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Amino Acid-Related Metabolic Signature in Obese Children and Adolescents

The growing interest in metabolomics has spread to the search for suitable predictive biomarkers for complications related to the emerging issue of pediatric obesity and its related cardiovascular risk and metabolic alteration. Indeed, several studies have investigated the association between metabo...

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Autores principales: Polidori, Nella, Grasso, Eleonora Agata, Chiarelli, Francesco, Giannini, Cosimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9003189/
https://www.ncbi.nlm.nih.gov/pubmed/35406066
http://dx.doi.org/10.3390/nu14071454
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author Polidori, Nella
Grasso, Eleonora Agata
Chiarelli, Francesco
Giannini, Cosimo
author_facet Polidori, Nella
Grasso, Eleonora Agata
Chiarelli, Francesco
Giannini, Cosimo
author_sort Polidori, Nella
collection PubMed
description The growing interest in metabolomics has spread to the search for suitable predictive biomarkers for complications related to the emerging issue of pediatric obesity and its related cardiovascular risk and metabolic alteration. Indeed, several studies have investigated the association between metabolic disorders and amino acids, in particular branched-chain amino acids (BCAAs). We have performed a revision of the literature to assess the role of BCAAs in children and adolescents’ metabolism, focusing on the molecular pathways involved. We searched on Pubmed/Medline, including articles published until February 2022. The results have shown that plasmatic levels of BCAAs are impaired already in obese children and adolescents. The relationship between BCAAs, obesity and the related metabolic disorders is explained on one side by the activation of the mTORC1 complex—that may promote insulin resistance—and on the other, by the accumulation of toxic metabolites, which may lead to mitochondrial dysfunction, stress kinase activation and damage of pancreatic cells. These compounds may help in the precocious identification of many complications of pediatric obesity. However, further studies are still needed to better assess if BCAAs may be used to screen these conditions and if any other metabolomic compound may be useful to achieve this goal.
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spelling pubmed-90031892022-04-13 Amino Acid-Related Metabolic Signature in Obese Children and Adolescents Polidori, Nella Grasso, Eleonora Agata Chiarelli, Francesco Giannini, Cosimo Nutrients Review The growing interest in metabolomics has spread to the search for suitable predictive biomarkers for complications related to the emerging issue of pediatric obesity and its related cardiovascular risk and metabolic alteration. Indeed, several studies have investigated the association between metabolic disorders and amino acids, in particular branched-chain amino acids (BCAAs). We have performed a revision of the literature to assess the role of BCAAs in children and adolescents’ metabolism, focusing on the molecular pathways involved. We searched on Pubmed/Medline, including articles published until February 2022. The results have shown that plasmatic levels of BCAAs are impaired already in obese children and adolescents. The relationship between BCAAs, obesity and the related metabolic disorders is explained on one side by the activation of the mTORC1 complex—that may promote insulin resistance—and on the other, by the accumulation of toxic metabolites, which may lead to mitochondrial dysfunction, stress kinase activation and damage of pancreatic cells. These compounds may help in the precocious identification of many complications of pediatric obesity. However, further studies are still needed to better assess if BCAAs may be used to screen these conditions and if any other metabolomic compound may be useful to achieve this goal. MDPI 2022-03-30 /pmc/articles/PMC9003189/ /pubmed/35406066 http://dx.doi.org/10.3390/nu14071454 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Polidori, Nella
Grasso, Eleonora Agata
Chiarelli, Francesco
Giannini, Cosimo
Amino Acid-Related Metabolic Signature in Obese Children and Adolescents
title Amino Acid-Related Metabolic Signature in Obese Children and Adolescents
title_full Amino Acid-Related Metabolic Signature in Obese Children and Adolescents
title_fullStr Amino Acid-Related Metabolic Signature in Obese Children and Adolescents
title_full_unstemmed Amino Acid-Related Metabolic Signature in Obese Children and Adolescents
title_short Amino Acid-Related Metabolic Signature in Obese Children and Adolescents
title_sort amino acid-related metabolic signature in obese children and adolescents
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9003189/
https://www.ncbi.nlm.nih.gov/pubmed/35406066
http://dx.doi.org/10.3390/nu14071454
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