Cargando…
A High-Protein and Low-Glycemic Formula Diet Improves Blood Pressure and Other Hemodynamic Parameters in High-Risk Individuals
Low-caloric formula diets can improve hemodynamic parameters of patients with type 2 diabetes. We, therefore, hypothesized that persons with overweight or obesity can benefit from a high-protein, low-glycemic but moderate-caloric formula diet. This post-hoc analysis of the Almased Concept against Ov...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9003071/ https://www.ncbi.nlm.nih.gov/pubmed/35406053 http://dx.doi.org/10.3390/nu14071443 |
_version_ | 1784686044237529088 |
---|---|
author | Röhling, Martin Kempf, Kerstin Banzer, Winfried Braumann, Klaus Michael Führer-Sakel, Dagmar Halle, Martin McCarthy, David Martin, Stephan Scholze, Jürgen Toplak, Hermann Berg, Aloys Predel, Hans-Georg |
author_facet | Röhling, Martin Kempf, Kerstin Banzer, Winfried Braumann, Klaus Michael Führer-Sakel, Dagmar Halle, Martin McCarthy, David Martin, Stephan Scholze, Jürgen Toplak, Hermann Berg, Aloys Predel, Hans-Georg |
author_sort | Röhling, Martin |
collection | PubMed |
description | Low-caloric formula diets can improve hemodynamic parameters of patients with type 2 diabetes. We, therefore, hypothesized that persons with overweight or obesity can benefit from a high-protein, low-glycemic but moderate-caloric formula diet. This post-hoc analysis of the Almased Concept against Overweight and Obesity and Related Health Risk- (ACOORH) trial investigated the impact of a lifestyle intervention combined with a formula diet (INT, n = 308) compared to a control group with lifestyle intervention alone (CON, n = 155) on hemodynamic parameters (systolic and diastolic blood pressure (SBP, DBP), resting heart rate (HR), and pulse wave velocity (PWV)) in high-risk individuals with prehypertension or hypertension. INT replaced meals during the first 6 months (1 week: 3 meals/day; 2–4 weeks: 2 meals/day; 5–26 weeks: 1 meal/day). Study duration was 12 months. From the starting cohort, 304 (68.3%, INT: n = 216; CON: n = 101) participants had a complete dataset. Compared to CON, INT significantly reduced more SBP (−7.3 mmHg 95% CI [−9.2; −5.3] vs. −3.3 mmHg [−5.9; −0.8], p < 0.049) and DBP (−3.7 mmHg [−4.9; −2.5] vs. −1.4 mmHg [−3.1; 0.2], p < 0.028) after 12 months. Compared to CON, INT showed a pronounced reduction in resting HR and PWV after 6 months but both lost significance after 12 months. Changes in SBP, DBP, and PWV were significantly associated positively with changes in body weight and fat mass (all p < 0.05) and resting HR correlated positively with fasting insulin (p < 0.001) after 12 months. Combining a lifestyle intervention with a high-protein and low-glycemic formula diet improves hemodynamic parameters to a greater extent than lifestyle intervention alone in high-risk individuals with overweight and obesity. |
format | Online Article Text |
id | pubmed-9003071 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-90030712022-04-13 A High-Protein and Low-Glycemic Formula Diet Improves Blood Pressure and Other Hemodynamic Parameters in High-Risk Individuals Röhling, Martin Kempf, Kerstin Banzer, Winfried Braumann, Klaus Michael Führer-Sakel, Dagmar Halle, Martin McCarthy, David Martin, Stephan Scholze, Jürgen Toplak, Hermann Berg, Aloys Predel, Hans-Georg Nutrients Article Low-caloric formula diets can improve hemodynamic parameters of patients with type 2 diabetes. We, therefore, hypothesized that persons with overweight or obesity can benefit from a high-protein, low-glycemic but moderate-caloric formula diet. This post-hoc analysis of the Almased Concept against Overweight and Obesity and Related Health Risk- (ACOORH) trial investigated the impact of a lifestyle intervention combined with a formula diet (INT, n = 308) compared to a control group with lifestyle intervention alone (CON, n = 155) on hemodynamic parameters (systolic and diastolic blood pressure (SBP, DBP), resting heart rate (HR), and pulse wave velocity (PWV)) in high-risk individuals with prehypertension or hypertension. INT replaced meals during the first 6 months (1 week: 3 meals/day; 2–4 weeks: 2 meals/day; 5–26 weeks: 1 meal/day). Study duration was 12 months. From the starting cohort, 304 (68.3%, INT: n = 216; CON: n = 101) participants had a complete dataset. Compared to CON, INT significantly reduced more SBP (−7.3 mmHg 95% CI [−9.2; −5.3] vs. −3.3 mmHg [−5.9; −0.8], p < 0.049) and DBP (−3.7 mmHg [−4.9; −2.5] vs. −1.4 mmHg [−3.1; 0.2], p < 0.028) after 12 months. Compared to CON, INT showed a pronounced reduction in resting HR and PWV after 6 months but both lost significance after 12 months. Changes in SBP, DBP, and PWV were significantly associated positively with changes in body weight and fat mass (all p < 0.05) and resting HR correlated positively with fasting insulin (p < 0.001) after 12 months. Combining a lifestyle intervention with a high-protein and low-glycemic formula diet improves hemodynamic parameters to a greater extent than lifestyle intervention alone in high-risk individuals with overweight and obesity. MDPI 2022-03-30 /pmc/articles/PMC9003071/ /pubmed/35406053 http://dx.doi.org/10.3390/nu14071443 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Röhling, Martin Kempf, Kerstin Banzer, Winfried Braumann, Klaus Michael Führer-Sakel, Dagmar Halle, Martin McCarthy, David Martin, Stephan Scholze, Jürgen Toplak, Hermann Berg, Aloys Predel, Hans-Georg A High-Protein and Low-Glycemic Formula Diet Improves Blood Pressure and Other Hemodynamic Parameters in High-Risk Individuals |
