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Gastrointestinal Symptoms in Autism Spectrum Disorder: A Systematic Review
This systematic review aims to offer an updated understanding of the relationship between gastrointestinal symptoms (GIS) and autism spectrum disorder (ASD) in children and adolescents. The databases PsycINFO, Medline, Cinahl, and ERIC were searched using keywords, and relevant literature was hand-s...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9003052/ https://www.ncbi.nlm.nih.gov/pubmed/35406084 http://dx.doi.org/10.3390/nu14071471 |
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author | Leader, Geraldine Abberton, Cathal Cunningham, Stephen Gilmartin, Katie Grudzien, Margo Higgins, Emily Joshi, Lokesh Whelan, Sally Mannion, Arlene |
author_facet | Leader, Geraldine Abberton, Cathal Cunningham, Stephen Gilmartin, Katie Grudzien, Margo Higgins, Emily Joshi, Lokesh Whelan, Sally Mannion, Arlene |
author_sort | Leader, Geraldine |
collection | PubMed |
description | This systematic review aims to offer an updated understanding of the relationship between gastrointestinal symptoms (GIS) and autism spectrum disorder (ASD) in children and adolescents. The databases PsycINFO, Medline, Cinahl, and ERIC were searched using keywords, and relevant literature was hand-searched. Papers (n = 3319) were systematically screened and deemed eligible if they were empirical studies published in English since 2014 and measured the GIS of individuals with ASD who were under 18 years old. Thirty studies were included in the final review. The study findings were synthesized under eight themes, including the prevalence and nature of GIS and their relationship with developmental regression, language and communication, ASD severity, challenging behavior, comorbid psychopathology, sleep problems, and sensory issues. The review found that GIS were common and that there was contradictory evidence concerning their relationship with co-occurring conditions. It also identified evidence of some causal relationships that support the existence of the gut–immune–brain pathways. Future research needs to use large prospective designs and objective and standardized GIS measurements to provide a nuanced understanding of GIS in the context of ASD. |
format | Online Article Text |
id | pubmed-9003052 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-90030522022-04-13 Gastrointestinal Symptoms in Autism Spectrum Disorder: A Systematic Review Leader, Geraldine Abberton, Cathal Cunningham, Stephen Gilmartin, Katie Grudzien, Margo Higgins, Emily Joshi, Lokesh Whelan, Sally Mannion, Arlene Nutrients Review This systematic review aims to offer an updated understanding of the relationship between gastrointestinal symptoms (GIS) and autism spectrum disorder (ASD) in children and adolescents. The databases PsycINFO, Medline, Cinahl, and ERIC were searched using keywords, and relevant literature was hand-searched. Papers (n = 3319) were systematically screened and deemed eligible if they were empirical studies published in English since 2014 and measured the GIS of individuals with ASD who were under 18 years old. Thirty studies were included in the final review. The study findings were synthesized under eight themes, including the prevalence and nature of GIS and their relationship with developmental regression, language and communication, ASD severity, challenging behavior, comorbid psychopathology, sleep problems, and sensory issues. The review found that GIS were common and that there was contradictory evidence concerning their relationship with co-occurring conditions. It also identified evidence of some causal relationships that support the existence of the gut–immune–brain pathways. Future research needs to use large prospective designs and objective and standardized GIS measurements to provide a nuanced understanding of GIS in the context of ASD. MDPI 2022-04-01 /pmc/articles/PMC9003052/ /pubmed/35406084 http://dx.doi.org/10.3390/nu14071471 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Leader, Geraldine Abberton, Cathal Cunningham, Stephen Gilmartin, Katie Grudzien, Margo Higgins, Emily Joshi, Lokesh Whelan, Sally Mannion, Arlene Gastrointestinal Symptoms in Autism Spectrum Disorder: A Systematic Review |
title | Gastrointestinal Symptoms in Autism Spectrum Disorder: A Systematic Review |
title_full | Gastrointestinal Symptoms in Autism Spectrum Disorder: A Systematic Review |
title_fullStr | Gastrointestinal Symptoms in Autism Spectrum Disorder: A Systematic Review |
title_full_unstemmed | Gastrointestinal Symptoms in Autism Spectrum Disorder: A Systematic Review |
title_short | Gastrointestinal Symptoms in Autism Spectrum Disorder: A Systematic Review |
title_sort | gastrointestinal symptoms in autism spectrum disorder: a systematic review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9003052/ https://www.ncbi.nlm.nih.gov/pubmed/35406084 http://dx.doi.org/10.3390/nu14071471 |
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