Cargando…

Gastrointestinal Symptoms in Autism Spectrum Disorder: A Systematic Review

This systematic review aims to offer an updated understanding of the relationship between gastrointestinal symptoms (GIS) and autism spectrum disorder (ASD) in children and adolescents. The databases PsycINFO, Medline, Cinahl, and ERIC were searched using keywords, and relevant literature was hand-s...

Descripción completa

Detalles Bibliográficos
Autores principales: Leader, Geraldine, Abberton, Cathal, Cunningham, Stephen, Gilmartin, Katie, Grudzien, Margo, Higgins, Emily, Joshi, Lokesh, Whelan, Sally, Mannion, Arlene
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9003052/
https://www.ncbi.nlm.nih.gov/pubmed/35406084
http://dx.doi.org/10.3390/nu14071471
_version_ 1784686039836655616
author Leader, Geraldine
Abberton, Cathal
Cunningham, Stephen
Gilmartin, Katie
Grudzien, Margo
Higgins, Emily
Joshi, Lokesh
Whelan, Sally
Mannion, Arlene
author_facet Leader, Geraldine
Abberton, Cathal
Cunningham, Stephen
Gilmartin, Katie
Grudzien, Margo
Higgins, Emily
Joshi, Lokesh
Whelan, Sally
Mannion, Arlene
author_sort Leader, Geraldine
collection PubMed
description This systematic review aims to offer an updated understanding of the relationship between gastrointestinal symptoms (GIS) and autism spectrum disorder (ASD) in children and adolescents. The databases PsycINFO, Medline, Cinahl, and ERIC were searched using keywords, and relevant literature was hand-searched. Papers (n = 3319) were systematically screened and deemed eligible if they were empirical studies published in English since 2014 and measured the GIS of individuals with ASD who were under 18 years old. Thirty studies were included in the final review. The study findings were synthesized under eight themes, including the prevalence and nature of GIS and their relationship with developmental regression, language and communication, ASD severity, challenging behavior, comorbid psychopathology, sleep problems, and sensory issues. The review found that GIS were common and that there was contradictory evidence concerning their relationship with co-occurring conditions. It also identified evidence of some causal relationships that support the existence of the gut–immune–brain pathways. Future research needs to use large prospective designs and objective and standardized GIS measurements to provide a nuanced understanding of GIS in the context of ASD.
format Online
Article
Text
id pubmed-9003052
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-90030522022-04-13 Gastrointestinal Symptoms in Autism Spectrum Disorder: A Systematic Review Leader, Geraldine Abberton, Cathal Cunningham, Stephen Gilmartin, Katie Grudzien, Margo Higgins, Emily Joshi, Lokesh Whelan, Sally Mannion, Arlene Nutrients Review This systematic review aims to offer an updated understanding of the relationship between gastrointestinal symptoms (GIS) and autism spectrum disorder (ASD) in children and adolescents. The databases PsycINFO, Medline, Cinahl, and ERIC were searched using keywords, and relevant literature was hand-searched. Papers (n = 3319) were systematically screened and deemed eligible if they were empirical studies published in English since 2014 and measured the GIS of individuals with ASD who were under 18 years old. Thirty studies were included in the final review. The study findings were synthesized under eight themes, including the prevalence and nature of GIS and their relationship with developmental regression, language and communication, ASD severity, challenging behavior, comorbid psychopathology, sleep problems, and sensory issues. The review found that GIS were common and that there was contradictory evidence concerning their relationship with co-occurring conditions. It also identified evidence of some causal relationships that support the existence of the gut–immune–brain pathways. Future research needs to use large prospective designs and objective and standardized GIS measurements to provide a nuanced understanding of GIS in the context of ASD. MDPI 2022-04-01 /pmc/articles/PMC9003052/ /pubmed/35406084 http://dx.doi.org/10.3390/nu14071471 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Leader, Geraldine
Abberton, Cathal
Cunningham, Stephen
Gilmartin, Katie
Grudzien, Margo
Higgins, Emily
Joshi, Lokesh
Whelan, Sally
Mannion, Arlene
Gastrointestinal Symptoms in Autism Spectrum Disorder: A Systematic Review
title Gastrointestinal Symptoms in Autism Spectrum Disorder: A Systematic Review
title_full Gastrointestinal Symptoms in Autism Spectrum Disorder: A Systematic Review
title_fullStr Gastrointestinal Symptoms in Autism Spectrum Disorder: A Systematic Review
title_full_unstemmed Gastrointestinal Symptoms in Autism Spectrum Disorder: A Systematic Review
title_short Gastrointestinal Symptoms in Autism Spectrum Disorder: A Systematic Review
title_sort gastrointestinal symptoms in autism spectrum disorder: a systematic review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9003052/
https://www.ncbi.nlm.nih.gov/pubmed/35406084
http://dx.doi.org/10.3390/nu14071471
work_keys_str_mv AT leadergeraldine gastrointestinalsymptomsinautismspectrumdisorderasystematicreview
AT abbertoncathal gastrointestinalsymptomsinautismspectrumdisorderasystematicreview
AT cunninghamstephen gastrointestinalsymptomsinautismspectrumdisorderasystematicreview
AT gilmartinkatie gastrointestinalsymptomsinautismspectrumdisorderasystematicreview
AT grudzienmargo gastrointestinalsymptomsinautismspectrumdisorderasystematicreview
AT higginsemily gastrointestinalsymptomsinautismspectrumdisorderasystematicreview
AT joshilokesh gastrointestinalsymptomsinautismspectrumdisorderasystematicreview
AT whelansally gastrointestinalsymptomsinautismspectrumdisorderasystematicreview
AT mannionarlene gastrointestinalsymptomsinautismspectrumdisorderasystematicreview