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Amino Acid-Related Metabolic Signature in Obese Children and Adolescents
The growing interest in metabolomics has spread to the search for suitable predictive biomarkers for complications related to the emerging issue of pediatric obesity and its related cardiovascular risk and metabolic alteration. Indeed, several studies have investigated the association between metabo...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9003189/ https://www.ncbi.nlm.nih.gov/pubmed/35406066 http://dx.doi.org/10.3390/nu14071454 |
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author | Polidori, Nella Grasso, Eleonora Agata Chiarelli, Francesco Giannini, Cosimo |
author_facet | Polidori, Nella Grasso, Eleonora Agata Chiarelli, Francesco Giannini, Cosimo |
author_sort | Polidori, Nella |
collection | PubMed |
description | The growing interest in metabolomics has spread to the search for suitable predictive biomarkers for complications related to the emerging issue of pediatric obesity and its related cardiovascular risk and metabolic alteration. Indeed, several studies have investigated the association between metabolic disorders and amino acids, in particular branched-chain amino acids (BCAAs). We have performed a revision of the literature to assess the role of BCAAs in children and adolescents’ metabolism, focusing on the molecular pathways involved. We searched on Pubmed/Medline, including articles published until February 2022. The results have shown that plasmatic levels of BCAAs are impaired already in obese children and adolescents. The relationship between BCAAs, obesity and the related metabolic disorders is explained on one side by the activation of the mTORC1 complex—that may promote insulin resistance—and on the other, by the accumulation of toxic metabolites, which may lead to mitochondrial dysfunction, stress kinase activation and damage of pancreatic cells. These compounds may help in the precocious identification of many complications of pediatric obesity. However, further studies are still needed to better assess if BCAAs may be used to screen these conditions and if any other metabolomic compound may be useful to achieve this goal. |
format | Online Article Text |
id | pubmed-9003189 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-90031892022-04-13 Amino Acid-Related Metabolic Signature in Obese Children and Adolescents Polidori, Nella Grasso, Eleonora Agata Chiarelli, Francesco Giannini, Cosimo Nutrients Review The growing interest in metabolomics has spread to the search for suitable predictive biomarkers for complications related to the emerging issue of pediatric obesity and its related cardiovascular risk and metabolic alteration. Indeed, several studies have investigated the association between metabolic disorders and amino acids, in particular branched-chain amino acids (BCAAs). We have performed a revision of the literature to assess the role of BCAAs in children and adolescents’ metabolism, focusing on the molecular pathways involved. We searched on Pubmed/Medline, including articles published until February 2022. The results have shown that plasmatic levels of BCAAs are impaired already in obese children and adolescents. The relationship between BCAAs, obesity and the related metabolic disorders is explained on one side by the activation of the mTORC1 complex—that may promote insulin resistance—and on the other, by the accumulation of toxic metabolites, which may lead to mitochondrial dysfunction, stress kinase activation and damage of pancreatic cells. These compounds may help in the precocious identification of many complications of pediatric obesity. However, further studies are still needed to better assess if BCAAs may be used to screen these conditions and if any other metabolomic compound may be useful to achieve this goal. MDPI 2022-03-30 /pmc/articles/PMC9003189/ /pubmed/35406066 http://dx.doi.org/10.3390/nu14071454 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Polidori, Nella Grasso, Eleonora Agata Chiarelli, Francesco Giannini, Cosimo Amino Acid-Related Metabolic Signature in Obese Children and Adolescents |
title | Amino Acid-Related Metabolic Signature in Obese Children and Adolescents |
title_full | Amino Acid-Related Metabolic Signature in Obese Children and Adolescents |
title_fullStr | Amino Acid-Related Metabolic Signature in Obese Children and Adolescents |
title_full_unstemmed | Amino Acid-Related Metabolic Signature in Obese Children and Adolescents |
title_short | Amino Acid-Related Metabolic Signature in Obese Children and Adolescents |
title_sort | amino acid-related metabolic signature in obese children and adolescents |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9003189/ https://www.ncbi.nlm.nih.gov/pubmed/35406066 http://dx.doi.org/10.3390/nu14071454 |
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