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A High-Protein and Low-Glycemic Formula Diet Improves Blood Pressure and Other Hemodynamic Parameters in High-Risk Individuals

Low-caloric formula diets can improve hemodynamic parameters of patients with type 2 diabetes. We, therefore, hypothesized that persons with overweight or obesity can benefit from a high-protein, low-glycemic but moderate-caloric formula diet. This post-hoc analysis of the Almased Concept against Ov...

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Autores principales: Röhling, Martin, Kempf, Kerstin, Banzer, Winfried, Braumann, Klaus Michael, Führer-Sakel, Dagmar, Halle, Martin, McCarthy, David, Martin, Stephan, Scholze, Jürgen, Toplak, Hermann, Berg, Aloys, Predel, Hans-Georg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9003071/
https://www.ncbi.nlm.nih.gov/pubmed/35406053
http://dx.doi.org/10.3390/nu14071443
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author Röhling, Martin
Kempf, Kerstin
Banzer, Winfried
Braumann, Klaus Michael
Führer-Sakel, Dagmar
Halle, Martin
McCarthy, David
Martin, Stephan
Scholze, Jürgen
Toplak, Hermann
Berg, Aloys
Predel, Hans-Georg
author_facet Röhling, Martin
Kempf, Kerstin
Banzer, Winfried
Braumann, Klaus Michael
Führer-Sakel, Dagmar
Halle, Martin
McCarthy, David
Martin, Stephan
Scholze, Jürgen
Toplak, Hermann
Berg, Aloys
Predel, Hans-Georg
author_sort Röhling, Martin
collection PubMed
description Low-caloric formula diets can improve hemodynamic parameters of patients with type 2 diabetes. We, therefore, hypothesized that persons with overweight or obesity can benefit from a high-protein, low-glycemic but moderate-caloric formula diet. This post-hoc analysis of the Almased Concept against Overweight and Obesity and Related Health Risk- (ACOORH) trial investigated the impact of a lifestyle intervention combined with a formula diet (INT, n = 308) compared to a control group with lifestyle intervention alone (CON, n = 155) on hemodynamic parameters (systolic and diastolic blood pressure (SBP, DBP), resting heart rate (HR), and pulse wave velocity (PWV)) in high-risk individuals with prehypertension or hypertension. INT replaced meals during the first 6 months (1 week: 3 meals/day; 2–4 weeks: 2 meals/day; 5–26 weeks: 1 meal/day). Study duration was 12 months. From the starting cohort, 304 (68.3%, INT: n = 216; CON: n = 101) participants had a complete dataset. Compared to CON, INT significantly reduced more SBP (−7.3 mmHg 95% CI [−9.2; −5.3] vs. −3.3 mmHg [−5.9; −0.8], p < 0.049) and DBP (−3.7 mmHg [−4.9; −2.5] vs. −1.4 mmHg [−3.1; 0.2], p < 0.028) after 12 months. Compared to CON, INT showed a pronounced reduction in resting HR and PWV after 6 months but both lost significance after 12 months. Changes in SBP, DBP, and PWV were significantly associated positively with changes in body weight and fat mass (all p < 0.05) and resting HR correlated positively with fasting insulin (p < 0.001) after 12 months. Combining a lifestyle intervention with a high-protein and low-glycemic formula diet improves hemodynamic parameters to a greater extent than lifestyle intervention alone in high-risk individuals with overweight and obesity.
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spelling pubmed-90030712022-04-13 A High-Protein and Low-Glycemic Formula Diet Improves Blood Pressure and Other Hemodynamic Parameters in High-Risk Individuals Röhling, Martin Kempf, Kerstin Banzer, Winfried Braumann, Klaus Michael Führer-Sakel, Dagmar Halle, Martin McCarthy, David Martin, Stephan Scholze, Jürgen Toplak, Hermann Berg, Aloys Predel, Hans-Georg Nutrients Article Low-caloric formula diets can improve hemodynamic parameters of patients with type 2 diabetes. We, therefore, hypothesized that persons with overweight or obesity can benefit from a high-protein, low-glycemic but moderate-caloric formula diet. This post-hoc analysis of the Almased Concept against Overweight and Obesity and Related Health Risk- (ACOORH) trial investigated the impact of a lifestyle intervention combined with a formula diet (INT, n = 308) compared to a control group with lifestyle intervention alone (CON, n = 155) on hemodynamic parameters (systolic and diastolic blood pressure (SBP, DBP), resting heart rate (HR), and pulse wave velocity (PWV)) in high-risk individuals with prehypertension or hypertension. INT replaced meals during the first 6 months (1 week: 3 meals/day; 2–4 weeks: 2 meals/day; 5–26 weeks: 1 meal/day). Study duration was 12 months. From the starting cohort, 304 (68.3%, INT: n = 216; CON: n = 101) participants had a complete dataset. Compared to CON, INT significantly reduced more SBP (−7.3 mmHg 95% CI [−9.2; −5.3] vs. −3.3 mmHg [−5.9; −0.8], p < 0.049) and DBP (−3.7 mmHg [−4.9; −2.5] vs. −1.4 mmHg [−3.1; 0.2], p < 0.028) after 12 months. Compared to CON, INT showed a pronounced reduction in resting HR and PWV after 6 months but both lost significance after 12 months. Changes in SBP, DBP, and PWV were significantly associated positively with changes in body weight and fat mass (all p < 0.05) and resting HR correlated positively with fasting insulin (p < 0.001) after 12 months. Combining a lifestyle intervention with a high-protein and low-glycemic formula diet improves hemodynamic parameters to a greater extent than lifestyle intervention alone in high-risk individuals with overweight and obesity. MDPI 2022-03-30 /pmc/articles/PMC9003071/ /pubmed/35406053 http://dx.doi.org/10.3390/nu14071443 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Röhling, Martin
Kempf, Kerstin
Banzer, Winfried
Braumann, Klaus Michael
Führer-Sakel, Dagmar
Halle, Martin
McCarthy, David
Martin, Stephan
Scholze, Jürgen
Toplak, Hermann
Berg, Aloys
Predel, Hans-Georg
A High-Protein and Low-Glycemic Formula Diet Improves Blood Pressure and Other Hemodynamic Parameters in High-Risk Individuals
title A High-Protein and Low-Glycemic Formula Diet Improves Blood Pressure and Other Hemodynamic Parameters in High-Risk Individuals
title_full A High-Protein and Low-Glycemic Formula Diet Improves Blood Pressure and Other Hemodynamic Parameters in High-Risk Individuals
title_fullStr A High-Protein and Low-Glycemic Formula Diet Improves Blood Pressure and Other Hemodynamic Parameters in High-Risk Individuals
title_full_unstemmed A High-Protein and Low-Glycemic Formula Diet Improves Blood Pressure and Other Hemodynamic Parameters in High-Risk Individuals
title_short A High-Protein and Low-Glycemic Formula Diet Improves Blood Pressure and Other Hemodynamic Parameters in High-Risk Individuals
title_sort high-protein and low-glycemic formula diet improves blood pressure and other hemodynamic parameters in high-risk individuals
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9003071/
https://www.ncbi.nlm.nih.gov/pubmed/35406053
http://dx.doi.org/10.3390/nu14071443
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