaturated fatty acids and their derivatives might have a beneficial effect on vitamin D status of obese children, due to their anti-inflammatory action, and increasing its absorption. This multicenter, randomized, doub...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9003047/ https://www.ncbi.nlm.nih.gov/pubmed/35406010 http://dx.doi.org/10.3390/nu14071397 |
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author | De Cosmi, Valentina Mazzocchi, Alessandra D’Oria, Veronica Re, Alessandro Spolidoro, Giulia Carla Immacolata Milani, Gregorio P. Berti, Cristiana Scaglioni, Silvia Giavoli, Claudia Bergamaschi, Silvia Rodari, Giulia Profka, Eriselda Colombo, Roberto Agostoni, Carlo |
author_facet | De Cosmi, Valentina Mazzocchi, Alessandra D’Oria, Veronica Re, Alessandro Spolidoro, Giulia Carla Immacolata Milani, Gregorio P. Berti, Cristiana Scaglioni, Silvia Giavoli, Claudia Bergamaschi, Silvia Rodari, Giulia Profka, Eriselda Colombo, Roberto Agostoni, Carlo |
author_sort | De Cosmi, Valentina |
collection | PubMed |
description | Obese children are at high risk of developing vitamin D deficiency. Omega-3 polyunsaturated fatty acids and their derivatives might have a beneficial effect on vitamin D status of obese children, due to their anti-inflammatory action, and increasing its absorption. This multicenter, randomized, double-blind controlled study aims to investigate the effect of vitamin D and docosahexaenoic acid (DHA) co-supplementation for six months on vitamin D status, body composition, and metabolic markers of obese children with vitamin D deficiency. A total of 108 children were enrolled and 73 children completed the study: 33 were supplemented with an oral dose of 500 mg of DHA and 1200 IU/day of vitamin D3 and 41 were supplemented with 1200 IU/day of vitamin D3 + wheat germ oil. At the end of the study, more than 50% of the subjects improved their vitamin D status. However, co-supplementation was not more effective than vitamin D plus wheat germ oil. Fat mass percentage was significantly reduced, and body mass index improved in both groups, even if all the subjects were still obese at the end of the study. Children receiving both vitamin D and DHA presented a higher increase of DHA levels that could be relevant to prevent inflammatory-associated complications of obesity, but they had no effect on vitamin D levels. |
format | Online Article Text |
id | pubmed-9003047 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-90030472022-04-13 Effect of Vitamin D and Docosahexaenoic Acid Co-Supplementation on Vitamin D Status, Body Composition, and Metabolic Markers in Obese Children: A Randomized, Double Blind, Controlled Study De Cosmi, Valentina Mazzocchi, Alessandra D’Oria, Veronica Re, Alessandro Spolidoro, Giulia Carla Immacolata Milani, Gregorio P. Berti, Cristiana Scaglioni, Silvia Giavoli, Claudia Bergamaschi, Silvia Rodari, Giulia Profka, Eriselda Colombo, Roberto Agostoni, Carlo Nutrients Article Obese children are at high risk of developing vitamin D deficiency. Omega-3 polyunsaturated fatty acids and their derivatives might have a beneficial effect on vitamin D status of obese children, due to their anti-inflammatory action, and increasing its absorption. This multicenter, randomized, double-blind controlled study aims to investigate the effect of vitamin D and docosahexaenoic acid (DHA) co-supplementation for six months on vitamin D status, body composition, and metabolic markers of obese children with vitamin D deficiency. A total of 108 children were enrolled and 73 children completed the study: 33 were supplemented with an oral dose of 500 mg of DHA and 1200 IU/day of vitamin D3 and 41 were supplemented with 1200 IU/day of vitamin D3 + wheat germ oil. At the end of the study, more than 50% of the subjects improved their vitamin D status. However, co-supplementation was not more effective than vitamin D plus wheat germ oil. Fat mass percentage was significantly reduced, and body mass index improved in both groups, even if all the subjects were still obese at the end of the study. Children receiving both vitamin D and DHA presented a higher increase of DHA levels that could be relevant to prevent inflammatory-associated complications of obesity, but they had no effect on vitamin D levels. MDPI 2022-03-27 /pmc/articles/PMC9003047/ /pubmed/35406010 http://dx.doi.org/10.3390/nu14071397 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article De Cosmi, Valentina Mazzocchi, Alessandra D’Oria, Veronica Re, Alessandro Spolidoro, Giulia Carla Immacolata Milani, Gregorio P. Berti, Cristiana Scaglioni, Silvia Giavoli, Claudia Bergamaschi, Silvia Rodari, Giulia Profka, Eriselda Colombo, Roberto Agostoni, Carlo Effect of Vitamin D and Docosahexaenoic Acid Co-Supplementation on Vitamin D Status, Body Composition, and Metabolic Markers in Obese Children: A Randomized, Double Blind, Controlled Study |
title | Effect of Vitamin D and Docosahexaenoic Acid Co-Supplementation on Vitamin D Status, Body Composition, and Metabolic Markers in Obese Children: A Randomized, Double Blind, Controlled Study |
title_full | Effect of Vitamin D and Docosahexaenoic Acid Co-Supplementation on Vitamin D Status, Body Composition, and Metabolic Markers in Obese Children: A Randomized, Double Blind, Controlled Study |
title_fullStr | Effect of Vitamin D and Docosahexaenoic Acid Co-Supplementation on Vitamin D Status, Body Composition, and Metabolic Markers in Obese Children: A Randomized, Double Blind, Controlled Study |
title_full_unstemmed | Effect of Vitamin D and Docosahexaenoic Acid Co-Supplementation on Vitamin D Status, Body Composition, and Metabolic Markers in Obese Children: A Randomized, Double Blind, Controlled Study |
title_short | Effect of Vitamin D and Docosahexaenoic Acid Co-Supplementation on Vitamin D Status, Body Composition, and Metabolic Markers in Obese Children: A Randomized, Double Blind, Controlled Study |
title_sort | effect of vitamin d and docosahexaenoic acid co-supplementation on vitamin d status, body composition, and metabolic markers in obese children: a randomized, double blind, controlled study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9003047/ https://www.ncbi.nlm.nih.gov/pubmed/35406010 http://dx.doi.org/10.3390/nu14071397 |
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