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Targeting Cardiovascular Diseases by Flavonols: An Update
Flavonols are one of the most plentiful flavonoid subclasses found in natural products and are extensively used as dietary supplements. Numerous in vitro and in vivo studies have shown the cardioprotective properties of flavonols, especially quercetin. This group of substances exerts positive impact...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9003055/ https://www.ncbi.nlm.nih.gov/pubmed/35406050 http://dx.doi.org/10.3390/nu14071439 |
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author | Kozłowska, Aleksandra Szostak-Węgierek, Dorota |
author_facet | Kozłowska, Aleksandra Szostak-Węgierek, Dorota |
author_sort | Kozłowska, Aleksandra |
collection | PubMed |
description | Flavonols are one of the most plentiful flavonoid subclasses found in natural products and are extensively used as dietary supplements. Numerous in vitro and in vivo studies have shown the cardioprotective properties of flavonols, especially quercetin. This group of substances exerts positive impacts primarily due to their antiatherogenic, antithrombotic, and antioxidant activities. The potential of flavonols to promote vasodilation and regulation of apoptotic processes in the endothelium are other beneficial effects on the cardiovascular system. Despite promising experimental findings, randomized controlled trials and meta-analyses have yielded inconsistent results on the influence of these substances on human cardiovascular parameters. Thus, this review aims to summarize the most recent clinical data on the intake of these substances and their effects on the cardiovascular system. The present study will help clinicians and other healthcare workers understand the value of flavonol supplementation in both subjects at risk for cardiovascular disease and patients with cardiovascular diseases. |
format | Online Article Text |
id | pubmed-9003055 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-90030552022-04-13 Targeting Cardiovascular Diseases by Flavonols: An Update Kozłowska, Aleksandra Szostak-Węgierek, Dorota Nutrients Review Flavonols are one of the most plentiful flavonoid subclasses found in natural products and are extensively used as dietary supplements. Numerous in vitro and in vivo studies have shown the cardioprotective properties of flavonols, especially quercetin. This group of substances exerts positive impacts primarily due to their antiatherogenic, antithrombotic, and antioxidant activities. The potential of flavonols to promote vasodilation and regulation of apoptotic processes in the endothelium are other beneficial effects on the cardiovascular system. Despite promising experimental findings, randomized controlled trials and meta-analyses have yielded inconsistent results on the influence of these substances on human cardiovascular parameters. Thus, this review aims to summarize the most recent clinical data on the intake of these substances and their effects on the cardiovascular system. The present study will help clinicians and other healthcare workers understand the value of flavonol supplementation in both subjects at risk for cardiovascular disease and patients with cardiovascular diseases. MDPI 2022-03-30 /pmc/articles/PMC9003055/ /pubmed/35406050 http://dx.doi.org/10.3390/nu14071439 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Kozłowska, Aleksandra Szostak-Węgierek, Dorota Targeting Cardiovascular Diseases by Flavonols: An Update |
title | Targeting Cardiovascular Diseases by Flavonols: An Update |
title_full | Targeting Cardiovascular Diseases by Flavonols: An Update |
title_fullStr | Targeting Cardiovascular Diseases by Flavonols: An Update |
title_full_unstemmed | Targeting Cardiovascular Diseases by Flavonols: An Update |
title_short | Targeting Cardiovascular Diseases by Flavonols: An Update |
title_sort | targeting cardiovascular diseases by flavonols: an update |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9003055/ https://www.ncbi.nlm.nih.gov/pubmed/35406050 http://dx.doi.org/10.3390/nu14071439 |
work_keys_str_mv | AT kozłowskaaleksandra targetingcardiovasculardiseasesbyflavonolsanupdate AT szostakwegierekdorota targetingcardiovasculardiseasesbyflavonolsanupdate |