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The Association between Lead Exposure and Bone Mineral Density in Childhood and Adolescence: Results from NHANES 1999–2006 and 2011–2018

There are few studies on lead’s effect on bone mineral density (BMD) in childhood. In this study, we examined the association between lead exposure and BMD among 13,951 children and adolescents aged 8–19 years from NHANES 1999–2006 and 2011–2018. The whole blood lead levels (BLLs) were used as lead...

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Autores principales: Li, Tao, Xie, Yixuan, Wang, Liang, Huang, Guimin, Cheng, Yijing, Hou, Dongqing, Liu, Wenqian, Zhang, Tong, Liu, Junting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9003082/
https://www.ncbi.nlm.nih.gov/pubmed/35406136
http://dx.doi.org/10.3390/nu14071523
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author Li, Tao
Xie, Yixuan
Wang, Liang
Huang, Guimin
Cheng, Yijing
Hou, Dongqing
Liu, Wenqian
Zhang, Tong
Liu, Junting
author_facet Li, Tao
Xie, Yixuan
Wang, Liang
Huang, Guimin
Cheng, Yijing
Hou, Dongqing
Liu, Wenqian
Zhang, Tong
Liu, Junting
author_sort Li, Tao
collection PubMed
description There are few studies on lead’s effect on bone mineral density (BMD) in childhood. In this study, we examined the association between lead exposure and BMD among 13,951 children and adolescents aged 8–19 years from NHANES 1999–2006 and 2011–2018. The whole blood lead levels (BLLs) were used as lead exposure biomarkers, and total BMD, subtotal BMD, lumbar spine BMD and limb BMD were used as outcome variables. The survey weighted multivariable generalized additive models (GAMs) with smoothing terms were used to explore the association between blood lead levels and BMDs, adjusted for age, sex, race/ethnicity, height, weight, family-income-to-poverty ratio and blood cadmium. Subgroup analyses stratified by sex and bony sites were further performed. We found an N-shaped curve association between BLLs and total BMD, subtotal BMD and limb BMD for males and females, whereas the association between BLLs and lumbar spine BMD was only significantly negative for females. The findings suggested that lead exposure had different effects on BMD of different bony sites (highly cortical or trabecular regions) in childhood and adolescence and had different effects on the same bone among different ages population and/or at different levels.
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spelling pubmed-90030822022-04-13 The Association between Lead Exposure and Bone Mineral Density in Childhood and Adolescence: Results from NHANES 1999–2006 and 2011–2018 Li, Tao Xie, Yixuan Wang, Liang Huang, Guimin Cheng, Yijing Hou, Dongqing Liu, Wenqian Zhang, Tong Liu, Junting Nutrients Article There are few studies on lead’s effect on bone mineral density (BMD) in childhood. In this study, we examined the association between lead exposure and BMD among 13,951 children and adolescents aged 8–19 years from NHANES 1999–2006 and 2011–2018. The whole blood lead levels (BLLs) were used as lead exposure biomarkers, and total BMD, subtotal BMD, lumbar spine BMD and limb BMD were used as outcome variables. The survey weighted multivariable generalized additive models (GAMs) with smoothing terms were used to explore the association between blood lead levels and BMDs, adjusted for age, sex, race/ethnicity, height, weight, family-income-to-poverty ratio and blood cadmium. Subgroup analyses stratified by sex and bony sites were further performed. We found an N-shaped curve association between BLLs and total BMD, subtotal BMD and limb BMD for males and females, whereas the association between BLLs and lumbar spine BMD was only significantly negative for females. The findings suggested that lead exposure had different effects on BMD of different bony sites (highly cortical or trabecular regions) in childhood and adolescence and had different effects on the same bone among different ages population and/or at different levels. MDPI 2022-04-06 /pmc/articles/PMC9003082/ /pubmed/35406136 http://dx.doi.org/10.3390/nu14071523 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Li, Tao
Xie, Yixuan
Wang, Liang
Huang, Guimin
Cheng, Yijing
Hou, Dongqing
Liu, Wenqian
Zhang, Tong
Liu, Junting
The Association between Lead Exposure and Bone Mineral Density in Childhood and Adolescence: Results from NHANES 1999–2006 and 2011–2018
title The Association between Lead Exposure and Bone Mineral Density in Childhood and Adolescence: Results from NHANES 1999–2006 and 2011–2018
title_full The Association between Lead Exposure and Bone Mineral Density in Childhood and Adolescence: Results from NHANES 1999–2006 and 2011–2018
title_fullStr The Association between Lead Exposure and Bone Mineral Density in Childhood and Adolescence: Results from NHANES 1999–2006 and 2011–2018
title_full_unstemmed The Association between Lead Exposure and Bone Mineral Density in Childhood and Adolescence: Results from NHANES 1999–2006 and 2011–2018
title_short The Association between Lead Exposure and Bone Mineral Density in Childhood and Adolescence: Results from NHANES 1999–2006 and 2011–2018
title_sort association between lead exposure and bone mineral density in childhood and adolescence: results from nhanes 1999–2006 and 2011–2018
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9003082/
https://www.ncbi.nlm.nih.gov/pubmed/35406136
http://dx.doi.org/10.3390/nu14071523
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