title | A High-Protein and Low-Glycemic Formula Diet Improves Blood Pressure and Other Hemodynamic Parameters in High-Risk Individuals |
title_full | A High-Protein and Low-Glycemic Formula Diet Improves Blood Pressure and Other Hemodynamic Parameters in High-Risk Individuals |
title_fullStr | A High-Protein and Low-Glycemic Formula Diet Improves Blood Pressure and Other Hemodynamic Parameters in High-Risk Individuals |
title_full_unstemmed | A High-Protein and Low-Glycemic Formula Diet Improves Blood Pressure and Other Hemodynamic Parameters in High-Risk Individuals |
title_short | A High-Protein and Low-Glycemic Formula Diet Improves Blood Pressure and Other Hemodynamic Parameters in High-Risk Individuals |
title_sort | high-protein and low-glycemic formula diet improves blood pressure and other hemodynamic parameters in high-risk individuals |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9003071/ https://www.ncbi.nlm.nih.gov/pubmed/35406053 http://dx.doi.org/10.3390/nu14071443 |
work_keys_str_mv | AT rohlingmartin ahighproteinandlowglycemicformuladietimprovesbloodpressureandotherhemodynamicparametersinhighriskindividuals AT kempfkerstin ahighproteinandlowglycemicformuladietimprovesbloodpressureandotherhemodynamicparametersinhighriskindividuals AT banzerwinfried ahighproteinandlowglycemicformuladietimprovesbloodpressureandotherhemodynamicparametersinhighriskindividuals AT braumannklausmichael ahighproteinandlowglycemicformuladietimprovesbloodpressureandotherhemodynamicparametersinhighriskindividuals AT fuhrersakeldagmar ahighproteinandlowglycemicformuladietimprovesbloodpressureandotherhemodynamicparametersinhighriskindividuals AT hallemartin ahighproteinandlowglycemicformuladietimprovesbloodpressureandotherhemodynamicparametersinhighriskindividuals AT mccarthydavid ahighproteinandlowglycemicformuladietimprovesbloodpressureandotherhemodynamicparametersinhighriskindividuals AT martinstephan ahighproteinandlowglycemicformuladietimprovesbloodpressureandotherhemodynamicparametersinhighriskindividuals AT scholzejurgen ahighproteinandlowglycemicformuladietimprovesbloodpressureandotherhemodynamicparametersinhighriskindividuals AT toplakhermann ahighproteinandlowglycemicformuladietimprovesbloodpressureandotherhemodynamicparametersinhighriskindividuals AT bergaloys ahighproteinandlowglycemicformuladietimprovesbloodpressureandotherhemodynamicparametersinhighriskindividuals AT predelhansgeorg ahighproteinandlowglycemicformuladietimprovesbloodpressureandotherhemodynamicparametersinhighriskindividuals AT ahighproteinandlowglycemicformuladietimprovesbloodpressureandotherhemodynamicparametersinhighriskindividuals AT rohlingmartin highproteinandlowglycemicformuladietimprovesbloodpressureandotherhemodynamicparametersinhighriskindividuals AT kempfkerstin highproteinandlowglycemicformuladietimprovesbloodpressureandotherhemodynamicparametersinhighriskindividuals AT banzerwinfried highproteinandlowglycemicformuladietimprovesbloodpressureandotherhemodynamicparametersinhighriskindividuals AT braumannklausmichael highproteinandlowglycemicformuladietimprovesbloodpressureandotherhemodynamicparametersinhighriskindividuals AT fuhrersakeldagmar highproteinandlowglycemicformuladietimprovesbloodpressureandotherhemodynamicparametersinhighriskindividuals AT hallemartin highproteinandlowglycemicformuladietimprovesbloodpressureandotherhemodynamicparametersinhighriskindividuals AT mccarthydavid highproteinandlowglycemicformuladietimprovesbloodpressureandotherhemodynamicparametersinhighriskindividuals AT martinstephan highproteinandlowglycemicformuladietimprovesbloodpressureandotherhemodynamicparametersinhighriskindividuals AT scholzejurgen highproteinandlowglycemicformuladietimprovesbloodpressureandotherhemodynamicparametersinhighriskindividuals AT toplakhermann highproteinandlowglycemicformuladietimprovesbloodpressureandotherhemodynamicparametersinhighriskindividuals AT bergaloys highproteinandlowglycemicformuladietimprovesbloodpressureandotherhemodynamicparametersinhighriskindividuals AT predelhansgeorg highproteinandlowglycemicformuladietimprovesbloodpressureandotherhemodynamicparametersinhighriskindividuals AT highproteinandlowglycemicformuladietimprovesbloodpressureandotherhemodynamicparametersinhighriskindividuals |