Cargando…
Effects of Vitamin D Supplementation on 24-Hour Blood Pressure in Patients with Low 25-Hydroxyvitamin D Levels: A Randomized Controlled Trial
Accumulating evidence suggests that potential cardiovascular benefits of vitamin D supplementation may be restricted to individuals with very low 25-hydroxyvitamin D (25(OH)D) concentrations; the effect of vitamin D on blood pressure (BP) remains unclear. We addressed this issue in a post hoc analys...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9003372/ https://www.ncbi.nlm.nih.gov/pubmed/35405973 http://dx.doi.org/10.3390/nu14071360 |
_version_ | 1784686118940180480 |
---|---|
author | Theiler-Schwetz, Verena Trummer, Christian Grübler, Martin R. Keppel, Martin H. Zittermann, Armin Tomaschitz, Andreas Karras, Spyridon N. März, Winfried Pilz, Stefan Gängler, Stephanie |
author_facet | Theiler-Schwetz, Verena Trummer, Christian Grübler, Martin R. Keppel, Martin H. Zittermann, Armin Tomaschitz, Andreas Karras, Spyridon N. März, Winfried Pilz, Stefan Gängler, Stephanie |
author_sort | Theiler-Schwetz, Verena |
collection | PubMed |
description | Accumulating evidence suggests that potential cardiovascular benefits of vitamin D supplementation may be restricted to individuals with very low 25-hydroxyvitamin D (25(OH)D) concentrations; the effect of vitamin D on blood pressure (BP) remains unclear. We addressed this issue in a post hoc analysis of the double-blind, randomized, placebo-controlled Styrian Vitamin D Hypertension Trial (2011–2014) with 200 hypertensive patients with 25(OH)D levels <30 ng/mL. We evaluated whether 2800 IU of vitamin D3/day or placebo (1:1) for 8 weeks affects 24-hour systolic ambulatory BP in patients with 25(OH)D concentrations <20 ng/mL, <16 ng/mL, and <12 ng/mL and whether achieved 25(OH)D concentrations were associated with BP measures. Taking into account correction for multiple testing, p values < 0.0026 were considered significant. No significant treatment effects on 24-hour BP were observed when different baseline 25(OH)D thresholds were used (all p-values > 0.30). However, there was a marginally significant trend towards an inverse association between the achieved 25(OH)D level with 24-hour systolic BP (−0.196 per ng/mL 25(OH)D, 95% CI (−0.325 to −0.067); p = 0.003). In conclusion, we could not document the antihypertensive effects of vitamin D in vitamin D-deficient individuals, but the association between achieved 25(OH)D concentrations and BP warrants further investigations on cardiovascular benefits of vitamin D in severe vitamin D deficiency. |
format | Online Article Text |
id | pubmed-9003372 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-90033722022-04-13 Effects of Vitamin D Supplementation on 24-Hour Blood Pressure in Patients with Low 25-Hydroxyvitamin D Levels: A Randomized Controlled Trial Theiler-Schwetz, Verena Trummer, Christian Grübler, Martin R. Keppel, Martin H. Zittermann, Armin Tomaschitz, Andreas Karras, Spyridon N. März, Winfried Pilz, Stefan Gängler, Stephanie Nutrients Article Accumulating evidence suggests that potential cardiovascular benefits of vitamin D supplementation may be restricted to individuals with very low 25-hydroxyvitamin D (25(OH)D) concentrations; the effect of vitamin D on blood pressure (BP) remains unclear. We addressed this issue in a post hoc analysis of the double-blind, randomized, placebo-controlled Styrian Vitamin D Hypertension Trial (2011–2014) with 200 hypertensive patients with 25(OH)D levels <30 ng/mL. We evaluated whether 2800 IU of vitamin D3/day or placebo (1:1) for 8 weeks affects 24-hour systolic ambulatory BP in patients with 25(OH)D concentrations <20 ng/mL, <16 ng/mL, and <12 ng/mL and whether achieved 25(OH)D concentrations