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New composition of tungsten has a broad range of antiviral activity
The water-based combination of two inorganic chemical compounds such as sodium tungstate dihydrate-Na(2)WO(4) × 2H(2)O and Aluminum sulfate octadecahydrate-Al(2) (SO(4)) 3 × 18H(2)O that we have conditionally named ‘Vomifal’ has a broad antiviral activity in various DNA and RNA viruses, including Hu...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9003664/ https://www.ncbi.nlm.nih.gov/pubmed/35392696 http://dx.doi.org/10.1177/20402066221090061 |
Sumario: | The water-based combination of two inorganic chemical compounds such as sodium tungstate dihydrate-Na(2)WO(4) × 2H(2)O and Aluminum sulfate octadecahydrate-Al(2) (SO(4)) 3 × 18H(2)O that we have conditionally named ‘Vomifal’ has a broad antiviral activity in various DNA and RNA viruses, including Human Herpes Virus (HHV), African Swine Fever Virus (ASFV), Vaccinia Virus (VV), Hepatitis C Virus (HCV), Foot and Mouth Disease Virus (FMDV), Influenza A virus (A/Aichi/2/68 (H3N2)). In vitro and In vivo assays in several tissue cultures as well as in laboratory animals, conformed ‘Vomifal’ has a very low toxicity and the antiviral properties partially are due to its ability to induce gamma-IFN. Based on the results obtained, we can assume the presence of at least two mechanisms of the antiviral action of the studied drug. First or early stage - an unknown mechanism, possibly related to the effect on cellular receptors. Second or late stage – main antiviral properties probably associated with an interferonogenic effect. |
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