were associated with BP measures. Taking into account correction for multiple testing, p values < 0.0026 were considered significant. No significant treatment effects on 24-hour BP were observed when different baseline 25(OH)D thresholds were used (all p-values > 0.30). However, there was a marginally significant trend towards an inverse association between the achieved 25(OH)D level with 24-hour systolic BP (−0.196 per ng/mL 25(OH)D, 95% CI (−0.325 to −0.067); p = 0.003). In conclusion, we could not document the antihypertensive effects of vitamin D in vitamin D-deficient individuals, but the association between achieved 25(OH)D concentrations and BP warrants further investigations on cardiovascular benefits of vitamin D in severe vitamin D deficiency. MDPI 2022-03-24 /pmc/articles/PMC9003372/ /pubmed/35405973 http://dx.doi.org/10.3390/nu14071360 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Theiler-Schwetz, Verena Trummer, Christian Grübler, Martin R. Keppel, Martin H. Zittermann, Armin Tomaschitz, Andreas Karras, Spyridon N. März, Winfried Pilz, Stefan Gängler, Stephanie Effects of Vitamin D Supplementation on 24-Hour Blood Pressure in Patients with Low 25-Hydroxyvitamin D Levels: A Randomized Controlled Trial |
title | Effects of Vitamin D Supplementation on 24-Hour Blood Pressure in Patients with Low 25-Hydroxyvitamin D Levels: A Randomized Controlled Trial |
title_full | Effects of Vitamin D Supplementation on 24-Hour Blood Pressure in Patients with Low 25-Hydroxyvitamin D Levels: A Randomized Controlled Trial |
title_fullStr | Effects of Vitamin D Supplementation on 24-Hour Blood Pressure in Patients with Low 25-Hydroxyvitamin D Levels: A Randomized Controlled Trial |
title_full_unstemmed | Effects of Vitamin D Supplementation on 24-Hour Blood Pressure in Patients with Low 25-Hydroxyvitamin D Levels: A Randomized Controlled Trial |
title_short | Effects of Vitamin D Supplementation on 24-Hour Blood Pressure in Patients with Low 25-Hydroxyvitamin D Levels: A Randomized Controlled Trial |
title_sort | effects of vitamin d supplementation on 24-hour blood pressure in patients with low 25-hydroxyvitamin d levels: a randomized controlled trial |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9003372/ https://www.ncbi.nlm.nih.gov/pubmed/35405973 http://dx.doi.org/10.3390/nu14071360 |
work_keys_str_mv | AT theilerschwetzverena effectsofvitamindsupplementationon24hourbloodpressureinpatientswithlow25hydroxyvitamindlevelsarandomizedcontrolledtrial AT trummerchristian effectsofvitamindsupplementationon24hourbloodpressureinpatientswithlow25hydroxyvitamindlevelsarandomizedcontrolledtrial AT grublermartinr effectsofvitamindsupplementationon24hourbloodpressureinpatientswithlow25hydroxyvitamindlevelsarandomizedcontrolledtrial AT keppelmartinh effectsofvitamindsupplementationon24hourbloodpressureinpatientswithlow25hydroxyvitamindlevelsarandomizedcontrolledtrial AT zittermannarmin effectsofvitamindsupplementationon24hourbloodpressureinpatientswithlow25hydroxyvitamindlevelsarandomizedcontrolledtrial AT tomaschitzandreas effectsofvitamindsupplementationon24hourbloodpressureinpatientswithlow25hydroxyvitamindlevelsarandomizedcontrolledtrial AT karrasspyridonn effectsofvitamindsupplementationon24hourbloodpressureinpatientswithlow25hydroxyvitamindlevelsarandomizedcontrolledtrial AT marzwinfried effectsofvitamindsupplementationon24hourbloodpressureinpatientswithlow25hydroxyvitamindlevelsarandomizedcontrolledtrial AT pilzstefan effectsofvitamindsupplementationon24hourbloodpressureinpatientswithlow25hydroxyvitamindlevelsarandomizedcontrolledtrial AT ganglerstephanie effectsofvitamindsupplementationon24hourbloodpressureinpatientswithlow25hydroxyvitamindlevelsarandomizedcontrolledtrial |